DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and atp8b4

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	XP_687715.4	Gene:	atp8b4 / 559291	ZFINID:	ZDB-GENE-121116-7	Length:	1214	Species:	Danio rerio

Alignment Length:	1210	Identity:	477/1210 - (39%)
Similarity:	696/1210 - (57%)	Gaps:	113/1210 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 RKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRY 256
            :|....|::....::   |.|..||          ..|.:|||.||||:..:|||..|||||:|:
Zfish    24 KKDVHIEEERHVRAN---DRDYNER----------FSYADNRIKTAKYNVFTFLPINLFEQFQRF 75

  Fly   257 SNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSG 321
            :|.:||::.|||.|||:|....:||:|||:.:|:::|:|:..:|..||::|.::|.|..:.|..|
Zfish    76 ANAYFLVLLILQLIPEISSLSWFTTIVPLVLVLAITAVKDATDDYFRHKSDQQVNTRQSQVLIKG 140

  Fly   322 SWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAEL 386
            .....:|..:.|||:||:..|.|..|||:|||||||..:|:||||.||||||||:||||..|::|
Zfish   141 KLQNEKWMNVRVGDVIKLENNQFVAADLLLLSSSEPYGLCYIETAELDGETNLKVRQALTVTSDL 205

  Fly   387 LETKDLQRL---EGRIECELPNRHLYEFNGVLR-ETGKPPAALGNDQVLQRGAILRNTAWVFGIV 447
            .:  |:.:|   .|.:.||.||..|.:|.|.|. :..|.|  |.|:::|.||.:||||.|.||:|
Zfish   206 GD--DVAKLADFNGEVICEPPNNKLDKFIGTLYWKDNKYP--LDNEKMLLRGCVLRNTEWCFGLV 266

  Fly   448 VYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDW-YLG 511
            :::|.:||||:|......||:::|||.||.:|.:|..||.:.||..:.|..|.:......| ||.
Zfish   267 IFAGLQTKLMQNCGRTKFKRTSIDKLMNTLVLWIFGFLICMGIILAIGNTIWEQSVGSDFWAYLQ 331

  Fly   512 LTDFKTKSLGYNLLTFF---ILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMART 573
            ..:....::....|||:   |:.|.::||||.|::|::|...:.|||:|..||:...:|||.|||
Zfish   332 WKELTVNAVFSGFLTFWSYIIILNTVVPISLYVSVEVLRLGHSYFINWDRRMYYSRKDTPAEART 396

  Fly   574 SNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY------------TAERTP----EESQL 622
            :.||||||.|::||||||||||||:|.|.||||.|..|            ..|:||    ..:.|
Zfish   397 TTLNEELGQVEFIFSDKTGTLTQNIMVFNKCSINGKTYGDVFDEFGHKVDITEKTPCVDFSFNPL 461

  Fly   623 VQNILGRHETSAV---------IEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKF 678
            :......|::|.|         ::||..||::||||:||.:..|.::|.|.||||.|||..|:.|
Zfish   462 MDRKFRFHDSSLVEAIKLEEPLVQEFFRLLALCHTVMPEERNEGELVYQAQSPDEGALVTAARNF 526

  Fly   679 GYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLA 743
            |::|.:|||:.:.:..:|....|::|.:|:|.:.|||||:|||.|:.::||:.|||||::::||.
Zfish   527 GFVFRSRTPETITLYEMGQAVTYQLLAILDFNNVRKRMSVIVRNPKGQLKLYSKGADTILFDRLD 591

  Fly   744 PQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLI 808
            |..:.....|..||.|||.:|||||.||..|:..||:.||::....||.||.|||.||......|
Zfish   592 PSNEELMFTTSEHLNEFAGEGLRTLALAYKDLDEDVFDEWTKKLLFASTALDNREEKLGALYEEI 656

