DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8A and ATP8B2

DIOPT Version :9

Sequence 1:NP_001137651.1 Gene:ATP8A / 36488 FlyBaseID:FBgn0259221 Length:1350 Species:Drosophila melanogaster
Sequence 2:NP_001354863.1 Gene:ATP8B2 / 57198 HGNCID:13534 Length:1209 Species:Homo sapiens


Alignment Length:1236 Identity:473/1236 - (38%)
Similarity:720/1236 - (58%) Gaps:142/1236 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 RKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRY 256
            ||:..:..:|:..:.|. |.:..|:          .:|.:|.|.|:||:.::|||..|||||:..
Human    22 RKKPSWGTEEERRARAN-DREYNEK----------FQYASNCIKTSKYNILTFLPVNLFEQFQEV 75

  Fly   257 SNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSG 321
            :|.:||.:.|||.||::|....:||:|||:.:|:::|:|:..:|..||::||::|:|..:.|.:|
Human    76 ANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNNRQSQVLING 140

  Fly   322 SWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAEL 386
            .....:|..:.||||||:..|.|..|||:|||||||..:|:||||.||||||:|:|||:|.|:||
Human   141 ILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSEL 205

  Fly   387 LETKDLQRLEGRIECELPNRHLYEFNGVL--RETGKPPAALGNDQVLQRGAILRNTAWVFGIVVY 449
            .:...|.:.:|.:.||.||..|.:|:|.|  :|...|   |.|..:|.||.:||||.|.||:|::
Human   206 GDISKLAKFDGEVICEPPNNKLDKFSGTLYWKENKFP---LSNQNMLLRGCVLRNTEWCFGLVIF 267

  Fly   450 SGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHS---------- 504
            :|.:||||:||.....||:::|:|.||.:|.:|..|:.:.:|..:.|..|  ||.          
Human   268 AGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIW--EHEVGMRFQVYLP 330

  Fly   505 -----ETDWYLGLTDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEE 564
                 ::.::.|...|         .::.|:.|.::||||.|::|::|...:.|||:|.:|:..:
Human   331 WDEAVDSAFFSGFLSF---------WSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCMK 386

  Fly   565 SNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY------------TAERTP 617
            ..|||.|||:.||||||.|:|||||||||||||:|.|.||||.|:.|            ..|| |
Human   387 KRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSYGDVFDVLGHKAELGER-P 450

  Fly   618 E-----------------ESQLVQNI-LGRHETSAVIEEFLELLSVCHTVIPERKENGNMIYHAA 664
            |                 :..|::.: :|...|    .||..|||:||||:.|.|..|.:.|.|.
Human   451 EPVDFSFNPLADKKFLFWDPSLLEAVKIGDPHT----HEFFRLLSLCHTVMSEEKNEGELYYKAQ 511

  Fly   665 SPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKL 729
            ||||.|||..|:.||::|.:||||.:.::.:|....|::|.:|:|.:.|||||:|||.||.||:|
Human   512 SPDEGALVTAARNFGFVFRSRTPKTITVHEMGTAITYQLLAILDFNNIRKRMSVIVRNPEGKIRL 576

  Fly   730 FCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVAL 794
            :||||||::.:||....|.....|:.||.|:|.:|||||.||..|:..:.|:||::...:||:|.
Human   577 YCKGADTILLDRLHHSTQELLNTTMDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAERRLQASLAQ 641

  Fly   795 QNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYS 859
            .:||.:|......:|||:.|||||||||:||.|||||||.|..|.|.||||||||||||:|||||
Human   642 DSREDRLASIYEEVENNMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYS 706

  Fly   860 CRLISHSMDIIIL----------------NEESLDATREVIHRHYGEFKSSSAKDANV------- 901
            |::::..|..:.:                .|:.:|::|.|.:....:.|.||:|..:|       
Human   707 CKMLTDDMTEVFIVTGHTVLEVREELRKAREKMMDSSRSVGNGFTYQDKLSSSKLTSVLEAVAGE 771

  Fly   902 -ALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGAN 965
             ||||:|.:|.:||..|:..:|.:....|:.||||||:|:|||:|||:|.:...|||||||||||
Human   772 YALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGAN 836

  Fly   966 DVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCL 1030
            ||:||:.|::|:||||.||:||..|||||.:||::|||||||||.|:|.|:.|.:.|.||||...
Human   837 DVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAF 901

  Fly  1031 YVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAK 1095
            .::..||..:.|:|.|.:::::.|.|||:::|::|..|||:|::....:..:.||.||:..|...
Human   902 TMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNL 966

  Fly  1096 LFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDG-KTSDYLLMGNLVYTYVIVTVCLKAGL 1159
            |||.:.|:|.|...:..||.:|::|...:. :....|| :.:||......|.|.:::.|.::.||
Human   967 LFNKREFFICIAQGIYTSVLMFFIPYGVFA-DATRDDGTQLADYQSFAVTVATSLVIVVSVQIGL 1030

  Fly  1160 ITNSWTWLTHLAIWGSIVLWFGFLL-IYSH-VWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPIT 1222
            .|..||.:.|..||||:.::|..|. ::|: ::.||.....|.|.....|:.|..:..::|..:.
Human  1031 DTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVV 1095

  Fly  1223 TLLIDVICKLVHNTVFKTLTEAVRETE-IRRSDISE---VMNEPRSSDSGFGYA------LGKLI 1277
            .::..|..:.:...:...|::.||.|: :|:...::   :....|:.....|||      .|:||
Human  1096 CIMPVVAFRFLRLNLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTGSRRSGYAFSHQEGFGELI 1160

  Fly  1278 RSSHILISHDHHPVSESSRTSNLRVENLEMEADTEQQQQSRQRQKWRGGQVATGVARSARNSTTS 1342
            .|.                 .|:|:.:|.:.:.|     :|....|     ...:.|...:|.:|
Human  1161 MSG-----------------KNMRLSSLALSSFT-----TRSSSSW-----IESLRRKKSDSASS 1198

  Fly  1343 P 1343
            |
Human  1199 P 1199

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8ANP_001137651.1 PhoLip_ATPase_N 218..280 CDD:292826 23/61 (38%)
ATPase-Plipid 229..1247 CDD:273734 446/1091 (41%)
E1-E2_ATPase 286..>371 CDD:278548 38/84 (45%)
Cation_ATPase 645..741 CDD:289987 48/95 (51%)
HAD_like <942..1001 CDD:304363 38/58 (66%)
PhoLip_ATPase_C 988..1240 CDD:292829 83/254 (33%)
ATP8B2NP_001354863.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 3/13 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1181..1209 5/24 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X168
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.730

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