DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and atp10d

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	XP_005156631.1	Gene:	atp10d / 571658	ZFINID:	ZDB-GENE-090313-231	Length:	1365	Species:	Danio rerio

Alignment Length:	1403	Identity:	420/1403 - (29%)
Similarity:	661/1403 - (47%)	Gaps:	322/1403 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 RVSLLAQRGLRMTASFLRRKRTEYEDDEDFTSSAGYDADD-------GERR-IINLNGPQPTKY- 229
            |:..:..|.|::.::  .|:|..|.........:..||.|       |:|| :::...|..::|
Zfish     3 RLRWVQHRCLQLIST--DRRRGWYSSPSSLPPKSSQDAQDPQVQRLSGKRRVVVSRWDPHHSEYR 65

  Fly   230 ------GNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFI 288
                  .||.|.|.||:.|||:|..||:||.|.:|.:||.:.:|..:|.|....:..|::||..:
Zfish    66 SFSKGFQNNSIRTTKYTLISFIPMNLFQQFHRAANLYFLFLVLLNWVPAVEAFQKEITMIPLAVV 130

  Fly   289 LSVSAIKEIIEDIKRHRADNEINH-----------RSIERLDSGSWCTVRWSELTVGDIIKVGIN 342
            |:|.|.|:.:||.:|:|.|.:||:           |.:||         ||:|:.|||::::..|
Zfish   131 LTVIAFKDAMEDYRRYRYDKKINNTLTHVYSGKQQRYVER---------RWAEVCVGDLVRLCCN 186

  Fly   343 TFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDL---------QRLEGR 398
            ...|||::||.||:...:|.|||||||||||||.||.:         :||         :....|
Zfish   187 EIIPADMVLLHSSDSNGVCHIETANLDGETNLKQRQVV---------RDLTQQGAEFVPENFSSR 242

  Fly   399 IECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSA 463
            ||||.||..|..|.|.:...||....|.::.:|.|...:|||..|.|||||:|.|||.|:|::..
Zfish   243 IECENPNNDLRRFRGFMEHPGKVRVGLHSENLLLRSCTVRNTETVIGIVVYAGHETKAMQNNSGP 307

  Fly   464 PLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGYNLLTFF 528
            ..|||.:::..|..:|....:|:.:|.|:.:.:..|..|..:..:.:........:..|...|..
Zfish   308 RYKRSKLERRLNLDVLWSVALLLLMCFIAAIGHGLWLSELEDPIFMIPDNTHPALAAFYMFWTMI 372

  Fly   529 ILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGT 593
            |:...||||||.|::|:|:..|..||..|:::|:...:|....|..|:.|:||.::|:|||||||
Zfish   373 IVLQVLIPISLYVSIEIVKLGQIYFIQNDLDLYNPVLDTGVQCRALNITEDLGQIQYLFSDKTGT 437

  Fly   594 LTQNVMEFKKCSIAGYVY----------------------------------------------- 611
            ||:|.|.|::|::||..|
Zfish   438 LTENRMLFRRCTVAGTEYPHHENAVSLEQYEDQACGDVDRSLTLRSRTSKKSLSCKSLSCNRSSV 502

  Fly   612 -----TAERTPEESQLVQNILGRHETSA------------------------------------- 634
                 |||   .::..|.:.|.||.|.|
Zfish   503 SLNTLTAE---SDTHSVHDTLCRHTTGAFSSTMECAVVPDPQLHMKLSTLSSPMRSPLRPDAAEI 564

  Fly   635 -VIEEFLELLSVCHTVI------------------------------------------------ 650
             :|.:|...|:||:||:
Zfish   565 SLILDFFLALTVCNTVVVSSPSQPRHVVQMPVVRTPLRSLEEMKAMFQKLSLPRFPHSPNTNTDT 629

  Fly   651 ----------------------------------------------------------------- 650

Zfish   630 PPSLTKKLFARGRSASYFPNSNPQTPVTPLESPVKLSGTPSDTPPALITPALSSSGAWGEDAEDK 694

  Fly   651 PERKENG-------------NMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRK-RY 701
            .:.|:|.             .::|.|.||||.|||:.|:.:|.....|:|:.|.:...|... ..
Zfish   695 KQAKDNAADESESDDEDEEEELLYEAESPDEAALVQAAKAYGCTLLGRSPEQVLVAVPGTGPLSI 759