  Fly   809 ENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMD--III 871
            |..:.|||||||||:||:|||||||.|..|.|.||||||||.|||:||||||.::...|:  .||
Zfish   657 EQGMMLLGATAIEDKLQEGVPETIACLTLANIKIWVLTGDKLETAMNIGYSCNMLRDDMNEVFII 721

  Fly   872 LNEESLDATREV---IHRHYGEFKS--SSAKD------------------ANVALVIDGTTLKYA 913
            .....|:..:|:   ..|..|..|.  ||..|                  |..||:|:|.:|.:|
Zfish   722 SGHTMLEVQQELRTAKERIMGPSKDKFSSGLDMEKTELYSVDSVFEETIIAEYALIINGHSLAHA 786

  Fly   914 LSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIG 978
            |..:|.....|:..||:.||||||:|:|||.|||::.:...|||||||||||||:||:.|::|:|
Zfish   787 LEAELEQILVDVACLCKSVICCRVTPLQKALVVELIKRHKRAVTLAIGDGANDVSMIKTAHIGVG 851

  Fly   979 ISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGW 1043
            |||.||:||..|||||.||||||||||||||.|:|.|:...:.|.||||....::..|:....|:
Zfish   852 ISGQEGMQAVLASDYSFAQFRYLQRLLLVHGRWSYHRMCNFLCYFFYKNFAFTLVHFWYGFLCGF 916

  Fly  1044 SGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFN 1108
            |.|.::::|.|.|:|:::|::|..|||||::....:..:|||.||:..|..:|||.:.|:.....
Zfish   917 SAQTVYDQWFITLFNIVYTSLPVLAMGLFDQDVNEQYSLRYPNLYRPGQLNQLFNKRKFFTCTLQ 981

  Fly  1109 ALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIW 1173
            .:..|..||::|..|:...|.....:.||.......:.|.:::.|.::.||.||.||.:.|..||
Zfish   982 GVYTSFILFFIPYGAFMPAVRDDGAQISDQQAFAVTIATSLVIVVSVQIGLDTNYWTAVNHFFIW 1046

  Fly  1174 GSIVLWF---------GFLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVI 1229
            ||:.::|         |...|:.:.:|....|.|       .|:..:.:..::|..:..::..:.
Zfish  1047 GSLAVYFAILFAMNSNGIFTIFPNQFPFIGSARN-------SLNQKIVWLVILLNTVVCIMPMLA 1104

  Fly  1230 CKLVHNTVFKTLTEAVR----ETEIRRSDISEVMNEPRSSDSGFGYAL------GKLIRSSHIL- 1283
            .:.:...::.|.|:.||    .|..:|.....:....|:|.....||.      |:||.|...:
Zfish  1105 VRFIKTDLYPTHTDKVRLLQQATRRQRPQEQNLRRVRRTSSRRSAYAFSHQQGYGELITSGKNMK 1169

  Fly  1284 ---ISHDHHPVSESSR--------TSNLRVENLEMEADTE 1312
               .|...:|:|..||        ::|.|....:.|...|
Zfish  1170 VPTSSTSTYPLSSPSRAPGEKGTTSANSRPSEHKQEVTVE 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	27/61 (44%)
		ATPase-Plipid	229..1247	CDD:273734	452/1088 (42%)
		E1-E2_ATPase	286..>371	CDD:278548	36/84 (43%)
		Cation_ATPase	645..741	CDD:289987	44/95 (46%)
		HAD_like	<942..1001	CDD:304363	39/58 (67%)
		PhoLip_ATPase_C	988..1240	CDD:292829	81/260 (31%)
atp8b4	XP_687715.4	PhoLip_ATPase_N	34..99	CDD:292826	31/77 (40%)
		ATPase-Plipid	48..1121	CDD:273734	450/1083 (42%)
		Cation_ATPase	493..591	CDD:289987	45/97 (46%)
		HAD_like	<830..861	CDD:304363	22/30 (73%)
		PhoLip_ATPase_C	861..1115	CDD:292829	81/260 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.730