DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and ATP10A

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_077816.1	Gene:	ATP10A / 57194	HGNCID:	13542	Length:	1499	Species:	Homo sapiens

Alignment Length:	1430	Identity:	439/1430 - (30%)
Similarity:	673/1430 - (47%)	Gaps:	322/1430 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 PASVSTSVGGTLSSRRRSSNRKDSKGSILSRQSGKSRVSLLAQRGLRMTASFLRRKRTEYEDDED 202
            ||  .|...|....|||...|..:..|.|....|....:..|.:|.|      ||:|
Human     5 PA--GTEEPGPPGRRRRREGRTRTVRSNLLPPPGAEDPAAGAAKGER------RRRR-------- 53

  Fly   203 FTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAIL 267
              ..|.:.||                   ||:.|.||:.:||||..|||||.|.:|.:|:.||:|
Human    54 --GCAQHLAD-------------------NRLKTTKYTLLSFLPKNLFEQFHRPANVYFVFIALL 97

  Fly   268 QQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRS--IERLDSGSWCTVRWSE 330
            ..:|.|:.......|.|::|||:::|.:::.||..|||:|::|||..  :...:...:....|.|
Human    98 NFVPAVNAFQPGLALAPVLFILAITAFRDLWEDYSRHRSDHKINHLGCLVFSREEKKYVNRFWKE 162

  Fly   331 LTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRL 395
            :.|||.:::..|..||||::|||||:|..:|.|||||||||||||.||.:...:||:...:....
Human   163 IHVGDFVRLRCNEIFPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEFNPLTF 227

  Fly   396 EGRIECELPNRHLYEFNG-VLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKN 459
            ...||||.||..|..|.| ::.:.|| .|.|..:.:|.||..||||..|.|||:|:|.|||.:.|
Human   228 TSVIECEKPNNDLSRFRGCIIHDNGK-KAGLYKENLLLRGCTLRNTDAVVGIVIYAGHETKALLN 291

  Fly   460 STSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETD--WYLGLTDFKTKS--- 519
            ::....|||.:::..|..:|...::|:.:.:.|.:.:..|...:.|..  :|:..:|..:.|
Human   292 NSGPRYKRSKLERQMNCDVLWCVLLLVCMSLFSAVGHGLWIWRYQEKKSLFYVPKSDGSSLSPVT 356

  Fly   520 -LGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMV 583
             ..|:.||..|:...||||||.|::|:|:..|..|||.|:::|.||:::....|..|:.|:||.:
Human   357 AAVYSFLTMIIVLQVLIPISLYVSIEIVKACQVYFINQDMQLYDEETDSQLQCRALNITEDLGQI 421

  Fly   584 KYIFSDKTGTLTQNVMEFKKCSIAGYVYT-----------AERTPEESQLV--------QNILGR 629
            :|||||||||||:|.|.|::|:::|..|:           .|...||.::|        :..:|.
Human   422 QYIFSDKTGTLTENKMVFRRCTVSGVEYSHDANAQRLARYQEADSEEEEVVPRGGSVSQRGSIGS 486

  Fly   630 HETSAVIE--------------------------------------------------------- 637
            |::..|:.
Human   487 HQSVRVVHRTQSTKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPDPKLLEKVSECDKSLAVA 551

  Fly   638 ------------------EFLELLSVCHTVI---------------------------------- 650
                              :|...|::|:||:
Human   552 RHQEHLLAHLSPELSDVFDFFIALTICNTVVVTSPDQPRTKVRVRFELKSPVKTIEDFLRRFTPS 616

  Fly   651 ----------------------------------------------------------------- 650

Human   617 CLTSGCSSIGSLAANKSSHKLGSSFPSTPSSDGMLLRLEERLGQPTSAIASNGYSSQADNWASEL 681

  Fly   651 -PERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKY--VEINALGVRKRYEVLNVLEFTSS 712
             .|::....:.|.|.||||.|||..|:.:..:...|....  ||:..|| |..:|:|:.|.|.|.
Human   682 AQEQESERELRYEAESPDEAALVYAARAYNCVLVERLHDQVSVELPHLG-RLTFELLHTLGFDSV 745

