Protein Alignment ATP8A and atp8b5b

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_691903.2
• Gene: atp8b5b / 563450
• ZFINID: ZDB-GENE-120502-1
• Length: 1189
• Species: Danio rerio
• Alignment Length: 1223
• Identity: 486/1223 - (39%)
• Similarity: 699/1223 - (57%)
• Gaps: 153/1223 - (12%)

  Fly   176 SLLAQRGLRMTASFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYS 240
            |||:..|:.:....:..:|....:|.:|..|                    .||.||.|.|:||:
Zfish     3 SLLSACGINVKKKKVEEERRLRANDREFNLS--------------------FKYANNAIKTSKYN 47

  Fly   241 FISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHR 305
            ..:|||..|||||:|.:|.:|:.:.|||.||::|....:||:|||:.:||::..|::.:||.||:
Zfish    48 VFTFLPLNLFEQFQRLANAYFVFLLILQLIPQISSLSWFTTVVPLLLVLSITLAKDLSDDITRHK 112

  Fly   306 ADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDG 370
            .|.::|:|.:|.|..|...|.||..:.||||:|:..|.|..|||:|||||||..:.:||||.|||
Zfish   113 NDKQVNNRKVEVLIDGELKTERWMNVQVGDIVKLENNEFVTADLLLLSSSEPLNLIYIETAELDG 177

  Fly   371 ETNLKIRQALPATAELLETKDLQRL---EGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQ 432
            |||||::|||..|.||  ..|:|||   :|.:.||.||..|.:|.|.| ..|....||.|:::|.
Zfish   178 ETNLKVKQALTLTGEL--CNDIQRLAAFKGEVRCEPPNNRLDKFTGTL-VVGGETFALDNERILL 239

  Fly   433 RGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNL 497
            ||..||||.|.||:|::.|.:||||:||..:..||:::|.|.|..:|.:|..|..:|.|..:.|.
Zfish   240 RGCTLRNTEWCFGLVLFGGPDTKLMQNSGKSIFKRTSIDHLMNVLVLFIFGFLAFMCTILSIGNA 304

  Fly   498 FWTREHSETDWYLGLTDFKTKSLGYN-----LLTFF---ILYNNLIPISLQVTLELVRFLQAIFI 554
            .|  |:.|.:.::   .|..::.|.|     .|||:   |:.|.::||||.|::|::|...:.||
Zfish   305 IW--EYQEGNSFI---VFLPRADGANASLSAFLTFWSYVIILNTVVPISLYVSVEILRLGNSYFI 364

  Fly   555 NYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY-------- 611
            ::|.:|||.:|:|||.|||:.||||||.:||||||||||||||:|.|.:|||.|..|
Zfish   365 DWDRKMYHVKSDTPAQARTTTLNEELGQIKYIFSDKTGTLTQNIMTFNRCSINGKSYGEVVDFAG 429

  Fly   612 ----TAERTPE----------------ESQLVQNI-LGRHETSAVIEEFLELLSVCHTVIPERKE 655
                ..|:|.:                :.:||:.: ||..|..|    |..||::||||:||.|.
Zfish   430 QRVEVTEKTEKVDFSWNLLADPKFFFHDHKLVEAVKLGSPEVHA----FFRLLALCHTVMPEEKT 490

  Fly   656 NGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIV 720
            .|::.|.|.||||.|||..|:.||::|..|||:.:.:..:|:...||:|.||:|.:.|||||:||
Zfish   491 QGDLFYQAQSPDEGALVTAARNFGFVFRARTPETISVVEMGIETTYELLAVLDFNNVRKRMSVIV 555

  Fly   721 RTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQ 785
            |.||.|:.|:||||||:|||||.|......|.|..||.|:|.:|||||.||..|:..|.:.||.:
Zfish   556 RNPEGKLMLYCKGADTIIYERLHPSCSKVMEVTTEHLNEYAGEGLRTLALAYKDLDEDKFAEWRR 620

  Fly   786 TFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQ 850
            ...:||:||::||.||:.....||.:|.|:||:|:||:||||||:||..|..|.|.|||||||||
Zfish   621 RHHEASIALEDREEKLDAIYEEIEKDLILIGASAVEDKLQDGVPQTIEQLAKADIKIWVLTGDKQ 685

  Fly   851 ETAINIGYSCRLISHSM-DIIILNEESLDATREVI-------------------HRHYGEFKSSS 895
            |||.||||||.::...| :|.|:...:.:..||.:                   .|..|: ||..
Zfish   686 ETAENIGYSCNMLREEMTEIFIVAANTAEEVREELVNARKKMSPESGDEPPMEKSRFLGK-KSQV 749

  Fly   896 AKDANV----ALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAV 956
            .:|..|    .|||:|.:|.:||..|::.:......:|:.||||||:|:|||:|||:|.:...||
Zfish   750 VEDEKVDGEYGLVINGHSLAFALQKDMQVELLRTACMCQTVICCRVTPLQKAQVVELVKKHKKAV 814

  Fly   957 TLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLIL 1021
            |||||||||||:||:.|::|:||||.||:||..:||:|.||||||||||||||.|:|.|:...:.
Zfish   815 TLAIGDGANDVSMIKTAHIGVGISGQEGMQAVLSSDFSFAQFRYLQRLLLVHGRWSYLRMCTFLR 879

  Fly  1022 YSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPM 1086
            |.||||.....:..|:|.:.|:|.|.:::.|.|.|||:::||:|...:.||::........:||.
Zfish   880 YFFYKNFTFTFVHFWYAFFCGFSAQTVYDEWYITLYNLVYTALPVLGISLFDQDVNDRWSFQYPQ 944

  Fly  1087 LYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGK-TSDYLLMGNLVYTYVI 1150
            ||...|..:.|:...|...:.::...|:.||::|.||.. :.:..||| .:||.....|..|.::
Zfish   945 LYAPGQMNQYFSKMAFAKILLHSCYSSLILFFVPWAAMW-DTVRDDGKDIADYQSFALLAQTCLL 1008

  Fly  1151 VTVCLKAGLITNSWTWLTHLAIWGSIVLWF---------GFLLIYSHVWPMFKFASNFRGMDIQL 1206
            :.|.::.||.|..||.:.|..:|||:.::|         |..||::..:|....|.|       .
Zfish  1009 IAVSVQLGLDTYYWTAVNHFFLWGSLSVYFAVTFTMYSNGMYLIFTSSFPFIGTARN-------S 1066

  Fly  1207 LSTPVFYFCLMLVPITTLL--IDVICKLVHNTVFK-TLTEAVRETEIRRSDISEVMNEP------ 1262
            |:.|..:..:.|   ||:|  :.|:.|......|| |:.:.||.      .:.:...||
Zfish  1067 LNQPNVWLTIFL---TTILCVLPVVAKRFLFIQFKPTINDKVRH------KVKQAKAEPPPPPQR 1122

  Fly  1263 ----RSSDSGFGYAL------------GKLIR----SSHILISHDHHPVSESS 1295
                |.|....|||.            |:.:|    |...|.|.:..||::|:
Zfish  1123 FPRRRISTRRSGYAFSHARGYGDLVTSGRFLRIPVKSRPALFSKNESPVADST 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	421/952 (44%)
atp8b5b	XP_691903.2	P-type_ATPase_APLT_Dnf-like	38..978	CDD:319770	421/952 (44%)