DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and AT3G25610

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_189189.1	Gene:	AT3G25610 / 822148	AraportID:	AT3G25610	Length:	1202	Species:	Arabidopsis thaliana

Alignment Length:	1221	Identity:	479/1221 - (39%)
Similarity:	687/1221 - (56%)	Gaps:	166/1221 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 SRRRSSNRKDSKGSILSRQSGKSRVSLLAQRGLRMTASFLRRKRTEYEDDEDFTSSAGYDADDGE 215
            ||||   |:.....|.|...|||              ||          .||.::..|    .|.
plant     5 SRRR---RRLHLSKIYSYTCGKS--------------SF----------QEDHSNIGG----PGF 38

  Fly   216 RRIINLNGP-----QPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSP 275
            .|::..|.|     :...|..|.:.:.||:..||.|..|||||||.:|.:||:..|| .:.::||
plant    39 SRVVYCNEPGSPAAERRNYAGNYVRSTKYTVASFFPKSLFEQFRRVANFYFLVTGIL-SLTDLSP 102

  Fly   276 TGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLD-SGSWCTVRWSELTVGDIIKV 339
            .|..:.|:||..::|.:.:||.|||.:|.:.|.|:|:|.::..| :|.:....|..|.||||::|
plant   103 YGAVSALLPLALVISATMVKEGIEDWRRKQQDIEVNNRKVKVHDGNGIFRQEEWRNLRVGDIVRV 167

  Fly   340 GINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELL-ETKDLQRLEGRIECEL 403
            ..:.||||||:|||||...::|::||.|||||||||::|.|.||:.|| :..|.:...|.:.||.
plant   168 EKDEFFPADLLLLSSSYEDSVCYVETMNLDGETNLKVKQGLEATSSLLNQDSDFKDFRGVVRCED 232

  Fly   404 PNRHLYEFNGVLR-ETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKR 467
            ||.:||.|.|.|. |..:.|.::  .|:|.|.:.||||.:|:|.||::|.:||:::|||..|.||
plant   233 PNVNLYVFVGTLALEEERFPLSI--QQILLRDSKLRNTEYVYGAVVFTGHDTKVIQNSTDPPSKR 295

  Fly   468 STVDKLTNTQILMLFMILISLCIISGLCNLFWTRE----HSETD-WYLGLTD----FKTK----S 519
            |.:::..:..|.::|.::..:..:..:.....|||    :..|: |||...|    |..:    :
plant   296 SRIERTMDKIIYLMFGLVFLMSFVGSIIFGVETREDKVKNGRTERWYLKPDDADIFFDPERAPMA 360

  Fly   520 LGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVK 584
            ..|:..|..:||:..|||||.|::|:|:.||:||||.||.||:||::.||.|||||||||||||.
plant   361 AIYHFFTATMLYSYFIPISLYVSIEIVKVLQSIFINRDIHMYYEETDKPAQARTSNLNEELGMVD 425

  Fly   585 YIFSDKTGTLTQNVMEFKKCSIAGYVYTAERTPEE---------SQLVQNILG------------ 628
            .|.||||||||.|.|||.||||||..|....|..|         |.||...|.
plant   426 TILSDKTGTLTCNSMEFIKCSIAGKAYGRGITEVERAMAVRSGGSPLVNEDLDVVVDQSGPKVKG 490

  Fly   629 --------------RHETSAVIEEFLELLSVCHTVIPER-KENGNMIYHAASPDERALVEGAQKF 678
                          |...:||:::|..||:||||.|||. :|:||:.|.|.||||.|.|..|::|
plant   491 FNFEDERVMNGNWVRQPEAAVLQKFFRLLAVCHTAIPETDEESGNVSYEAESPDEAAFVVAAREF 555

  Fly   679 GYIFDTRTPKYVEINALG------VRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTV 737
            |:.|..||...:....|.      |.:.|.:||||||.|:|||||:|||..:.|:.|..||||.|
plant   556 GFEFFNRTQNGISFRELDLVSGEKVERVYRLLNVLEFNSTRKRMSVIVRDDDGKLLLLSKGADNV 620