  Fly   713 RKRMSLIVRTP-ENKIKLFCKGADTVIYERLAP---------QGQAFREQTLRHLEEFASDGLRT 767
            |||||:::|.| .::|.::.||||:|:.:.|.|         ..:..|.:|..:|..:|::||||
Human   746 RKRMSVVIRHPLTDEINVYTKGADSVVMDLLQPCSSVDARGRHQKKIRSKTQNYLNVYAAEGLRT 810

  Fly   768 LCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETI 832
            ||:|...:..:.|..|.|:..:|..:|:|.|..|..:|..:|.||.|||||.|||||||||||||
Human   811 LCIAKRVLSKEEYACWLQSHLEAESSLENSEELLFQSAIRLETNLHLLGATGIEDRLQDGVPETI 875

  Fly   833 ASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDA------------------ 879
            :.|..||:.||||||||||||:||.|:|:|:.|..::|.||..|.:|
Human   876 SKLRQAGLQIWVLTGDKQETAVNIAYACKLLDHDEEVITLNATSQEACAALLDQCLCYVQSRGLQ 940

  Fly   880 -----TREVIHRHYGEF---KSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCR 936
                 |:..:...:...   .:|:|.....:|||||.:|.|||..:|.:.|..|...||.|:|||
Human   941 RAPEKTKGKVSMRFSSLCPPSTSTASGRRPSLVIDGRSLAYALEKNLEDKFLFLAKQCRSVLCCR 1005

  Fly   937 VSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYL 1001
            .:|:||:.||::|.....|:|||||||||||:|||.|:||:||||.||:||..|||:::.:||||
Human  1006 STPLQKSMVVKLVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPKFRYL 1070

  Fly  1002 QRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPP 1066
            :|||::||.|.|:|::.::||.||||.....:..||..:.|:|...:.::|.:..:|:||:::||
Human  1071 ERLLILHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFFCGFSASTMIDQWYLIFFNLLFSSLPP 1135

  Fly  1067 FAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWS 1131
            ...|:.::...|..::..|.|||:.||.:.:..:.||..:.:|...|:..|.:|..||....:
Human  1136 LVTGVLDRDVPANVLLTNPQLYKSGQNMEEYRPRTFWFNMADAAFQSLVCFSIPYLAYYDSNV-- 1198

  Fly  1132 DGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIY---------- 1186
                 |....|..:.|..::|..|..|:.|.:||||..:....|::|:|...|||
Human  1199 -----DLFTWGTPIVTIALLTFLLHLGIETKTWTWLNWITCGFSVLLFFTVALIYNASCATCYPP 1258

  Fly  1187 -SHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKT----LTEAVR 1246
             :..|.|           ..||..||||...::.|:..||..:..:.:...||.|    ..:..|
Human  1259 SNPYWTM-----------QALLGDPVFYLTCLMTPVAALLPRLFFRSLQGRVFPTQLQLARQLTR 1312

  Fly  1247 ETEIRRSDISEVMNEPR-SSDSGFGYALGKLIRSSHILISHDHHPVSESSRTSNLRVENLEMEAD 1310
            ::..|.|...|...:.| ..|||..::.|:.:::|        .|:|:.|..:...|.:||...:
Human  1313 KSPRRCSAPKETFAQGRLPKDSGTEHSSGRTVKTS--------VPLSQPSWHTQQPVCSLEASGE 1369

Fly 1311 1310
Human 1370 1369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	22/61 (36%)
		ATPase-Plipid	229..1247	CDD:273734	403/1273 (32%)
		E1-E2_ATPase	286..>371	CDD:278548	37/86 (43%)
		Cation_ATPase	645..741	CDD:289987	38/198 (19%)
		HAD_like	<942..1001	CDD:304363	35/58 (60%)
		PhoLip_ATPase_C	988..1240	CDD:292829	77/262 (29%)
ATP10A	NP_077816.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		16/55 (29%)
		PhoLip_ATPase_N	49..108	CDD:292826	29/93 (31%)
		ATPase-Plipid	61..1309	CDD:273734	404/1286 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..531		6/66 (9%)
		Cation_ATPase	<697..782	CDD:289987	34/85 (40%)
		HAD_like	<1026..1057	CDD:304363	24/30 (80%)
		PhoLip_ATPase_C	1057..1302	CDD:292829	77/262 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1311..1356		13/52 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1464..1499
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830