Protein Alignment ATP8A and Atp8b5p

DIOPT Version :9

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_038966915.1
• Gene: Atp8b5p / 691125
• RGDID: 1587460
• Length: 1191
• Species: Rattus norvegicus
• Alignment Length: 1184
• Identity: 455/1184 - (38%)
• Similarity: 678/1184 - (57%)
• Gaps: 128/1184 - (10%)

  Fly   206 SAGYDADDGER------RIINLNGPQPT---KYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFF 261
            ||.|:.::.:|      ||:..|..:..   :|.:|.|.|:||||.:|||..|||||:|.:|.:|
  Rat    20 SAMYERENEQRQNEEEERILQANNRRFNSLFEYPDNSIKTSKYSFFNFLPVNLFEQFQRLANAYF 84

  Fly   262 LLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDI------------KRHRADNEINHRS 314
            |::..||.||::|....|||::||:.:||::.:|:.|:|:            |||::|.::|:||
  Rat    85 LILLFLQLIPQISSLAWYTTVIPLIVVLSITGVKDAIDDVVKWLPGLPSLHLKRHQSDQQVNNRS 149

  Fly   315 IERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQA 379
            :..|.:|.....:|..:.||||||:..:....||::|||||||..:.:||||:||||||||::||
  Rat   150 VLILVNGRIEENKWRNVQVGDIIKLENDHPVTADVLLLSSSEPYGLTYIETADLDGETNLKVKQA 214

  Fly   380 LPATAELLETKD-LQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWV 443
            :.||:::.:..: |....|.:.||.||..|..|:|.|...| ....|..:::|.||.|:|||.|.
  Rat   215 VSATSDMEDNLELLSAFNGEVRCEPPNNKLDRFSGTLSYLG-DTYFLDYERLLLRGCIIRNTDWC 278

  Fly   444 FGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTRE---HSE 505
            :|:|||:|.:||||:||..:..||:.:|.|.|..:|.:||:|..:|.:..:.:..|...   |.:
  Rat   279 YGLVVYTGPDTKLMQNSGRSTFKRTHIDHLMNVLVLWIFMLLGGMCFLLSIGHGIWESNRGYHFQ 343

  Fly   506 TDWYLGLTDFKTKSLGYNLLTF---FILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNT 567
            .  :|....:.|.|...:.|.|   ||:.|.::||||.|::|::|...:.:||:|.:|::...||
  Rat   344 A--FLPWERYITSSAASSALAFWSYFIVLNTMVPISLYVSVEIIRLGNSYYINWDRKMFYAPKNT 406

  Fly   568 PAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY---------TAERTPE----- 618
            ||.|||:.||||||.|:|:|||||||||:|||.|.||||.|..|         ...::|.
  Rat   407 PAQARTTTLNEELGQVEYVFSDKTGTLTENVMIFNKCSINGKTYGYSYDENGQCVPKSPSNKVDF 471

  Fly   619 -------------ESQLVQNILGRHETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERA 670
                         :..||:.:  :.|...|...|| .||:||||:.|.|..|.::|.|.||||.|
  Rat   472 SYNHLADPKFSFYDKTLVEAV--KSEDPLVYLFFL-CLSLCHTVMSEEKVEGELVYQAQSPDEGA 533

  Fly   671 LVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGAD 735
            ||..::.||::|.:|||:.:.:..:|..:.|.:|.:|:|::.|||||:||:|||:::.|||||||
  Rat   534 LVTASRNFGFVFHSRTPETITVIEMGRVRVYRLLAILDFSNERKRMSVIVQTPEDRVMLFCKGAD 598

  Fly   736 TVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESK 800
            |:|||.|.|...|..:.|:..|::|||:|||||.:|..::....:|.|.:...:|.:.|:|||.|
  Rat   599 TIIYELLHPSCAALSDVTMDQLDDFASEGLRTLMVAYRELDKAFFQTWIKKHGEAWLTLENREKK 663

  Fly   801 LEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISH 865
            |......||.:|.|||||||||:||.||||||.:|..|.|.||||||||||||:||.||||:...
  Rat   664 LALVYEEIERDLVLLGATAIEDKLQSGVPETIVTLNKAKIKIWVLTGDKQETAVNIAYSCRIFKD 728

  Fly   866 SMDIIILNE--------ESLDATRE----------------VIHRHYGEFKS-SSAKDANVALVI 905
            .||.:.:.|        |.|...|:                :..:....||: ....:.:..|||
  Rat   729 EMDAVFMVEGTDRETVLEELRTARKKMKPESLLESDPINIYLARKSKMPFKAVDEVPNGSYGLVI 793

  Fly   906 DGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMI 970
            .|.:|.|||..:...:......:|:.|:|||::|:|||:||::|.:....|||||||||||:.||
  Rat   794 SGCSLAYALESNTEFELLRTACMCKGVVCCRMTPLQKAQVVDLVKRYKKVVTLAIGDGANDIGMI 858

  Fly   971 QKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIEL 1035
            :.|::|:||||.||:||..:||:|..|||||||||||||.|:|.|:.|.:.|.||||....::..
  Rat   859 KAAHIGVGISGQEGMQATLSSDFSFCQFRYLQRLLLVHGRWSYNRMCKFLSYFFYKNFAFTLVHF 923

  Fly  1036 WFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVK 1100
            |:|.::|:|.|.:::.|.|..||:::|::|...:.||||.......:.||.||:..|:...||.|
  Rat   924 WYAFFNGFSAQTVYDIWFITFYNLIYTSLPILGLSLFEKDVNETWSLCYPELYEPGQHNLYFNKK 988

  Fly  1101 VFWIWIFNALLHSVF----LFWLPL-AAYTKEVIWSDGK-TSDYLLMGNLVYTYVIVTVCLKAGL 1159
            .|    ...|||.::    ||::|: ..:..|  .|||| .||:.....||.|.:|..:.::..|
  Rat   989 EF----IKCLLHGIYSSFVLFFVPMGTVFNSE--RSDGKDISDFQSFSLLVQTTLIWVMTMQIAL 1047

  Fly  1160 ITNSWTWLTHLAIWGSIVLWFG--FLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPIT 1222
            .|..||.:.|...|||:.|:|.  |||....:..||....||.|:....|:.|..:.||:|..:.
  Rat  1048 STTYWTMINHAFTWGSLGLYFCILFLLCSDGLCLMFPSVFNFLGVARNGLNQPQMWLCLVLSSVL 1112

  Fly  1223 TLL----------------IDVICKLVHNTVFKTLTE----AVRETEIRRSDISEVMNEPRSSDS 1267
            .|:                :|.:...:|..:...|..    .|:...:|||..:      .|...
  Rat  1113 CLIPLMGYNFLKPILWPINVDKVLNRIHFCLKHPLPPPVQIKVKHPGLRRSAYA------FSHKQ 1171

  Fly  1268 GFGYAL--GKLIRS 1279
            |||..:  ||.::|
  Rat  1172 GFGALITSGKTLKS 1185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	27/64 (42%)
		ATPase-Plipid	229..1247	CDD:273734	438/1116 (39%)
		E1-E2_ATPase	286..>371	CDD:278548	36/96 (38%)
		Cation_ATPase	645..741	CDD:289987	47/95 (49%)
		HAD_like	<942..1001	CDD:304363	34/58 (59%)
		PhoLip_ATPase_C	988..1240	CDD:292829	92/275 (33%)
Atp8b5p	XP_038966915.1	P-type_ATPase_APLT_Dnf-like	54..1008	CDD:319770	397/963 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830