Protein Alignment ATP8A and atp10d

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_005156631.2
• Gene: atp10d / 571658
• ZFINID: ZDB-GENE-090313-231
• Length: 1365
• Species: Danio rerio
• Alignment Length: 1403
• Identity: 418/1403 - (29%)
• Similarity: 660/1403 - (47%)
• Gaps: 322/1403 - (22%)

  Fly   174 RVSLLAQRGLRMTASFLRRKRTEYEDDEDFTSSAGYDADD-------GERRII----NLNGPQPT 227
            |:..:..|.|::.::  .|:|..|.........:..||.|       |:||::    :.:..:..
Zfish     3 RLRWVQHRCLQLIST--DRRRGWYSSPSSLPPKSSQDAQDPQVQRLSGKRRVVVSRWDTHHSEYR 65

  Fly   228 KYG----NNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFI 288
            .:.    ||.|.|.||:.|||:|..||:||.|.:|.:||.:.:|..:|.|....:..|::||..:
Zfish    66 SFSKGFQNNSIRTTKYTLISFIPMNLFQQFHRAANLYFLFLVLLNWVPAVEAFQKEITMIPLAVV 130

  Fly   289 LSVSAIKEIIEDIKRHRADNEINH-----------RSIERLDSGSWCTVRWSELTVGDIIKVGIN 342
            |:|.|.|:.:||.:|:|.|.:||:           |.:||         ||:|:.|||::::..|
Zfish   131 LTVIAFKDAMEDYRRYRYDKKINNTLTHVYSGKQQRYVER---------RWAEVCVGDLVRLCCN 186

  Fly   343 TFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDL---------QRLEGR 398
            ...|||::||.||:...:|.|||||||||||||.||.:         :||         :....|
Zfish   187 EIIPADMVLLHSSDSNGVCHIETANLDGETNLKQRQVV---------RDLTQQGCEFVPENFSSR 242

  Fly   399 IECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSA 463
            ||||.||..|..|.|.:...||....|.::.:|.|...:|||..|.|||||:|.|||.|:|::..
Zfish   243 IECENPNNDLRRFRGFMEHPGKVRVGLHSENLLLRSCTVRNTETVIGIVVYAGHETKAMQNNSGP 307

  Fly   464 PLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGYNLLTFF 528
            ..|||.:::..|..:|....:|:.:|.|:.:.:..|..|..:..:.:........:..|...|..
Zfish   308 RYKRSKLERRLNMDVLWSVALLLLMCFIAAIGHGLWLSELEDPIFMIPDNTHPALAAFYMFWTMI 372

  Fly   529 ILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGT 593
            |:...||||||.|::|:|:..|..||..|:::|:...:|....|..|:.|:||.::|:|||||||
Zfish   373 IVLQVLIPISLYVSIEIVKLGQIYFIQNDLDLYNPVLDTGVQCRALNITEDLGQIQYLFSDKTGT 437

  Fly   594 LTQNVMEFKKCSIAGYVY----------------------------------------------- 611
            ||:|.|.|::|::||..|
Zfish   438 LTENRMLFRRCTVAGTEYPHHENAVSLEQYEDQACGDVDRSLTLRSRTSKKSLSCKSLSCNRSSV 502

  Fly   612 -----TAERTPEESQLVQNILGRHETSA------------------------------------- 634
                 |||   .::..|.:.|.||.|.|
Zfish   503 SLNTLTAE---SDTHSVHDTLRRHTTGAFSSTMECAVVPDPQLHMKLSTLSSPMRSPLRPDAAEI 564

  Fly   635 -VIEEFLELLSVCHTVI------------------------------------------------ 650
             :|.:|...|:||:||:
Zfish   565 SLILDFFLALTVCNTVVVSSPSQPRHVVQMPVVRTPLRSLEEMKAMFQKLSLPRFPHSPNTNTDT 629

