DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8A and ATP8B4

DIOPT Version :9

Sequence 1:NP_001137651.1 Gene:ATP8A / 36488 FlyBaseID:FBgn0259221 Length:1350 Species:Drosophila melanogaster
Sequence 2:XP_011520348.1 Gene:ATP8B4 / 79895 HGNCID:13536 Length:1257 Species:Homo sapiens


Alignment Length:1232 Identity:477/1232 - (38%)
Similarity:718/1232 - (58%) Gaps:148/1232 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 SAGYDADDGER----------------RIINLNG---PQPTKYGNNRITTAKYSFISFLPAFLFE 251
            |.|:....|||                ||:..|.   .:..:|.:|||.|:||:.::|||..|||
Human    23 SVGHLLRPGERSGIIMFCSEKKLREVERIVKANDREYNEKFQYADNRIHTSKYNILTFLPINLFE 87

  Fly   252 QFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIE 316
            ||:|.:|.:||.:.|||.|||:|....:||:|||:.:::::|:|:..:|..||::||::|:|..|
Human    88 QFQRVANAYFLCLLILQLIPEISSLTWFTTIVPLVLVITMTAVKDATDDYFRHKSDNQVNNRQSE 152

  Fly   317 RLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDG----------- 370
            .|.:......:|..:.||||||:..|.|..|||:|||||||..:|::|||.|||           
Human   153 VLINSKLQNEKWMNVKVGDIIKLENNQFVAADLLLLSSSEPHGLCYVETAELDGSLCCYKDVPWV 217

  Fly   371 -----------------ETNLKIRQALPATAELLETKDLQRL---EGRIECELPNRHLYEFNGVL 415
                             |||||:|.||..|:||  ..|:.||   :|.:.||:||..|.:|.|:|
Human   218 ECQLFGAQEALPTFLKQETNLKVRHALSVTSEL--GADISRLAGFDGIVVCEVPNNKLDKFMGIL 280

  Fly   416 R-ETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQIL 479
            . :..|  .:|.|::::.||.|||||:|.||:|:::|.:||||:||.....||:::|:|.||.:|
Human   281 SWKDSK--HSLNNEKIILRGCILRNTSWCFGMVIFAGPDTKLMQNSGKTKFKRTSIDRLMNTLVL 343

  Fly   480 MLFMILISLCIISGLCNLFW---TREHSETDWYLGLTDFKTKSLGYNLLTFF---ILYNNLIPIS 538
            .:|..||.|.||..:.|..|   |.:...|  :|...:.:..|:....|||:   |:.|.::|||
Human   344 WIFGFLICLGIILAIGNSIWESQTGDQFRT--FLFWNEGEKSSVFSGFLTFWSYIIILNTVVPIS 406

  Fly   539 LQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKK 603
            |.|::|::|...:.|||:|.:||:.....||:|||:.||||||.::|||||||||||||:|.||:
Human   407 LYVSVEVIRLGHSYFINWDRKMYYSRKAIPAVARTTTLNEELGQIEYIFSDKTGTLTQNIMTFKR 471

  Fly   604 CSIAGYVY-------------TAERTPEESQLVQ------NILGRHETSAV------IEEFLELL 643
            |||.|.:|             |.|:.|.:..:..      .....|...::      :.|||.||
Human   472 CSINGRIYGEVHDDLDQKTEITQEKEPVDFSVKSQADREFQFFDHHLMESIKMGDPKVHEFLRLL 536

  Fly   644 SVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLE 708
            ::||||:.|....|.:||...||||.|||..|:.||:||.:|||:.:.|..||....|::|..|:
Human   537 ALCHTVMSEENSAGELIYQVQSPDEGALVTAARNFGFIFKSRTPETITIEELGTLVTYQLLAFLD 601

  Fly   709 FTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVA 773
            |.::|||||:|||.||.:|||:.|||||:::|:|.|..:.....|..||.|||.:|||||.:|..
Human   602 FNNTRKRMSVIVRNPEGQIKLYSKGADTILFEKLHPSNEVLLSLTSDHLSEFAGEGLRTLAIAYR 666

