Protein Alignment ATP8A and Atp8b2

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_001062555.3
• Gene: Atp8b2 / 685152
• RGDID: 1597731
• Length: 1209
• Species: Rattus norvegicus
• Alignment Length: 1179
• Identity: 470/1179 - (39%)
• Similarity: 700/1179 - (59%)
• Gaps: 104/1179 - (8%)

  Fly   228 KYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVS 292
            :|.:|.|.|:||:.::|||..|||||:..:|.:||.:.|||.||::|....:||:|||:.:|:::
  Rat    47 QYASNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTIT 111

  Fly   293 AIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEP 357
            |:|:..:|..||::||::|.|..:.|.:|.....:|..:.||||||:..|.|..|||:|||||||
  Rat   112 AVKDATDDYFRHKSDNQVNSRHSQVLINGVLQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEP 176

  Fly   358 QAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRETG-KP 421
            ..:|:|||:.||||||:|:|||:|.|:||.:...|.:.:|.:.||.||..|.:|:|.|...| |.
  Rat   177 HGLCYIETSELDGETNMKVRQAIPVTSELGDISQLAKFDGEVICEPPNNKLDKFSGALYWKGNKF 241

  Fly   422 PAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILI 486
            |  |.|..:|.||.:||||.|.||:|:::|.:||||:||.....||:::|:|.||.:|.:|..|:
  Rat   242 P--LSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLV 304

  Fly   487 SLCIISGLCNLFWTRE-HSETDWYLGLTDFKTKSLGYNLLTFF---ILYNNLIPISLQVTLELVR 547
            .:.:|..:.|..|..| .:....||...:....:.....|:|:   |:.|.::||||.|::|::|
  Rat   305 CMGVILAIGNAIWEHEVGTRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIR 369

  Fly   548 FLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY- 611
            ...:.|||:|.:|:..:..|||.|||:.||||||.|:|||||||||||||:|.|.||||.|:.|
  Rat   370 LGHSYFINWDKKMFCMKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSYG 434

  Fly   612 -----------TAERTPE-----------------ESQLVQNI-LGRHETSAVIEEFLELLSVCH 647
                       ..|| ||                 :..|::.: :|...|    .||..|||:||
  Rat   435 DVFDVLGHKAELGER-PEPVDFSFNPLADKKFLFWDPSLLEAVKMGDPHT----HEFFRLLSLCH 494

  Fly   648 TVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSS 712
            ||:.|.|..|.:.|.|.||||.|||..|:.||::|.:||||.|.::.||....|::|.:|:|.:.
  Rat   495 TVMSEEKNEGELYYKAQSPDEGALVTAARNFGFVFRSRTPKTVTVHELGTSITYQLLAILDFNNI 559

  Fly   713 RKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRP 777
            |||||:|||.||.||:|:||||||::.:||.|..|.....|..||.|:|.||||||.||..|:..
  Rat   560 RKRMSVIVRNPEGKIRLYCKGADTILLDRLHPSTQELLNSTTDHLNEYAGDGLRTLVLAYKDLDE 624

  Fly   778 DVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYI 842
            :.|:||::...:||:|..:||.:|......:|:::.|||||||||:||.|||||||.|..|.|.|
  Rat   625 EYYEEWARRRLQASLAQDSREDRLASIYEEVESDMMLLGATAIEDKLQQGVPETIALLTLANIKI 689

  Fly   843 WVLTGDKQETAINIGYSCRLISHSM-DIIILNEESLDATREVIHR-----------------HYG 889
            |||||||||||:||||||::::..| ::.|:...::...||.:.:                 :.|
  Rat   690 WVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTGHTVLEVREELRKARKKMVDSSHAVGNGFTYQG 754

  Fly   890 EFKSS------SAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEM 948
            ...||      .|.....||||:|.:|.:||..|:..:|.:....|:.||||||:|:|||:|||:
  Rat   755 NLSSSKLTSVLEAVAGEYALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVEL 819

  Fly   949 VTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNY 1013
            |.:...|||||||||||||:||:.|::|:||||.||:||..|||||.:||::|||||||||.|:|
  Rat   820 VKKYKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSY 884

  Fly  1014 ARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTA 1078
            .|:.|.:.|.||||....::..||..:.|:|.|.:::::.|.|||:::|::|..|||:|::....
  Rat   885 LRMCKFLCYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPE 949

  Fly  1079 ETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDG-KTSDYLLMG 1142
            :..:.||.||:..|...|||.:.|:|.|...:..||.:|::|...:. |....|| :.:||....
  Rat   950 QRSMEYPKLYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFA-EATRDDGTQLADYQSFA 1013

  Fly  1143 NLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLL-IYSH-VWPMFKFASNFRGMDIQ 1205
            ..|.|.:::.|.::.||.|..||.:.|..||||:.::|..|. ::|: ::.||.....|.|....
  Rat  1014 VTVATSLVIVVSVQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQFRFVGNAQN 1078

  Fly  1206 LLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEI-------------------- 1250
            .|:.|..:..::|.....::..|..:.:..::...|::.||.|::
  Rat  1079 TLAQPTVWLTIVLTTAVCIMPVVAFRFLRLSLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTGS 1143

  Fly  1251 RRSDISEVMNEPRSSDSGFGYAL--GKLIRSSHILISHDHHPVSESSRTSNLRVENLEMEADTEQ 1313
            |||..:      .|...|||..:  ||.:|.|.:.:|      |.|:|:|:..:|:|..:.....
  Rat  1144 RRSGYA------FSHQEGFGELIMSGKNMRLSSLALS------SFSTRSSSSWIESLRRKKSDSA 1196

  Fly  1314 QQQSRQRQK 1322
            ...|...:|
  Rat  1197 NSPSGGAEK 1205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	415/947 (44%)
Atp8b2	XP_001062555.3	P-type_ATPase_APLT_Dnf-like	50..991	CDD:319770	415/947 (44%)
		Cation_ATPase_C	929..1104	CDD:376368	51/175 (29%)