DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and atp8b1

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_001025562.1	Gene:	atp8b1 / 594952	XenbaseID:	XB-GENE-490143	Length:	1250	Species:	Xenopus tropicalis

Alignment Length:	1269	Identity:	472/1269 - (37%)
Similarity:	711/1269 - (56%)	Gaps:	126/1269 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 DSDTPNTPVTPVSGLQPPASVSTSVGGTLSSRRRSSNRKDSKGSILSRQSGKSRVSLLAQRGLRM 185
            ||..||..|.|.|..:....:.:.........||:...:.|:..::...:.:.:.
Frog    12 DSQVPNDDVVPYSDDETDDELDSPQTDEPEQNRRNVQAEQSREPVIKECTWQVKA---------- 66

  Fly   186 TASFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLF 250
                         :|.:|     ||..:.::::...  .:.:||..|.|.|.||:.|:|||..|:
Frog    67 -------------NDRNF-----YDQPEFKKKVFLC--LKKSKYAGNAIKTYKYNPITFLPVNLY 111

  Fly   251 EQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSI 315
            |||:|.:|.:||::.|||.||::|.....|||:||:.:|.::|||::::||.||:.|||||:|..
Frog   112 EQFKRAANAYFLVLLILQTIPQISTVTWSTTLIPLLLVLGITAIKDLVDDIARHKMDNEINNRPS 176

  Fly   316 ERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQAL 380
            |.:..|.:...:|..:.|||||::..|.|.|||::|||||:|.::|::|||.||||||||.:.:|
Frog   177 EVITDGRFKKTKWKHIHVGDIIRINKNEFVPADVLLLSSSDPNSLCYVETAELDGETNLKFKMSL 241

  Fly   381 PATAELLETKD-LQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVF 444
            ..|.:||:.:: |...:|.:|||.||..|.:|.|.|...|. ...|..|::|.||..:|||.:..
Frog   242 EITDKLLQKEEQLAGFDGLVECEEPNNRLDKFVGTLFWRGN-SFGLDADKILLRGCTVRNTEYCH 305

  Fly   445 GIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTRE--HSETD 507
            |:|:::|.:||:|:||....|||:.:|.|.|..:..:|::||.......:...||..:  .:...
Frog   306 GLVLFAGADTKIMRNSGKTRLKRTKIDYLMNYMVYTIFVLLILAAAGLAIGQTFWEAKLGAANVS 370

  Fly   508 WYLGLTDFKTKSLGY-NLLTFF---ILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTP 568
            ||  |.|....|..| ..|.|:   |:.|.::||||.|::|::|..|:.|||:|::||....:||
Frog   371 WY--LYDGNNYSPSYRGFLAFWGYIIVLNTMVPISLYVSVEVIRLGQSYFINWDLQMYFSPKDTP 433

  Fly   569 AMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAER------------------ 615
            |.|||:.|||:||.::|||||||||||||:|.||||:|.|..|..:.
Frog   434 AKARTTTLNEQLGQIQYIFSDKTGTLTQNIMTFKKCTINGTTYGDDDDELKSGQTKQVDFSWNPL 498

  Fly   616 -----TPEESQLVQNILGRHETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGA 675
                 |..::.|::.|  |......:.||.:||::||||:.| |.:|.:||.||||||.|||..|
Frog   499 ADPSFTFHDNYLIEQI--RAGKDKDVYEFFKLLALCHTVMAE-KTDGELIYQAASPDEGALVTAA 560

  Fly   676 QKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYE 740
            :.||::|.:||...:.|:.||..|.||||.:|:|.|.|||||:|||.|:.:|:|:||||||||||
Frog   561 RNFGFVFLSRTQSTITISELGQEKTYEVLAILDFNSDRKRMSIIVRQPDGRIRLYCKGADTVIYE 625

  Fly   741 RLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAA 805
            ||.|. ...::||.:.|:.||:..||||||...||....::.||:.:.:||||..||:..|:...
Frog   626 RLHPD-NPIKDQTQKALDIFANASLRTLCLCYKDINKGDFENWSKKYKQASVATSNRDEALDRVY 689

  Fly   806 NLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRL------IS 864
            ..||.:|:|||||||||:|||.|..||.:|..|.|.||||||||:|||.||||||:|      |.
Frog   690 EAIETDLKLLGATAIEDKLQDDVSGTIFNLARADIKIWVLTGDKKETAENIGYSCKLLDDDTEIL 754

  Fly   865 HSMDIIILNEESLDATREVIHRHYGEFKSSSA----KDANVALVIDGTTLK-------------- 911
            :..||.:..:..::..|..:..:.|...:.|.    .|...||:|.|:.|.
Frog   755 YGEDINVHLQTRMENQRNQMSGNQGAQSNQSGAFLPTDKKHALIITGSWLNEILLEKKKRKKKRL 819

  Fly   912 ---------------------YALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNA 955
                                 |||....:..|.||...|..||||||:|.|||.||::|.:...|
Frog   820 KLKFPRTKEEKEQQLHEKLKAYALKEQRQRSFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKA 884

  Fly   956 VTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLI 1020
            ||||||||||||.||:.|::|:||||.||:||..:||||.||||||||||||||.|:|.|:.|.:
Frog   885 VTLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFL 949

  Fly  1021 LYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYP 1085
            .|.||||....::..|::.::|:|.|.::|.|.|.|||||::::|...:||.::..:.:..:.:|
Frog   950 RYFFYKNFSFTLVHFWYSFFNGFSAQTVYEDWFITLYNVLYSSLPVLLVGLLDQDVSDKLSLAFP 1014

  Fly  1086 MLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKT-SDYLLMGNLVYTYV 1149
            .||...|...|||.|.|::.:|:.::.|:.:|::|..|:.. .:..||:. |||........|.:
Frog  1015 RLYVPGQKDLLFNYKKFFLSLFHGIVTSLIIFFIPYGAFLL-TMGQDGEAPSDYQSFAVTTATAL 1078

  Fly  1150 IVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLL-IYS---HVWPMFKFASNFRGMDIQLLSTP 1210
            ::||..:.||.|:.||::...:|:|||.::||.:. ::|   ||  :|.....|.|.....|..|
Frog  1079 VITVNFQIGLDTSYWTFVNAFSIFGSIAIYFGIMFDLHSAGIHV--LFPSMFIFTGAAPNALRQP 1141

  Fly  1211 VFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRSSDSGFGYALGK 1275
            ..:..::|.....||..|..:.:..|::.:.::.:::...:.....|...:|:.      :|.|.
Frog  1142 YLWLTIILTVAFCLLPIVALRFLAKTIWPSESDKIQKKGKKFKAEVEQRAKPKP------FARGV 1200

  Fly  1276 LIRSSHILISHDHHPVSESSRTSNLRVENLEMEA 1309
            ..|.|....||........|...::|.:...::|
Frog  1201 STRRSAYAFSHQRGYADLISSGRSIRKKRASLDA 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	25/61 (41%)
		ATPase-Plipid	229..1247	CDD:273734	446/1097 (41%)
		E1-E2_ATPase	286..>371	CDD:278548	39/84 (46%)
		Cation_ATPase	645..741	CDD:289987	55/95 (58%)
		HAD_like	<942..1001	CDD:304363	38/58 (66%)
		PhoLip_ATPase_C	988..1240	CDD:292829	88/256 (34%)
atp8b1	NP_001025562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		9/39 (23%)
atp8b1	NP_001025562.1	P-type_ATPase_APLT_Dnf-like	92..1049	CDD:319770	411/963 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930