  Fly   738 IYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFD--KASVALQNRESK 800
            ::||||..|:.|..:|..|:.::|..|||||.||..::..:.|.|::::|:  ||||: ::||:.
plant   621 MFERLAKNGRQFEAKTQEHVNQYADAGLRTLVLAYREVDENEYIEFNKSFNEAKASVS-EDREAL 684

  Fly   801 LEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISH 865
            :::..:.:|.:|.||||||:||:||:||||.|..|..|||.||||||||.|||||||::..|:..
plant   685 IDEITDKMERDLILLGATAVEDKLQNGVPECIDKLAQAGIKIWVLTGDKMETAINIGFASSLLRQ 749

  Fly   866 SMDIIILNEE-----SLD----------ATREVIHRHYGEFK----SSSAKDANVALVIDGTTLK 911
            .|..||:|.|     ||:          |:||.:.....|.|    :|.|.....||:|||.:|.
plant   750 EMKQIIINLETPQIKSLEKSGGKDEIELASRESVVMQLQEGKALLAASGASSEAFALIIDGKSLT 814

  Fly   912 YALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVG 976
            |||..:::..|.||...|..|||||.||.|||.|..:|...|...|||||||||||.|:|:|::|
plant   815 YALEDEIKKMFLDLATSCASVICCRSSPKQKALVTRLVKSGTGKTTLAIGDGANDVGMLQEADIG 879

  Fly   977 IGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYS 1041
            :|||||||:||..:||.:|||||||:|||||||.|.|:||:.:|.|.||||:...|....:..|:
plant   880 VGISGVEGMQAVMSSDIAIAQFRYLERLLLVHGHWCYSRIASMICYFFYKNITFGVTVFLYEAYT 944

  Fly  1042 GWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWI 1106
            .:|||..:..|.:.|:||.|:::|..|:|:|::..:|....::|:||:......||:.|....|:
plant   945 SFSGQPAYNDWFLSLFNVFFSSLPVIALGVFDQDVSARFCYKFPLLYQEGVQNILFSWKRIIGWM 1009

  Fly  1107 FNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLA 1171
            ||..:.::.:|:|...:...::...||||:...::|..:||.|:..|.|:..|..:.:||:.|:.
plant  1010 FNGFISALAIFFLCKESLKHQLFDPDGKTAGREILGGTMYTCVVWVVNLQMALSISYFTWVQHIV 1074

  Fly  1172 IWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLSTPVF-YFCLMLVP-----ITTLLIDVIC 1230
            |||||..|:.||:||..:.|.|              ||..: .|...|.|     :|||.: :|.
plant  1075 IWGSIAFWYIFLMIYGAMTPSF--------------STDAYMVFLEALAPAPSYWLTTLFV-MIF 1124

  Fly  1231 KLVHNTVFKTL--------------------------TEAVRETEIRRSDI 1255
            .|:...|:|::                          .|.||:..||.:.:
plant  1125 ALIPYFVYKSVQMRFFPKYHQMIQWIRYEGHSNDPEFVEMVRQRSIRPTTV 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	24/66 (36%)
		ATPase-Plipid	229..1247	CDD:273734	457/1128 (41%)
		E1-E2_ATPase	286..>371	CDD:278548	37/85 (44%)
		Cation_ATPase	645..741	CDD:289987	49/102 (48%)
		HAD_like	<942..1001	CDD:304363	36/58 (62%)
		PhoLip_ATPase_C	988..1240	CDD:292829	89/257 (35%)
AT3G25610	NP_189189.1	PhoLip_ATPase_N	41..107	CDD:292826	24/66 (36%)
		ATPase-Plipid	57..1148	CDD:273734	455/1109 (41%)
		Cation_ATPase	521..624	CDD:289987	49/102 (48%)
		COG4087	<840..898	CDD:226572	34/57 (60%)
		PhoLip_ATPase_C	891..1141	CDD:292829	90/264 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	281	1.000	Domainoid score	I393
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	827	1.000	Inparanoid score	I77
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm2889
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840