Protein Alignment ATP8A and ATP10D

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_065186.3
• Gene: ATP10D / 57205
• HGNCID: 13549
• Length: 1426
• Species: Homo sapiens
• Alignment Length: 1469
• Identity: 436/1469 - (29%)
• Similarity: 674/1469 - (45%)
• Gaps: 387/1469 - (26%)

  Fly   154 RSSNRKDSKG-----SILSRQSGKSRVSLLAQRGLRMTASFLRRKRTEYEDDEDFTSSAGYDADD 213
            |.:.|.|..|     |:|:.....|:...|:.|. |:....::..:.||   |.|:.:
Human    17 RGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRH-RIVVPHIQPFKDEY---EKFSGA------- 70

  Fly   214 GERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGR 278
                           |.||||.|.||:.::|:|..|||||.|.:|.:||.:.:|..:|.|....:
Human    71 ---------------YVNNRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQK 120

  Fly   279 YTTLVPLMFILSVSAIKEIIEDIKRHRADNEINH-----------RSIERLDSGSWCTVRWSELT 332
            ..|::||:.:|::.|||:.:||.::::.|.:||:           :.|:|      |   |.::|
Human   121 EITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDR------C---WKDVT 176

  Fly   333 VGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEG 397
            |||.|::..|...|||::||.|::|..:|.|||:.||||:|||.||.:...||.....|.::...
Human   177 VGDFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSS 241

  Fly   398 RIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTS 462
            |||||.||..|..|.|.|..:.|....|..:.:|.||..:|||..|.|||||:|.|||.|.|::.
Human   242 RIECESPNNDLSRFRGFLEHSNKERVGLSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSG 306

  Fly   463 APLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHS--------ETDWYL---GLTDFK 516
            ...|||.:::..||.:|...|:|:.:|:...:.:..|...:.        |.|.::   .|..|
Human   307 PRYKRSKLERRANTDVLWCVMLLVIMCLTGAVGHGIWLSRYEKMHFFNVPEPDGHIISPLLAGF- 370

  Fly   517 TKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELG 581
                 |...|..||...||||||.|::|:|:..|..||..|::.|:|:.::....|..|:.|:||
Human   371 -----YMFWTMIILLQVLIPISLYVSIEIVKLGQIYFIQSDVDFYNEKMDSIVQCRALNIAEDLG 430

  Fly   582 MVKYIFSDKTGTLTQNVMEFKKCSIAGYVYT-----------AERTPEESQLVQNILG------- 628
            .::|:|||||||||:|.|.|::||:||:.|.           .|...|:...:..:.|
Human   431 QIQYLFSDKTGTLTENKMVFRRCSVAGFDYCHEENARRLESYQEAVSEDEDFIDTVSGSLSNMAK 495

  Fly   629 -------------------RH-----------------------------ETSAV---------- 635
                               .|                             ||..|
Human   496 PRAPSCRTVHNGPLGNKPSNHLAGSSFTLGSGEGASEVPHSRQAAFSSPIETDVVPDTRLLDKFS 560

  Fly   636 -----------------------IEEFLELLSVCHTVI--------------------------- 650
                                   |.:|...|::|:||:
Human   561 QITPRLFMPLDETIQNPPMETLYIIDFFIALAICNTVVVSAPNQPRQKIRHPSLGGLPIKSLEEI 625

  Fly   651 ---------------------------------------------PERKE--------------- 655
                                                         |..:|
Human   626 KSLFQRWSVRRSSSPSLNSGKEPSSGVPNAFVSRLPLFSRMKPASPVEEEVSQVCESPQCSSSSA 690

  Fly   656 ---------------NG------------NMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEIN 693
                           ||            |:.|.|.||||.|||..|:.:.....:|||:.|.::
Human   691 CCTETEKQHGDAGLLNGKAESLPGQPLACNLCYEAESPDEAALVYAARAYQCTLRSRTPEQVMVD 755

  Fly   694 --ALGVRKRYEVLNVLEFTSSRKRMSLIVRTP-ENKIKLFCKGADTVIYERL---APQGQAF--- 749
              ||| ...:::|::|.|.|.|||||::||.| .|::.::.||||:||.|.|   :|.|.:.
Human   756 FAALG-PLTFQLLHILPFDSVRKRMSVVVRHPLSNQVVVYTKGADSVIMELLSVASPDGASLEKQ 819

  Fly   750 ----REQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIEN 810
                ||:|.:||:::|..||||||:|...:....|.||.:....|..::.|||..|.::|..:||
Human   820 QMIVREKTQKHLDDYAKQGLRTLCIAKKVMSDTEYAEWLRNHFLAETSIDNREELLLESAMRLEN 884

  Fly   811 NLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEE 875
            .|.|||||.||||||:||||:|.:|..|||.||:|||||||||:||.|:|:|:.....:.|||.:
Human   885 KLTLLGATGIEDRLQEGVPESIEALHKAGIKIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQ 949

  Fly   876 SLDATREVIHRHYGEFKSSS------------------AKDANV--ALVIDGTTLKYALSCDLRN 920
            |.||...::.....|.:..:                  .:|:.:  .|:|.|.||::||...|:.
Human   950 SKDACGMLMSTILKELQKKTQALPEQVSLSEDLLQPPVPRDSGLRAGLIITGKTLEFALQESLQK 1014

  Fly   921 DFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGL 985
            .|.:|...|:.|:|||.:|:||:|||::|......:|||||||||||:|||.|::|||:||.||:
Human  1015 QFLELTSWCQAVVCCRATPLQKSEVVKLVRSHLQVMTLAIGDGANDVSMIQVADIGIGVSGQEGM 1079

  Fly   986 QAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFE 1050
            ||..|||::::||::|.:||||||.|.|.|:|.:|||.|||||....:..|:..:.|:||..:.:
Human  1080 QAVMASDFAVSQFKHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTD 1144

  Fly  1051 RWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVF 1115
            .|.:..:|:|||:.||...|:.||..:|||:::.|.||::.|.::.:....|||.:.:|...|:.
Human  1145 YWVLIFFNLLFTSAPPVIYGVLEKDVSAETLMQLPELYRSGQKSEAYLPHTFWITLLDAFYQSLV 1209

  Fly  1116 LFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWF 1180
            .|::|...|       .|..:|....||.:.|..:..|.|...:.:.|.||:..|.|.|||:.:|
Human  1210 CFFVPYFTY-------QGSDTDIFAFGNPLNTAALFIVLLHLVIESKSLTWIHLLVIIGSILSYF 1267

  Fly  1181 GFLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAV 1245
            .|.:::..:.......||...:..:.:..||||...:|.....||...:.:::..::|.:
Human  1268 LFAIVFGAMCVTCNPPSNPYWIMQEHMLDPVFYLVCILTTSIALLPRFVYRVLQGSLFPS----- 1327

  Fly  1246 RETEIRRSDISEVMNEPRSSDSGFGYALGKLIRSSHILISHDHHPVSESSRTSNLRVENLEMEAD 1310
                                         .::|:.|.                    :.|..|
Human  1328 -----------------------------PILRAKHF--------------------DRLTPE-- 1341

  Fly  1311 TEQQQQSRQRQKWRG----GQVATGVA-RSARNSTTSPI 1344
                ::::..:||||    .||.:..| :||..|...|:
Human  1342 ----ERTKALKKWRGAGKMNQVTSKYANQSAGKSGRRPM 1376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	377/1156 (33%)
ATP10D	NP_065186.3	P-type_ATPase_APLT_Dnf-like	73..1214	CDD:319770	377/1156 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..531		1/24 (4%)