  Fly   651 ----------------------------------------------------------------- 650
                                                                             
Zfish   630 PPSLTKKLFARGRSASYFPNSNPQTPVTPLESPVKLSGTPSDTPPALIPPALSSSGAWGEDAEDK 694

  Fly   651 PERKENG-------------NMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRK-RY 701
            .:.|:|.             .::|.|.||||.|||:.|:.:|.....|:|:.|.:...|... ..
Zfish   695 KQAKDNAADESESDDEDEEEELLYEAESPDEAALVQAAKAYGCTLLGRSPEQVLVAVPGTGPLSI 759

  Fly   702 EVLNVLEFTSSRKRMSLIVRTP-ENKIKLFCKGADTVIYERLAPQGQ-----AFREQTLRHLEEF 760
            .:|:||.|.|:|||||::||.| ..::.::.||||.||.| ||.|.:     ...|.|.|||:::
Zfish   760 SLLHVLPFHSARKRMSVVVRHPLTGEVVVYTKGADNVIME-LAKQAEDDFSREVMELTQRHLDQY 823

  Fly   761 ASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQ 825
            |.:||||||:|...:....|:.|.:..:.|..:::|||..|.::|..:|.:|.|||||.|.||||
Zfish   824 AREGLRTLCVAKKVLGEQEYEAWMKRHEYAETSIENREELLLESAERLETDLTLLGATGIVDRLQ 888

  Fly   826 DGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHRHYGE 890
            :.|||||.:|.:|||.:||||||||||||||.::|:|:..:..|::.|.:|.:|....:.....|
Zfish   889 EEVPETIEALQEAGIKVWVLTGDKQETAINIAFACKLLRPTDHILMANCDSKEACEARLQELQLE 953

  Fly   891 FKSSSAKD-------ANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEM 948
            .:..:..|       ::..|||||.||.|||..:|:..|.||...||.|||||.:|:||::||.:
Zfish   954 VQQVTKADEPEGDCISDCVLVIDGRTLDYALQKELQGAFLDLTCCCRSVICCRSTPLQKSQVVRL 1018

  Fly   949 VTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNY 1013
            |......:|||||||||||:|||.|:||:||||.||:||..:||::|::|::|::|:||||.|.|
Zfish  1019 VRDKLEVMTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMSSDFAISRFKFLRKLILVHGHWCY 1083

  Fly  1014 ARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTA 1078
            ||::.:|||.|||||....:..|:..:.|:||..:...|.:..:|:|||::||...|:.:|..:|
Zfish  1084 ARLANMILYFFYKNVMYVNLLFWYQFFCGFSGSTMTNSWVLIFFNLLFTSVPPLVYGVLDKDVSA 1148

  Fly  1079 ETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGN 1143
            ||:::.|.|||:.||::.:....||:.|.:|...|:..|::|..||.       |.........:
Zfish  1149 ETLLKLPDLYKSGQNSQAYLPTTFWLNILDAFYQSLVCFFIPYFAYA-------GSDIGVFSFAS 1206

  Fly  1144 LVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLS 1208
            .:....::.:.|...:.:.:.||:....:..|.:.::.|:|::|.........:|..|::.:::|
Zfish  1207 PINGSALLIILLHQVIESRTLTWIHASLLIFSGLFYYAFVLLFSITCVTCNSPTNPYGIETKMMS 1271

  Fly  1209 TPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRSSDSGFGYAL 1273
            .|::|...:|..:..||..::.:...||:..             ||:.:.....|.|...:..:|
Zfish  1272 EPLYYLVCVLTTVLALLPRMLSRAFSNTICP-------------SDLVKAQKIERLSAQDYSSSL 1323

  Fly  1274 GKLIRSSHILISHDHHPVSESSRTSNLRV-ENLEMEAD 1310
            .|...:            ..:.|.|:..| :||.:.||
Zfish  1324 QKWKEN------------KATQRVSSRPVPQNLSVNAD 1349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	372/1138 (33%)
atp10d	XP_005156631.2	None