Protein Alignment ATP8A and ATP10A

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_077816.1
• Gene: ATP10A / 57194
• HGNCID: 13542
• Length: 1499
• Species: Homo sapiens
• Alignment Length: 1430
• Identity: 439/1430 - (30%)
• Similarity: 673/1430 - (47%)
• Gaps: 322/1430 - (22%)

  Fly   138 PASVSTSVGGTLSSRRRSSNRKDSKGSILSRQSGKSRVSLLAQRGLRMTASFLRRKRTEYEDDED 202
            ||  .|...|....|||...|..:..|.|....|....:..|.:|.|      ||:|
Human     5 PA--GTEEPGPPGRRRRREGRTRTVRSNLLPPPGAEDPAAGAAKGER------RRRR-------- 53

  Fly   203 FTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAIL 267
              ..|.:.||                   ||:.|.||:.:||||..|||||.|.:|.:|:.||:|
Human    54 --GCAQHLAD-------------------NRLKTTKYTLLSFLPKNLFEQFHRPANVYFVFIALL 97

  Fly   268 QQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRS--IERLDSGSWCTVRWSE 330
            ..:|.|:.......|.|::|||:::|.:::.||..|||:|::|||..  :...:...:....|.|
Human    98 NFVPAVNAFQPGLALAPVLFILAITAFRDLWEDYSRHRSDHKINHLGCLVFSREEKKYVNRFWKE 162

  Fly   331 LTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRL 395
            :.|||.:::..|..||||::|||||:|..:|.|||||||||||||.||.:...:||:...:....
Human   163 IHVGDFVRLRCNEIFPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEFNPLTF 227

  Fly   396 EGRIECELPNRHLYEFNG-VLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKN 459
            ...||||.||..|..|.| ::.:.|| .|.|..:.:|.||..||||..|.|||:|:|.|||.:.|
Human   228 TSVIECEKPNNDLSRFRGCIIHDNGK-KAGLYKENLLLRGCTLRNTDAVVGIVIYAGHETKALLN 291

  Fly   460 STSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETD--WYLGLTDFKTKS--- 519
            ::....|||.:::..|..:|...::|:.:.:.|.:.:..|...:.|..  :|:..:|..:.|
Human   292 NSGPRYKRSKLERQMNCDVLWCVLLLVCMSLFSAVGHGLWIWRYQEKKSLFYVPKSDGSSLSPVT 356

  Fly   520 -LGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMV 583
             ..|:.||..|:...||||||.|::|:|:..|..|||.|:::|.||:::....|..|:.|:||.:
Human   357 AAVYSFLTMIIVLQVLIPISLYVSIEIVKACQVYFINQDMQLYDEETDSQLQCRALNITEDLGQI 421

  Fly   584 KYIFSDKTGTLTQNVMEFKKCSIAGYVYT-----------AERTPEESQLV--------QNILGR 629
            :|||||||||||:|.|.|::|:::|..|:           .|...||.::|        :..:|.
Human   422 QYIFSDKTGTLTENKMVFRRCTVSGVEYSHDANAQRLARYQEADSEEEEVVPRGGSVSQRGSIGS 486

  Fly   630 HETSAVIE--------------------------------------------------------- 637
            |::..|:.
Human   487 HQSVRVVHRTQSTKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPDPKLLEKVSECDKSLAVA 551

  Fly   638 ------------------EFLELLSVCHTVI---------------------------------- 650
                              :|...|::|:||:
Human   552 RHQEHLLAHLSPELSDVFDFFIALTICNTVVVTSPDQPRTKVRVRFELKSPVKTIEDFLRRFTPS 616

  Fly   651 ----------------------------------------------------------------- 650
                                                                             
Human   617 CLTSGCSSIGSLAANKSSHKLGSSFPSTPSSDGMLLRLEERLGQPTSAIASNGYSSQADNWASEL 681

  Fly   651 -PERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKY--VEINALGVRKRYEVLNVLEFTSS 712
             .|::....:.|.|.||||.|||..|:.:..:...|....  ||:..|| |..:|:|:.|.|.|.
Human   682 AQEQESERELRYEAESPDEAALVYAARAYNCVLVERLHDQVSVELPHLG-RLTFELLHTLGFDSV 745

