DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8A and Atp8b2

DIOPT Version :9

Sequence 1:NP_001137651.1 Gene:ATP8A / 36488 FlyBaseID:FBgn0259221 Length:1350 Species:Drosophila melanogaster
Sequence 2:NP_001355579.1 Gene:Atp8b2 / 54667 MGIID:1859660 Length:1209 Species:Mus musculus


Alignment Length:1180 Identity:470/1180 - (39%)
Similarity:701/1180 - (59%) Gaps:106/1180 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   228 KYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVS 292
            :|.:|.|.|:||:.::|||..|||||:..:|.:||.:.|||.||::|....:||:|||:.:|:::
Mouse    47 QYASNCIKTSKYNIVTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTIT 111

  Fly   293 AIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEP 357
            |:|:..:|..||::||::|:|..:.|.:|.....:|..:.||||||:..|.|..|||:|||||||
Mouse   112 AVKDATDDYFRHKSDNQVNNRHSQVLINGVLQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEP 176

  Fly   358 QAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVL--RETGK 420
            ..:|:||||.||||||:|:|||:|.|:||.:...|.|.:|.:.||.||..|.:|:|.|  :|...
Mouse   177 HGLCYIETAELDGETNMKVRQAIPVTSELGDVSQLARFDGEVICEPPNNKLDKFSGTLYWKENKF 241

  Fly   421 PPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMIL 485
            |   |.|..:|.||.:||||.|.||:|:::|.:||||:||.....||:::|:|.||.:|.:|..|
Mouse   242 P---LSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFL 303

  Fly   486 ISLCIISGLCNLFWTRE-HSETDWYLGLTDFKTKSLGYNLLTFF---ILYNNLIPISLQVTLELV 546
            :.:.:|..:.|..|..| .:....||...:....:.....|:|:   |:.|.::||||.|::|::
Mouse   304 VCMGVILAIGNAIWEHEVGTRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVI 368

  Fly   547 RFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY 611
            |...:.|||:|.:|:..:..|||.|||:.||||||.|:|||||||||||||:|.|.||||.|:.|
Mouse   369 RLGHSYFINWDKKMFCMKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSY 433

  Fly   612 ------------TAERTPE-----------------ESQLVQNI-LGRHETSAVIEEFLELLSVC 646
                        ..|| ||                 :|.|::.: :|...|    .||..|||:|
Mouse   434 GDVFDVLGHKAELGER-PEPVDFSFNPLADKKFLFWDSSLLEAVKMGDPHT----HEFFRLLSLC 493

  Fly   647 HTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTS 711
            |||:.|.|..|.:.|.|.||||.|||..|:.||::|.:||||.:.::.||....|::|.:|:|.:
Mouse   494 HTVMSEEKNEGELYYKAQSPDEGALVTAARNFGFVFRSRTPKTITVHELGTAITYQLLAILDFNN 558

  Fly   712 SRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIR 776
            .|||||:|||.||.||:|:||||||::.:||.|..|.....|..||.|:|.||||||.||..|:.
Mouse   559 IRKRMSVIVRNPEGKIRLYCKGADTILLDRLHPPTQELLSSTTDHLNEYAGDGLRTLVLAYKDLD 623

  Fly   777 PDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIY 841
            .:.|:||::...:||:|..:||.:|......:|:::.|||||||||:||.|||||||.|..|.|.
Mouse   624 EEYYEEWARRRLQASLAQDSREDRLASIYEEVESDMMLLGATAIEDKLQQGVPETIALLTLANIK 688

  Fly   842 IWVLTGDKQETAINIGYSCRLISHSM-DIIILNEESLDATREVIHR-----------------HY 888
            ||||||||||||:||||||::::..| ::.::...::...||.:.:                 :.
Mouse   689 IWVLTGDKQETAVNIGYSCKMLTDDMTEVFVVTGHTVLEVREELRKARKKMVDSSHAVGNGFTYQ 753

  Fly   889 GEFKSS------SAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVE 947
            |...||      .|.....||||:|.:|.:||..|:..:|.:....|:.||||||:|:|||:|||
Mouse   754 GNLSSSKLTSVLEAVAGEYALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVE 818

  Fly   948 MVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWN 1012
            :|.:...|||||||||||||:||:.|::|:||||.||:||..|||||.:||::|||||||||.|:
Mouse   819 LVKKYKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWS 883

  Fly  1013 YARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCT 1077
            |.|:.|.:.|.||||....::..||..:.|:|.|.:::::.|.|||:::|::|..|||:|::...
Mouse   884 YLRMCKFLCYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVP 948

  Fly  1078 AETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDG-KTSDYLLM 1141
            .:..:.||.||:..|...|||.:.|:|.|...:..||.:|::|...:. |....|| :.:||...
Mouse   949 EQRSMEYPKLYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFA-EATRDDGTQLADYQSF 1012

  Fly  1142 GNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLL-IYSH-VWPMFKFASNFRGMDI 1204
            ...|.|.:::.|.::.||.|..||.:.|..||||:.::|..|. ::|: ::.||.....|.|...
Mouse  1013 AVTVATSLVIVVSVQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQFRFVGNAQ 1077

  Fly  1205 QLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEI------------------- 1250
            ..|:.|..:..:.|.....::..|..:.:..::...|::.||.|::                   
Mouse  1078 NTLAQPTVWLTIALTTAVCIMPVVAFRFLRLSLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTG 1142

  Fly  1251 -RRSDISEVMNEPRSSDSGFGYAL--GKLIRSSHILISHDHHPVSESSRTSNLRVENLEMEADTE 1312
             |||..:      .|...|||..:  ||.:|.|.:.:|      |.|:|:|:..:|:|..:....
Mouse  1143 SRRSGYA------FSHQEGFGELIMSGKNMRLSSLALS------SFSTRSSSSWIESLRRKKSDS 1195

  Fly  1313 QQQQSRQRQK 1322
            ....|...:|
Mouse  1196 ANSPSGGAEK 1205

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8ANP_001137651.1 PhoLip_ATPase_N 218..280 CDD:292826 23/51 (45%)
ATPase-Plipid 229..1247 CDD:273734 448/1080 (41%)
E1-E2_ATPase 286..>371 CDD:278548 38/84 (45%)
Cation_ATPase 645..741 CDD:289987 49/95 (52%)
HAD_like <942..1001 CDD:304363 38/58 (66%)
PhoLip_ATPase_C 988..1240 CDD:292829 84/254 (33%)
Atp8b2NP_001355579.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 12..36
P-type_ATPase_APLT_Dnf-like 50..991 CDD:319770 415/948 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1179..1209 6/27 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X168
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.830

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