Protein Alignment ATP8A and atp8a1

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_073778311.1
• Gene: atp8a1 / 767630
• ZFINID: ZDB-GENE-060929-36
• Length: 1173
• Species: Danio rerio
• Alignment Length: 1141
• Identity: 618/1141 - (54%)
• Similarity: 818/1141 - (71%)
• Gaps: 20/1141 - (1%)

  Fly   183 LRMTASFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPA 247
            ::.|.|.||.:...||..|| ||.....||..:.|:|.::.||.||:.:||::||||:.::|||.
Zfish     4 VQRTMSDLRTRADGYEKTED-TSEKTSLADQEDSRLIFISQPQFTKFCSNRVSTAKYNVLTFLPR 67

  Fly   248 FLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINH 312
            ||:.||||.:|.|||.||:|||||:||||||:||||||:|||.|:|:||||||:|||.|||.:|.
Zfish    68 FLYSQFRRAANSFFLFIALLQQIPDVSPTGRWTTLVPLLFILVVAAVKEIIEDLKRHNADNVVNK 132

  Fly   313 RSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIR 377
            :..:.|.:|:|..|.|.:::||:|::.......|||||:|||||||.||:|||:|||||||||||
Zfish   133 KETQVLRNGAWEIVHWEKVSVGEIVRAANGDHLPADLIILSSSEPQGMCYIETSNLDGETNLKIR 197

  Fly   378 QALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAW 442
            |.|..|.::.:...|.||.||:|||.||||||||.|.:|..|.....||.||:|.|||.||||.|
Zfish   198 QGLTITTDIKDIDGLMRLSGRMECESPNRHLYEFVGNIRLDGHGTVPLGPDQILLRGAQLRNTQW 262

  Fly   443 VFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETD 507
            |.|||||:|.:||||:|||..|||.|.|:::||.|||:||..|:::.::..:....|..:.....
Zfish   263 VHGIVVYTGHDTKLMQNSTRPPLKLSNVERITNFQILVLFGCLLAISLVCSIGQTIWKYQFGNDA 327

  Fly   508 WYLGLTDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMAR 572
            ||:.|......:.|.|.|||.||:||||||||.||||:::|:||.|||:|.:|.:|.:|||||||
Zfish   328 WYMDLNYGGAANFGLNFLTFIILFNNLIPISLLVTLEVIKFVQAFFINWDTDMLYEATNTPAMAR 392

  Fly   573 TSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAG--YVYTAERTPE----ESQLVQNILGRHE 631
            |||||||||.|||||||||||||.|||:||||:|||  |.::::.|.|    :..|::|:...|.
Zfish   393 TSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHSSQSTEETGFNDPSLLENLQSNHP 457

  Fly   632 TSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALG 696
            |:.||.||:.::::|||.:|||.:| .:.|.||||||.|||..||..|::|..|||..|.:.:|.
Zfish   458 TAPVIMEFMTMMAICHTAVPERTDN-RITYQAASPDEGALVRAAQNLGFVFSGRTPDSVIVESLE 521

  Fly   697 VRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFA 761
            ..::||:|:||||||:|||||:|:|||..||:|:|||||||||||||...: :::.||:|||:||
Zfish   522 AEEKYELLHVLEFTSTRKRMSVIMRTPAGKIRLYCKGADTVIYERLADSSR-YKDITLKHLEQFA 585

  Fly   762 SDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQD 826
            ::||||||.|||||....||:|.:.:.:||.:||||..|:|::..|||.||:|||||||||:|||
Zfish   586 TEGLRTLCFAVADISESSYQQWLEVYHRASTSLQNRALKMEESYELIEKNLQLLGATAIEDKLQD 650

  Fly   827 GVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHRHYGEF 891
            .|||||.:|:.|.|.||:|||||||||||||:||:|::.:|.::::||::||.|||.:..|.|..
Zfish   651 KVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLTKNMGLLVINEDTLDGTRETLSHHCGML 715

  Fly   892 KSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAV 956
            ..:..|:.:.||:|||.||||||:...|..|.||.:.|:.||||||||:||:||||||.:....:
Zfish   716 GDALHKENDFALIIDGKTLKYALTFGARQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVI 780

  Fly   957 TLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLIL 1021
            |||||||||||.|||.|:||:||||.||||||.:||||||||:||:.||||||||||.|::|.||
Zfish   781 TLAIGDGANDVGMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLLVHGAWNYNRVAKCIL 845

  Fly  1022 YSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPM 1086
            |.||||:.||:||:|||..:|:|||||||||.||||||:|||:||..:|:||:.|..|.|::||.
Zfish   846 YCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVIFTALPPLTLGIFERSCRKENMLKYPE 910

  Fly  1087 LYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIV 1151
            ||||||||..||.||||....|.|.|||.|||.||.|:..:.::.:|||.||||:||:|||:|::
Zfish   911 LYKTSQNAMGFNTKVFWAHCLNGLFHSVILFWFPLKAFQHDTVFGNGKTPDYLLLGNMVYTFVVI 975

  Fly  1152 TVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYFCL 1216
            ||||||||.|:|||..:|:||||||.||..|..|||.:||:...|.:..|....:.|:.||:..|
Zfish   976 TVCLKAGLETSSWTMFSHIAIWGSIGLWVVFFGIYSSLWPLIPLAPDMSGEADMMFSSGVFWMGL 1040

  Fly  1217 MLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRSSDSG------FGYALGK 1275
            :.:|||:|:.||..|::....||||.:.|:|.|....|...|::....::..      |..:...
Zfish  1041 IFIPITSLVFDVAYKVMKKVCFKTLVDEVQELEALSKDPGAVVHGKSLTERAQLLKNVFKKSTVS 1105

  Fly  1276 LIRSSHILISHDHHPVSESSRTSNLRVENLEMEADT 1311
            |.||..:     ...:..:|.|....|.:...:|||
Zfish  1106 LYRSDSM-----QQNLLRTSATHMCSVSHRHTDADT 1136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	525/894 (59%)
atp8a1	XP_073778311.1	None