DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and atp10b

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	XP_017214606.1	Gene:	atp10b / 563932	ZFINID:	ZDB-GENE-130530-796	Length:	1294	Species:	Danio rerio

Alignment Length:	1284	Identity:	412/1284 - (32%)
Similarity:	620/1284 - (48%)	Gaps:	272/1284 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 DADDGERRIINLNGP--------QPTK-YGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIA 265
            |.|...|:::: |.|        ||.: |..|.|.|.||...||||..|||||.|.:|.:|:.:|
Zfish    19 DQDRPIRKVVS-NLPFEDLRKREQPNRQYEGNAIKTNKYRLWSFLPMNLFEQFHRLANIYFVGLA 82

  Fly   266 ILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTV--RW 328
            ||..||.|:.......|:|:..||:::|:|:..||.:|::.|.::|:...........|.|  ||
Zfish    83 ILNFIPVVNAFQPEVALIPICIILALTAVKDGWEDFRRYQTDQQLNNMPCFIFRRRLMCFVERRW 147

  Fly   329 SELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQ 393
            .::.|||.:||..|...|||::||.:|:|..:|.:||||||||||||.|:.:|..:.|.|....|
Zfish   148 KDVRVGDFVKVLSNEIIPADILLLHTSDPNGVCHMETANLDGETNLKQRKVVPGFSTLGEPFQPQ 212

  Fly   394 RLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMK 458
            ..:..:.||.||.:|..|.|.:....|..:..|.|.:|.||..:|||....|||||:|.|||.|.
Zfish   213 TFDSTVVCENPNNNLNLFKGFIERPDKRRSGFGIDSLLLRGCTVRNTDDAAGIVVYAGHETKSML 277

  Fly   459 NSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDWYL-----------GL 512
            |:.....|||.:::..||.:|...::|..:|:|..|.:..|....|....|:           .|
Zfish   278 NNNGPRYKRSKIERKMNTDVLFCVLLLFFMCLIGALGHAIWLETFSTMPSYIVPDSNGNYISSAL 342

  Fly   513 TDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLN 577
            ..|      |...|..||...:||:||.|::|||:..|..||..|.|:|.:|.::....|..|:.
Zfish   343 AGF------YMFFTMIILLQVMIPVSLYVSIELVKMGQIFFITQDAELYDQELDSRVQCRALNIT 401

  Fly   578 EELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERTP-----------EESQL--------- 622
            |:||.::|:|||||||||:|.|.||:|:|.|..|..|...           ||.::
Zfish   402 EDLGQIQYVFSDKTGTLTENKMVFKRCTIMGTEYCHEENAARLAVINGGGNEEEEVTIYQKTKLP 466

  Fly   623 ------------------------------------------------------------VQNIL 627
                                                                        |.:.:
Zfish   467 PLFPLEELQDDHTGHKNHANTQVAAASRRRSKVAAGAQSDMAFSSPLETVVVPDRKLMLEVDHQM 531

  Fly   628 GRHETSAVIEEFLELLSVCHTVI------------------------------------------ 650
            ...:|...::.|| .|::|:||:
Zfish   532 ASIQTGPYLDFFL-ALAICNTVVVSTLTAQRQRVKGRRNSSYSGSSSHNMGQWFKISSLQKFFSS 595

  Fly   651 ---------------------------------PERK-------------ENGNMIYHAASPDER 669
                                             |.:|             .:..:.|.|.||||.
Zfish   596 MRFKRNRETMADPFAIDEDEPDTFHISSVSDSRPGQKVISSEGKDKRSLSRSEEVCYEAHSPDEA 660

  Fly   670 ALVEGAQKFGYIFDTRTPKYVEINALG-VRKRYEVLNVLEFTSSRKRMSLIVRTPE-NKIKLFCK 732
            ||:..|:.:|:....|||:||.:.... ...::|||:||.|.|:|:|||:|||.|. |:|.::.|
Zfish   661 ALIHAAKAYGFTMVERTPRYVTVKLPNETLLKFEVLDVLTFDSTRRRMSIIVRHPHTNEIIMYTK 725

