Protein Alignment ATP8A and atp9b

DIOPT Version :9

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_005170114.1
• Gene: atp9b / 568160
• ZFINID: ZDB-GENE-060503-583
• Length: 1136
• Species: Danio rerio
• Alignment Length: 1087
• Identity: 316/1087 - (29%)
• Similarity: 517/1087 - (47%)
• Gaps: 153/1087 - (14%)

  Fly   217 RIINLNGPQ--PTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRY 279
            |.:.|..|:  ..||..|.|...||:.::|:|..|::||:.:.|.:||::|..|.:|.:.....|
Zfish   103 RTVWLGHPEKCEEKYPKNAIKNQKYNIVTFVPGVLYQQFKFFLNLYFLVVACSQFVPSLKIGYLY 167

  Fly   280 TTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTF 344
            |...||.|:|:|:.::|.:::::|.|.|.|:|.:...:|.......|:.|::.|||:|.|..|..
Zfish   168 TYWAPLGFVLAVTMVREAVDEVRRCRRDKEMNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQR 232

  Fly   345 FPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLY 409
            .|||:|.|.:||....|||.|..|||||:.|:|..:..|..|....||..:...:..:.|...::
Zfish   233 IPADMIFLRTSEKTGSCFIRTDQLDGETDWKLRIGVACTQRLPALGDLFSISAYVYVQKPQLDIH 297

  Fly   410 EFNG-VLRETGKPPAALGNDQVLQRGAILRNTAW---------VFGIVVYSGQETKLMKNSTSAP 464
            .|.| ..||...||        :.....:.||.|         |.|:|:|:|:|.:.:.|::.:.
Zfish   298 SFEGNFTREDCDPP--------IHESLSIENTLWASTVVASGTVIGVVIYTGKEMRSVMNTSQSK 354

  Fly   465 LKRSTVDKLTN--TQILMLFMILISLCIIS--GLCNLFWTREHSETDWYLGLTDFKTKSLGYNLL 525
            .|...:|...|  |:.|.|..:::|:.:::  |...          .|:            .||.
Zfish   355 NKVGLLDLELNRLTKALFLAQVVLSVVMVALQGFLG----------PWF------------RNLF 397

  Fly   526 TFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTP-AMARTSNLNEELGMVKYIFSD 589
            .|.:|::.:|||||:|.|::.:......|..|       .|.| .:.|||.:.||||.:.|:.:|
Zfish   398 RFVVLFSYIIPISLRVNLDMGKSAYGWMIMKD-------ENIPGTVVRTSTIPEELGRLVYLLTD 455

  Fly   590 KTGTLTQNVMEFKKCSIAGYVYTAERTPE-ESQLVQNILG------------------------- 628
            ||||||||.|.||:..:....|..:...| :|.::|:...
Zfish   456 KTGTLTQNEMVFKRLHLGTVSYGTDTMDEIQSHIIQSYAQVSSAQSNGSSASSTPSRKPQPPAPK 520

  Fly   629 -RHETSAVIEEFLELLSVCHTVIP--ERKENG-----------------NMIYHAASPDERALVE 673
             |...|:.|.|.::.:::||.|.|  |.:.||                 |..|.|:||||.|||.
Zfish   521 VRKSVSSRIHEAVKAIALCHNVTPVYESRVNGANAEPESTEADQDFSDDNRTYQASSPDEVALVR 585

  Fly   674 GAQKFGYIFDTRTPKYVEINA-LGVRKRYEVLNVLEFTSSRKRMSLIVR-TPENKIKLFCKGADT 736
            ..:..|.....|....:::.. .|....|.:|.:..|||..|||.:||| .....|..:.||||.
Zfish   586 WTESVGLTLVNRDLTSLQLKTPAGQILTYYILQIFPFTSESKRMGIIVREEATGDITFYMKGADV 650

  Fly   737 VIYERLAPQGQAFREQTLRHLEE----FASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNR 797
            .:         |...|....|||    .|.:|||||.:|...:..:.||::...:::|.:::.:|
Zfish   651 AM---------ASIVQYNDWLEEECGNMAREGLRTLVVAKKSLTEEQYQDFENRYNQAKLSIHDR 706

  Fly   798 ESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRL 862
            ..|:......:|..:.||..|.:||:||..|..|:..|.:|||.||:|||||.|||..|..|..|
Zfish   707 NLKVAAVVESLEREMELLCLTGVEDQLQADVRPTLELLRNAGIKIWMLTGDKLETATCIAKSSHL 771

  Fly   863 ISHSMDIIILNEESLDATREVIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCI 927
            :|.:.||.:....|   .|...|.....|:    :..:.||||.|.:|:..|.. ..::|.:|..
Zfish   772 VSRNQDIHVFKPVS---NRGEAHLELNAFR----RKHDCALVISGDSLEVCLRY-YEHEFVELAC 828

  Fly   928 LCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASD 992
            .|..|:|||.||.|||::|.::.|.|...|.|||||.|||:|||.|:.||||.|.||.||:.|:|
Zfish   829 QCPAVVCCRCSPTQKAQIVRLLQQHTANRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQASLAAD 893

  Fly   993 YSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLY 1057
            :||.||:::.|||:|||..:|.|.:.|..:..::.:.:..::..|:....::...|::.:.:..|
Zfish   894 FSITQFKHIGRLLMVHGRNSYKRSAALGQFVMHRGMIISTMQAVFSSIFYFASVPLYQGFLMVGY 958

  Fly  1058 NVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLA 1122
            ..::|..|.|:: :.::....|..:.||.|||.....:..:.|.|.||:..::.....|.:..|.
Zfish   959 ATIYTMFPVFSL-VLDQDVKPEMALLYPELYKDLTKGRSLSFKTFLIWVLISIYQGGILMYGALV 1022

  Fly  1123 AYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYS 1187
            .:.:|          ::.:..:.:|.:|:|..|...|...:|.||..:|...|:..:...|
Zfish  1023 LFDQE----------FVHVVAISFTALILTELLMVALTIRTWHWLMVVAQLISLACYLASL---- 1073

  Fly  1188 HVWPMFKFASNFRG---------MDIQLLSTPVFYFCLMLVPITTLL 1225
                  .|.:.:.|         :|:..::|.||.:.:.::.:.:.|
Zfish  1074 ------AFLNEYFGIGRVTLGAFLDLSFITTRVFLWKVCVITLVSCL 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	19/63 (30%)
		ATPase-Plipid	229..1247	CDD:273734	312/1073 (29%)
		E1-E2_ATPase	286..>371	CDD:278548	31/84 (37%)
		Cation_ATPase	645..741	CDD:289987	36/116 (31%)
		HAD_like	<942..1001	CDD:304363	33/58 (57%)
		PhoLip_ATPase_C	988..1240	CDD:292829	52/247 (21%)
atp9b	XP_005170114.1	PhoLip_ATPase_N	104..168	CDD:292826	19/63 (30%)
		ATPase-Plipid	117..1134	CDD:273734	312/1073 (29%)
		E1-E2_ATPase	173..413	CDD:278548	76/269 (28%)
		Cation_ATPase	567..649	CDD:289987	27/81 (33%)
		HAD_like	730..880	CDD:119389	67/157 (43%)
		PhoLip_ATPase_C	889..1128	CDD:292829	52/247 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930