  Fly   774 DIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDA 838
            |:....::||.:..:.|:.|.:.|:.::......||.:|.||||||:||:||:||.||:.||..|
Human   667 DLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGATAVEDKLQEGVIETVTSLSLA 731

  Fly   839 GIYIWVLTGDKQETAINIGYSCRLISHSM-DIIILNEESLDATREVI----------HRHYG--- 889
            .|.|||||||||||||||||:|.:::..| |:.::...:....||.:          :|::.   
Human   732 NIKIWVLTGDKQETAINIGYACNMLTDDMNDVFVIAGNNAVEVREELRKAKQNLFGQNRNFSNGH 796

  Fly   890 ---EFKSSSAKDANV--------ALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKA 943
               |.|.....|:.|        ||:|:|.:|.:||..|::||..:|..:|:.||||||:|:|||
Human   797 VVCEKKQQLELDSIVEETITGDYALIINGHSLAHALESDVKNDLLELACMCKTVICCRVTPLQKA 861

  Fly   944 EVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVH 1008
            :|||:|.:..||||||||||||||:||:.|::|:||||.|||||..|||||.|||||||||||||
Human   862 QVVELVKKYRNAVTLAIGDGANDVSMIKSAHIGVGISGQEGLQAVLASDYSFAQFRYLQRLLLVH 926

  Fly  1009 GAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFE 1073
            |.|:|.|:.|.:.|.||||....::..||..:.|:|.|.::::|.|.|:|:::|::|..|||:|:
Human   927 GRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLFNIVYTSLPVLAMGIFD 991

  Fly  1074 KFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGK-TSD 1137
            :..:.:..:..|.|||..|...|||.:.|:|.:.:.:..|:.||::|..|: ..|...||: .:|
Human   992 QDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTSLVLFFIPYGAF-YNVAGEDGQHIAD 1055

  Fly  1138 YLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLL-IYSH----VWP-MFKFA 1196
            |......:.|.:::.|.::..|.|:.||::.|:.|||||.::|..|. ::|:    ::| .|.|.
Human  1056 YQSFAVTMATSLVIVVSVQIALDTSYWTFINHVFIWGSIAIYFSILFTMHSNGIFGIFPNQFPFV 1120

  Fly  1197 SNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNE 1261
            .|.|    ..|:....:..::|..:.:::..|..:.:...::.||::     :|||...::....
Human  1121 GNAR----HSLTQKCIWLVILLTTVASVMPVVAFRFLKVDLYPTLSD-----QIRRWQKAQKKAR 1176

  Fly  1262 P---------RSSDSGFGYAL------GKLIRSSHILISHDHHPVSESSRT---SNLRVENL 1305
            |         |||....|||.      |:||.|...:.:.:..|.|...:|   |...:|||
Human  1177 PPSSRRPRTRRSSSRRSGYAFAHQEGYGELITSGKNMRAKNPPPTSGLEKTHYNSTSWIENL 1238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8ANP_001137651.1 PhoLip_ATPase_N 218..280 CDD:292826 28/64 (44%)
ATPase-Plipid 229..1247 CDD:273734 448/1112 (40%)
E1-E2_ATPase 286..>371 CDD:278548 37/112 (33%)
Cation_ATPase 645..741 CDD:289987 48/95 (51%)
HAD_like <942..1001 CDD:304363 42/58 (72%)
PhoLip_ATPase_C 988..1240 CDD:292829 86/258 (33%)
ATP8B4XP_011520348.1 PhoLip_ATPase_N 51..116 CDD:292826 28/64 (44%)
ATPase-Plipid 65..1167 CDD:273734 449/1117 (40%)
Cation_ATPase 538..634 CDD:289987 48/95 (51%)
HAD_like <875..906 CDD:304363 23/30 (77%)
PhoLip_ATPase_C 906..1160 CDD:292829 86/258 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X168
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.730

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