Protein Alignment ATP8A and atp8b4

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_687715.4
• Gene: atp8b4 / 559291
• ZFINID: ZDB-GENE-121116-7
• Length: 1214
• Species: Danio rerio
• Alignment Length: 1213
• Identity: 479/1213 - (39%)
• Similarity: 698/1213 - (57%)
• Gaps: 122/1213 - (10%)

  Fly   192 RKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRY 256
            :|....|::....::   |.|..||          ..|.:|||.||||:..:|||..|||||:|:
Zfish    24 KKDVHIEEERHVRAN---DRDYNER----------FSYADNRIKTAKYNVFTFLPINLFEQFQRF 75

  Fly   257 SNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSG 321
            :|.:||::.|||.|||:|....:||:|||:.:|:::|:|:..:|..||::|.::|.|..:.|..|
Zfish    76 ANAYFLVLLILQLIPEISSLSWFTTIVPLVLVLAITAVKDATDDYFRHKSDQQVNTRQSQVLIKG 140

  Fly   322 SWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAEL 386
            .....:|..:.|||:||:..|.|..|||:|||||||..:|:||||.||||||||:||||..|::|
Zfish   141 KLQNEKWMNVRVGDVIKLENNQFVAADLLLLSSSEPYGLCYIETAELDGETNLKVRQALTVTSDL 205

  Fly   387 LETKDLQRL---EGRIECELPNRHLYEFNGVLR-ETGKPPAALGNDQVLQRGAILRNTAWVFGIV 447
            .:  |:.:|   .|.:.||.||..|.:|.|.|. :..|.|  |.|:::|.||.:||||.|.||:|
Zfish   206 GD--DVAKLADFNGEVICEPPNNKLDKFIGTLYWKDNKYP--LDNEKMLLRGCVLRNTEWCFGLV 266

  Fly   448 VYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDW-YLG 511
            :::|.:||||:|......||:::|||.||.:|.:|..||.:.||..:.|..|.:......| ||.
Zfish   267 IFAGLQTKLMQNCGRTKFKRTSIDKLMNTLVLWIFGFLICMGIILAIGNTIWEQSVGSDFWAYLQ 331

  Fly   512 LTDFKTKSLGYNLLTFF---ILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMART 573
            ..:....::....|||:   |:.|.::||||.|::|::|...:.|||:|..||:...:|||.|||
Zfish   332 WKELTVNAVFSGFLTFWSYIIILNTVVPISLYVSVEVLRLGHSYFINWDRRMYYSRKDTPAEART 396

  Fly   574 SNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY------------TAERTP----EESQL 622
            :.||||||.|::||||||||||||:|.|.||||.|..|            ..|:||    ..:.|
Zfish   397 TTLNEELGQVEFIFSDKTGTLTQNIMVFNKCSINGKTYGDVFDEFGHKVDITEKTPCVDFSFNPL 461

  Fly   623 VQNILGRHETSAV---------IEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKF 678
            :......|::|.|         ::||..||::||||:||.:..|.::|.|.||||.|||..|:.|
Zfish   462 MDRKFRFHDSSLVEAIKLEEPLVQEFFRLLALCHTVMPEERNEGELVYQAQSPDEGALVTAARNF 526

  Fly   679 GYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLA 743
            |::|.:|||:.:.:..:|....|::|.:|:|.:.|||||:|||.|:.::||:.|||||::::||.
Zfish   527 GFVFRSRTPETITLYEMGQAVTYQLLAILDFNNVRKRMSVIVRNPKGQLKLYSKGADTILFDRLD 591

  Fly   744 PQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLI 808
            |..:.....|..||.|||.:|||||.||..|:..||:.||::....||.||.|||.||......|
Zfish   592 PSNEELMFTTSEHLNEFAGEGLRTLALAYKDLDEDVFDEWTKKLLFASTALDNREEKLGALYEEI 656

  Fly   809 ENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMD--III 871
            |..:.|||||||||:||:|||||||.|..|.|.||||||||.|||:||||||.::...|:  .||
Zfish   657 EQGMMLLGATAIEDKLQEGVPETIACLTLANIKIWVLTGDKLETAMNIGYSCNMLRDDMNEVFII 721

  Fly   872 LNEESLDATREV---IHRHYGEFKS--SSAKD------------------ANVALVIDGTTLKYA 913
            .....|:..:|:   ..|..|..|.  ||..|                  |..||:|:|.:|.:|
Zfish   722 SGHTMLEVQQELRTAKERIMGPSKDKFSSGLDMEKTELYSVDSVFEETIIAEYALIINGHSLAHA 786

  Fly   914 LSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIG 978
            |..:|.....|:..||:.||||||:|:|||.|||::.:...|||||||||||||:||:.|::|:|
Zfish   787 LEAELEQILVDVACLCKSVICCRVTPLQKALVVELIKRHKRAVTLAIGDGANDVSMIKTAHIGVG 851

  Fly   979 ISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGW 1043
            |||.||:||..|||||.||||||||||||||.|:|.|:...:.|.||||....::..|:....|:
Zfish   852 ISGQEGMQAVLASDYSFAQFRYLQRLLLVHGRWSYHRMCNFLCYFFYKNFAFTLVHFWYGFLCGF 916

  Fly  1044 SGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFN 1108
            |.|.::::|.|.|:|:::|::|..|||||::....:..:|||.||:..|..:|||.:.|:.....
Zfish   917 SAQTVYDQWFITLFNIVYTSLPVLAMGLFDQDVNEQYSLRYPNLYRPGQLNQLFNKRKFFTCTLQ 981

  Fly  1109 ALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIW 1173
            .:..|..||::|..|:...|.....:.||.......:.|.:::.|.::.||.||.||.:.|..||
Zfish   982 GVYTSFILFFIPYGAFMPAVRDDGAQISDQQAFAVTIATSLVIVVSVQIGLDTNYWTAVNHFFIW 1046

  Fly  1174 GSIVLWF---------GFLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVI 1229
            ||:.::|         |...|:.:.:|....|.|       .|:..:.:..::|..:..::..:.
Zfish  1047 GSLAVYFAILFAMNSNGIFTIFPNQFPFIGSARN-------SLNQKIVWLVILLNTVVCIMPMLA 1104

  Fly  1230 CKLVHNTVFKTLTEAVR----ETEIRRSDISEVMNEPRSSDSGFGYAL------GKLIRSSHIL- 1283
            .:.:...::.|.|:.||    .|..:|.....:....|:|.....||.      |:||.|...:
Zfish  1105 VRFIKTDLYPTHTDKVRLLQQATRRQRPQEQNLRRVRRTSSRRSAYAFSHQQGYGELITSGKNMK 1169

  Fly  1284 ---ISHDHHPVSESSR--------TSNLR---------VENLE 1306
               .|...:|:|..||        ::|.|         ||:||
Zfish  1170 VPTSSTSTYPLSSPSRAPGEKGTTSANSRPSEHKQEVTVEDLE 1212

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	421/946 (45%)
atp8b4	XP_687715.4	P-type_ATPase_APLT_Dnf-like	50..993	CDD:319770	421/946 (45%)