  Fly   733 GADTVIYERLAPQGQAFREQ---------TLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFD 788
            |||:.:.|:|   |..|..:         |.:.|:.:|.|||||||.|...|....::.|..:..
Zfish   726 GADSAVMEKL---GNVFSVESAAKRIAVRTQKDLDMYARDGLRTLCFAKKVISEQEFKAWFTSRQ 787

  Fly   789 KASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETA 853
            :|..|:..:|.:|.:.||.|||||.|||||.||||||:.|||||.:|..||:.:|||||||.|||
Zfish   788 EALSAIDEKEERLMETANDIENNLTLLGATGIEDRLQENVPETIQALRRAGMQVWVLTGDKPETA 852

  Fly   854 INIGYSCRLISHSMDIII---LNEES-----LDATREVIHRHYG------EFKSSSA------KD 898
            :||.|||:|:.|. |::.   .|::|     |:.|...:.|.:|      :|:..::      .:
Zfish   853 VNIAYSCKLLDHE-DLVFTFTTNKKSVCKMRLEDTLSEVRRTWGGLGLDPQFRGYNSTFTGPLME 916

  Fly   899 ANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDG 963
            .::.|||||.||..|||.||...|.:||..||.|:||||:|:||:.||:::.|....:|||:|||
Zfish   917 PSIGLVIDGPTLNMALSEDLVEQFVELCKHCRAVLCCRVTPLQKSSVVKVIRQKLRVMTLAVGDG 981

  Fly   964 ANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNV 1028
            ||||.|||.|:||||:||.||:||..|||::|.:|::|||||||||.|.|:|::.:::|.|||||
Zfish   982 ANDVNMIQAADVGIGVSGQEGMQAVMASDFAITRFKHLQRLLLVHGHWCYSRLANMVIYFFYKNV 1046

  Fly  1029 CLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQN 1093
            ....:..|:..:.|:||..:.:.|.:..:|:.||:.||...|:.:|..:..|::..|.||:..|:
Zfish  1047 AYVNLLFWYQFFCGFSGTAMIDYWLMIFFNLFFTSAPPIMFGIMDKEVSDSTLLSLPELYRRGQH 1111

  Fly  1094 AKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAG 1158
            ::.:....|||.|.:|...|:..|::|...|....|       .....|..:.|..:.|:.|...
Zfish  1112 SEGYRRSTFWIAILDAFYQSLVCFFIPYWTYNDSDI-------GIFSFGTPMNTVSLFTIILHLA 1169

  Fly  1159 LITNSWTWLTHLAIWGSIVLWFGFLLIYSHV-----------WPMFKFASNFRGMDIQLLSTPVF 1212
            :...|||.:..:.:.||::::|...|.||.:           |.|.|           .::.|:|
Zfish  1170 IEIKSWTVVHWVIMVGSVLVYFILTLAYSAICISCNPPSDPYWIMHK-----------QMADPMF 1223

  Fly  1213 YFCLMLVPITTLLIDVICKLVHNTV----------FKTLTEAVRETEIR 1251
            |...:|..:..||.....:::..|:          .:.|..:.||.:||
Zfish  1224 YLVCVLTTVVALLPRYTLRVLKGTLAPSLHLRARQLERLPSSCREQQIR 1272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	28/70 (40%)
		ATPase-Plipid	229..1247	CDD:273734	401/1250 (32%)
		E1-E2_ATPase	286..>371	CDD:278548	33/86 (38%)
		Cation_ATPase	645..741	CDD:289987	41/185 (22%)
		HAD_like	<942..1001	CDD:304363	33/58 (57%)
		PhoLip_ATPase_C	988..1240	CDD:292829	73/272 (27%)
atp10b	XP_017214606.1	PhoLip_ATPase_N	38..95	CDD:292826	26/56 (46%)
		ATPase-Plipid	46..1258	CDD:273734	400/1240 (32%)
		Cation_ATPase	<656..738	CDD:289987	37/84 (44%)
		R3H	793..856	CDD:294210	39/62 (63%)
		HAD_like	<960..1006	CDD:304363	27/45 (60%)
		PhoLip_ATPase_C	1006..1251	CDD:292829	73/262 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830