DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and Atp8b1

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_001001488.2	Gene:	Atp8b1 / 54670	MGIID:	1859665	Length:	1251	Species:	Mus musculus

Alignment Length:	1279	Identity:	485/1279 - (37%)
Similarity:	702/1279 - (54%)	Gaps:	170/1279 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 NSNLGFIDSDTPNTPVTPVSGLQPPASVSTSVGGTLSSRRRSSNRKDSKGSILSRQSGKSRVSLL 178
            :|...|.:...||..|.|.|..:....:... |.|:...:...||:..|
Mouse     6 DSETTFDEESQPNDEVVPYSDDETEDELEDQ-GSTVEPEQNRVNREAEK---------------- 53

  Fly   179 AQRGLRMTASFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQP------------TKYGN 231
                          ||      |.|.....:.....:|:.    ..||            :||.:
Mouse    54 --------------KR------ETFRKDCTWQVKANDRKF----HEQPHFMNTKFFCIKESKYAS 94

  Fly   232 NRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKE 296
            |.|.|.||:..:|||..|||||:|.:|.:||::.|||.||::|....|||||||:.:|.::|||:
Mouse    95 NAIKTYKYNGFTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLLVLGITAIKD 159

  Fly   297 IIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMC 361
            :::|:.||:.|.|||:|:.|.:..|.:..::|.::.|||:|::..|.|.|||::|||||||.::|
Mouse   160 LVDDVARHKMDKEINNRTCEVIKDGRFKIIKWKDIQVGDVIRLKKNDFIPADILLLSSSEPNSLC 224

  Fly   362 FIETANLDGETNLKIRQALPATAELLETKD-LQRLEGRIECELPNRHLYEFNGVL--RETGKPPA 423
            ::|||.||||||||.:.||..|.:.|:.:| |...:|.||||.||..|.:|.|.|  :....|
Mouse   225 YVETAELDGETNLKFKMALEITDQYLQIEDNLATFDGFIECEEPNNRLDKFTGTLFWKNQSFP-- 287

  Fly   424 ALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISL 488
             |..|::|.||.::|||....|:|:::|.:||:||||.....||:.:|.|.|..:..:|::||.:
Mouse   288 -LDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMNYMVYTIFIVLILV 351

  Fly   489 CIISGLCNLFWTREHSETDWYLGLTDFKTKSL-GY-NLLTFFILYNNLIPISLQVTLELVRFLQA 551
            .....:.:.:|..:.....|||...:..|.|. |: |...:.|:.|.::||||.|::|::|..|:
Mouse   352 SAGLAIGHAYWEAQVGNYSWYLYDGENATPSYRGFLNFWGYIIVLNTMVPISLYVSVEVIRLGQS 416

  Fly   552 IFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERT 616
            .|||:|::||:.|.:|||.|||:.|||:||.:.|||||||||||||:|.||||.|.|.:|...|.
Mouse   417 HFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIMTFKKCCINGTIYGDHRD 481

  Fly   617 PEESQ-------------------------LVQNILGRHETSAVIEEFLELLSVCHTVIPERKEN 656
            ..:..                         |::.|....|..  :.:|..|||:||||:.:|.:
Mouse   482 ASQHSHSKIELVDFSWNTFADGKLAFYDHYLIEQIQSGKEPE--VRQFFFLLSICHTVMVDRID- 543

  Fly   657 GNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVR 721
            |.:.|.||||||.|||..|:.||:.|..||...:.::.||..:.|.||.:|:|.|.|||||:|||
Mouse   544 GQINYQAASPDEGALVNAARNFGFAFLARTQNTITVSELGSERTYNVLAILDFNSDRKRMSIIVR 608

  Fly   722 TPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQT 786
            |||..|:|:||||||||||||...... :::|...|:.|||:.||||||...:|....:.||:..
Mouse   609 TPEGSIRLYCKGADTVIYERLHRMNPT-KQETQDALDIFASETLRTLCLCYKEIEEKEFTEWNNK 672

  Fly   787 FDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQE 851
            |..||||..||:..|:.....||.:|.|||||||||:|||||||||:.|..|.|.||||||||:|
Mouse   673 FMAASVASSNRDEALDKVYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKE 737

  Fly   852 TAINIGYSCRLISHSMDIIILNEESLDA---TREVIHRHYGEFKSSSAKDA------------NV 901
            ||.|||::|.|::.  |..|...|.:::   ||....|:.|   ..|||.|            |.
Mouse   738 TAENIGFACELLTE--DTTICYGEDINSLLHTRMENQRNRG---GVSAKFAPPVYEPFFPPGENR 797

  Fly   902 ALVIDGT-----------------TLKYALSCDLR------------------NDFQDLCILCRV 931
            ||:|.|:                 .||:..:.:.|                  .:|.||...|..
Mouse   798 ALIITGSWLNEILLEKKTKRSKILKLKFPRTEEERRMRSQSRRRLEEKKEQRQKNFVDLACECSA 862

  Fly   932 VICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIA 996
            ||||||:|.|||.||::|.:...|:|||||||||||.||:.|::|:||||.||:||..:||||.|
Mouse   863 VICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFA 927

  Fly   997 QFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLF 1061
            |||||||||||||.|:|.|:.|.:.|.||||....::..|::.::|:|.|..:|.|.|.|||||:
Mouse   928 QFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDWFITLYNVLY 992

  Fly  1062 TAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTK 1126
            :::|...|||.::..:.:..:|:|.||...|...|||.|.|::.:.:.:|.|:.||::||.||.
Mouse   993 SSLPVLLMGLLDQDVSDKLSLRFPGLYVVGQRDLLFNYKRFFVSLLHGVLTSMVLFFIPLGAYL- 1056

  Fly  1127 EVIWSDGKT-SDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYS--- 1187
            :.:..||:. |||......|.:.:::||..:.||.|:.||::...:|:|||.|:||.:..:.
Mouse  1057 QTVGQDGEAPSDYQSFAVTVASALVITVNFQIGLDTSYWTFVNAFSIFGSIALYFGIMFDFHSAG 1121

  Fly  1188 -HVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVR----- 1246
             ||  :|..|..|.|.....|..|..:..::|.....||..|..:.:..|::.:.::.::
Mouse  1122 IHV--LFPSAFQFTGTASNALRQPYIWLTIILTVAVCLLPVVAIRFLSMTIWPSESDKIQKHRKR 1184

  Fly  1247 ----ETEIRRSDISEVMNEPRSSDSGF----GYA----LGKLIR 1278
                |...||..:.......|.|...|    |||    .|:.||
Mouse  1185 LKAEEQWKRRQSVFRRGVSSRRSAYAFSHQRGYADLISSGRSIR 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	27/73 (37%)
		ATPase-Plipid	229..1247	CDD:273734	453/1111 (41%)
		E1-E2_ATPase	286..>371	CDD:278548	37/84 (44%)
		Cation_ATPase	645..741	CDD:289987	52/95 (55%)
		HAD_like	<942..1001	CDD:304363	37/58 (64%)
		PhoLip_ATPase_C	988..1240	CDD:292829	94/256 (37%)
Atp8b1	NP_001001488.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		11/46 (24%)
		PhoLip_ATPase_N	86..142	CDD:292826	25/55 (45%)
		ATPase-Plipid	92..1179	CDD:273734	453/1101 (41%)
		E1-E2_ATPase	171..>234	CDD:278548	29/62 (47%)
		Cation_ATPase	534..628	CDD:289987	52/94 (55%)
		HAD_like	<875..919	CDD:304363	26/43 (60%)
		PhoLip_ATPase_C	919..1173	CDD:292829	94/256 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.730