  Fly   702 EVLNVLEFTSSRKRMSLIVRTP-ENKIKLFCKGADTVIYERLAPQGQ-----AFREQTLRHLEEF 760
            .:|:||.|.|:|||||::||.| ..::.::.||||.||.| ||.|.:     ...|.|.|||:::
Zfish   760 SLLHVLPFHSARKRMSVVVRHPLTGEVVVYTKGADNVIME-LAKQAEDDFSREVMELTQRHLDQY 823

  Fly   761 ASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQ 825
            |.:||||||:|...:....|:.|.:..:.|..:::|||..|.::|..:|.:|.|||||.|.||||
Zfish   824 AREGLRTLCVAKKVLGEQEYEAWMKRHEYAETSIENREELLLESAERLETDLTLLGATGIVDRLQ 888

  Fly   826 DGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHRHYGE 890
            :.|||||.:|.:|||.:||||||||||||||.::|:|:..:..|::.|.:|.:|....:.....|
Zfish   889 EEVPETIEALQEAGIKVWVLTGDKQETAINIAFACKLLRPTDHILMANCDSKEACEARLQELQLE 953

  Fly   891 FKSSSAKD-------ANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEM 948
            .:..:..|       ::..|||||.||.|||..:|:..|.||...||.|||||.:|:||::||.:
Zfish   954 VQQVTKADEPEGDCISDCVLVIDGRTLDYALQKELQGAFLDLTCCCRSVICCRSTPLQKSQVVRL 1018

  Fly   949 VTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNY 1013
            |......:|||||||||||:|||.|:||:||||.||:||..:||::|::|::|::|:||||.|.|
Zfish  1019 VRDKLEVMTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMSSDFAISRFKFLRKLILVHGHWCY 1083

  Fly  1014 ARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTA 1078
            ||::.:|||.|||||....:..|:..:.|:||..:...|.:..:|:|||::||...|:.:|..:|
Zfish  1084 ARLANMILYFFYKNVMYVNLLFWYQFFCGFSGSTMTNSWVLIFFNLLFTSVPPLVYGVLDKDVSA 1148

  Fly  1079 ETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGN 1143
            ||:::.|.|||:.||::.:....||:.|.:|...|:..|::|..||.       |.........:
Zfish  1149 ETLLKLPDLYKSGQNSQAYLPTTFWLNILDAFYQSLVCFFIPYFAYA-------GSDIGVFSFAS 1206

  Fly  1144 LVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLS 1208
            .:....::.:.|...:.:.:.||:....:..|.:.::.|:|::|.........:|..|::.:::|
Zfish  1207 PINGSALLIILLHQVIESRTLTWIHASLLIFSGLFYYAFVLLFSITCVTCNSPTNPYGIETKMMS 1271

  Fly  1209 TPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRSSDSGFGYAL 1273
            .|::|...:|..:..||..::.:...||:..             ||:.:.....|.|...:..:|
Zfish  1272 EPLYYLVCVLTTVLALLPRMLSRAFSNTICP-------------SDLVKAQKIERLSAQDYSSSL 1323

  Fly  1274 GKLIRSSHILISHDHHPVSESSRTSNLRV-ENLEMEAD 1310
            .|...:            ..:.|.|:..| :||.:.||
Zfish  1324 QKWKEN------------KATQRVSSRPVPQNLSVNAD 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	23/68 (34%)
		ATPase-Plipid	229..1247	CDD:273734	394/1274 (31%)
		E1-E2_ATPase	286..>371	CDD:278548	36/95 (38%)
		Cation_ATPase	645..741	CDD:289987	40/223 (18%)
		HAD_like	<942..1001	CDD:304363	33/58 (57%)
		PhoLip_ATPase_C	988..1240	CDD:292829	71/251 (28%)
atp10d	XP_005156631.1	PhoLip_ATPase_N	69..122	CDD:292826	21/52 (40%)
		ATPase-Plipid	71..1309	CDD:273734	395/1279 (31%)
		E1-E2_ATPase	128..>215	CDD:278548	36/95 (38%)
		Cation_ATPase	<723..799	CDD:289987	31/75 (41%)
		HAD_like	<1027..1074	CDD:304363	30/46 (65%)
		PhoLip_ATPase_C	1058..1303	CDD:292829	71/264 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830