  Fly   713 RKRMSLIVRTP-ENKIKLFCKGADTVIYERLAP---------QGQAFREQTLRHLEEFASDGLRT 767
            |||||:::|.| .::|.::.||||:|:.:.|.|         ..:..|.:|..:|..:|::||||
Human   746 RKRMSVVIRHPLTDEINVYTKGADSVVMDLLQPCSSVDARGRHQKKIRSKTQNYLNVYAAEGLRT 810

  Fly   768 LCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETI 832
            ||:|...:..:.|..|.|:..:|..:|:|.|..|..:|..:|.||.|||||.|||||||||||||
Human   811 LCIAKRVLSKEEYACWLQSHLEAESSLENSEELLFQSAIRLETNLHLLGATGIEDRLQDGVPETI 875

  Fly   833 ASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDA------------------ 879
            :.|..||:.||||||||||||:||.|:|:|:.|..::|.||..|.:|
Human   876 SKLRQAGLQIWVLTGDKQETAVNIAYACKLLDHDEEVITLNATSQEACAALLDQCLCYVQSRGLQ 940

  Fly   880 -----TREVIHRHYGEF---KSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCR 936
                 |:..:...:...   .:|:|.....:|||||.:|.|||..:|.:.|..|...||.|:|||
Human   941 RAPEKTKGKVSMRFSSLCPPSTSTASGRRPSLVIDGRSLAYALEKNLEDKFLFLAKQCRSVLCCR 1005

  Fly   937 VSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYL 1001
            .:|:||:.||::|.....|:|||||||||||:|||.|:||:||||.||:||..|||:::.:||||
Human  1006 STPLQKSMVVKLVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPKFRYL 1070

  Fly  1002 QRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPP 1066
            :|||::||.|.|:|::.::||.||||.....:..||..:.|:|...:.::|.:..:|:||:::||
Human  1071 ERLLILHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFFCGFSASTMIDQWYLIFFNLLFSSLPP 1135

  Fly  1067 FAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWS 1131
            ...|:.::...|..::..|.|||:.||.:.:..:.||..:.:|...|:..|.:|..||....:
Human  1136 LVTGVLDRDVPANVLLTNPQLYKSGQNMEEYRPRTFWFNMADAAFQSLVCFSIPYLAYYDSNV-- 1198

  Fly  1132 DGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIY---------- 1186
                 |....|..:.|..::|..|..|:.|.:||||..:....|::|:|...|||
Human  1199 -----DLFTWGTPIVTIALLTFLLHLGIETKTWTWLNWITCGFSVLLFFTVALIYNASCATCYPP 1258

  Fly  1187 -SHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKT----LTEAVR 1246
             :..|.|           ..||..||||...::.|:..||..:..:.:...||.|    ..:..|
Human  1259 SNPYWTM-----------QALLGDPVFYLTCLMTPVAALLPRLFFRSLQGRVFPTQLQLARQLTR 1312

  Fly  1247 ETEIRRSDISEVMNEPR-SSDSGFGYALGKLIRSSHILISHDHHPVSESSRTSNLRVENLEMEAD 1310
            ::..|.|...|...:.| ..|||..::.|:.:::|        .|:|:.|..:...|.:||...:
Human  1313 KSPRRCSAPKETFAQGRLPKDSGTEHSSGRTVKTS--------VPLSQPSWHTQQPVCSLEASGE 1369

  Fly  1311  1310
            Human  1370  1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	369/1129 (33%)
ATP10A	NP_077816.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		16/55 (29%)
		P-type_ATPase_APLT_Dnf-like	61..1189	CDD:319770	370/1148 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..531		6/66 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1311..1356		13/52 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1464..1499