Protein Alignment ATP8A and ALA2

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_568633.2
• Gene: ALA2 / 834447
• AraportID: AT5G44240
• Length: 1139
• Species: Arabidopsis thaliana
• Alignment Length: 1113
• Identity: 399/1113 - (35%)
• Similarity: 624/1113 - (56%)
• Gaps: 106/1113 - (9%)

  Fly   217 RIINLNGPQPTK--YGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRY 279
            |.:.:|..:.:|  ..:|||:..||:..:|||..|:|||.|:.|.:|||||.||....::|....
plant    35 RFVYINDDEASKELCCDNRISNRKYTLWNFLPKNLWEQFSRFMNQYFLLIACLQLWSLITPVNPA 99

  Fly   280 TTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTF 344
            :|..||:||.:|||.||..:|..|:.:|.:.|.:.:..:..|....::..::.||:|:.:..|..
plant   100 STWGPLIFIFAVSASKEAWDDYHRYLSDKKANEKEVWIVKQGIKKHIQAQDIQVGNIVWLRENDE 164

  Fly   345 FPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLY 409
            .|.||:||.:|:||.:|::|||.|||||:||.| .:|:....::.:.|.:::|.|||.:|::.:.
plant   165 VPCDLVLLGTSDPQGVCYVETAALDGETDLKTR-VIPSACVGIDLELLHKMKGVIECPVPDKDIR 228

  Fly   410 EFNGVLRETGKPPAALGND-------QVLQRGAILRNTAWVFGIVVYSGQETKL-MKNSTSAP-- 464
            .|:..:|..   |..:.||       ..|.:...||||.|..|:.||:|.:||| |....:.|
plant   229 RFDANMRLF---PPFIDNDVCSLTIKNTLLQSCYLRNTEWACGVSVYTGNQTKLGMSRGIAEPKL 290

  Fly   465 -LKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGYNLLT-- 526
             ...:.:||||..    :|:..|.:.::.|:....|....:...||:   .:..::..|.||.
plant   291 TAMDAMIDKLTGA----IFVFQIVVVLVLGIAGNVWKDTEARKQWYV---QYPEEAPWYELLVIP 348

  Fly   527 --FFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSD 589
              |.:|.:.:||||::|:|:||:.|.|.||.:|:||..:|:.|.:.|..:.::|:||.|:||.:|
plant   349 LRFELLCSIMIPISIKVSLDLVKGLYAKFIEWDVEMIDQETGTASYAANTAISEDLGQVEYILTD 413

  Fly   590 KTGTLTQNVMEFKKCSIAGYVYTAER--TPEESQLVQNILGRHETSAVIEEFLELLSVCHTVIPE 652
            ||||||.|.|.|::|.|.|..|..|.  ..:::||: |.:....|..:  .||.::::|:||:|.
plant   414 KTGTLTDNKMIFRRCCIGGIFYGNENGDALKDAQLL-NAITSGSTDVI--RFLTVMAICNTVLPV 475

  Fly   653 RKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMS 717
            :.:.|:::|.|.|.||.|||..|.|...:|..:....:||...|...|||||.:|||||.|||||
plant   476 QSKAGDIVYKAQSQDEDALVIAASKLHMVFVGKNANLLEIRFNGSVIRYEVLEILEFTSDRKRMS 540

  Fly   718 LIVRTPEN-KIKLFCKGADTVI--YERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDV 779
            ::|:..:| ||.|..||||..|  |.|...|.:...:.    :|.::..||||||||..::..:.
plant   541 VVVKDCQNGKIILLSKGADEAILPYARAGQQTRTIGDA----VEHYSQLGLRTLCLAWRELEENE 601

  Fly   780 YQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWV 844
            |.|||..|.:||..|.:||.::.:....:|::|.:||.|||||||||||||||.:|..|||..|:
plant   602 YLEWSVKFKEASSLLVDREWRIAEVCQRLEHDLYILGVTAIEDRLQDGVPETIETLRKAGINFWM 666

  Fly   845 LTGDKQETAINIGYSCRLISHSM--DIIILNEESLDATREVIHRHYGEFKSSSAKDANVALVIDG 907
            ||||||.|||.|..||..||...  .:::::.::.:.....:.|.....:.::::..:||.||||
plant   667 LTGDKQNTAIQIALSCNFISPEPKGQLLMIDGKTEEDVSRSLERVLLTMRITASEPKDVAFVIDG 731

  Fly   908 TTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQK 972
            ..|:.||. ..|.||.:|.||.|..|||||:|.|||::|| :.:|.:..|||||||.|||.|||:
plant   732 WALEIALK-HHRKDFVELAILSRTAICCRVTPSQKAQLVE-ILKSCDYRTLAIGDGGNDVRMIQQ 794

  Fly   973 ANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWF 1037
            |::|:||||.||||||.|:||||.:||:|:||:||||.::|.|.:.|..|||||::.:..|:::|
plant   795 ADIGVGISGREGLQAARAADYSIGRFRFLKRLILVHGRYSYNRTAFLSQYSFYKSLLICFIQIFF 859

  Fly  1038 AVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVF 1102
            :..||.||..||...::..|||.:|:: |..:.:.:|..:..:::::|.:....|..:|.|...|
plant   860 SFISGVSGTSLFNSVSLMAYNVFYTSV-PVLVSVIDKDLSEASVMQHPQILFYCQAGRLLNPSTF 923

  Fly  1103 WIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVC--LKAGLI---TN 1162
            ..|...:|.|::.:|.:.:.||..|       .|:...:|     .|.::.|  |:|.::   ||
plant   924 AGWFGRSLFHAIIVFVITIHAYAYE-------KSEMEELG-----MVALSGCIWLQAFVVAQETN 976

  Fly  1163 SWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLV------PI 1221
            |:|.|.||:|||::|.::....::|.:.....:...||     |.|.|.::..:.|:      ||
plant   977 SFTVLQHLSIWGNLVGFYAINFLFSAIPSSGMYTIMFR-----LCSQPSYWITMFLIVGAGMGPI 1036

  Fly  1222 TTLLIDVICKLVHNTV----FKTLTEAVR-----------ETEIR--RSDISEV----------M 1259
            ..|      |....|.    ...|.:|.|           ||:.|  ..|:|.:          :
plant  1037 FAL------KYFRYTYRPSKINILQQAERMGGPILTLGNIETQPRTIEKDLSPISITQPKNRSPV 1095

  Fly  1260 NEPRSSDS 1267
            .||..|||
plant  1096 YEPLLSDS 1103

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	351/910 (39%)
ALA2	NP_568633.2	P-type_ATPase_APLT	51..939	CDD:319838	350/908 (39%)
		Cation_ATPase	467..565	CDD:463817	44/97 (45%)