Protein Alignment ATP8A and ATP8A2

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_057613.4
• Gene: ATP8A2 / 51761
• HGNCID: 13533
• Length: 1188
• Species: Homo sapiens
• Alignment Length: 1109
• Identity: 622/1109 - (56%)
• Similarity: 802/1109 - (72%)
• Gaps: 34/1109 - (3%)

  Fly   198 EDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFL 262
            ||:....:|.| |..:...|.|.||.|...|:.:|:|:|||||.::|||.||:||.||.:|.|||
Human    38 EDEMSRATSVG-DQLEAPARTIYLNQPHLNKFRDNQISTAKYSVLTFLPRFLYEQIRRAANAFFL 101

  Fly   263 LIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVR 327
            .||:|||||:|||||||||||||:.||:::.||||:||.|||:|||.:|.:....|.:|.|.|:.
Human   102 FIALLQQIPDVSPTGRYTTLVPLIIILTIAGIKEIVEDFKRHKADNAVNKKKTIVLRNGMWHTIM 166

  Fly   328 WSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDL 392
            |.|:.||||:||....:.|||::|||||||||||::|||||||||||||||.|..||::...:.|
Human   167 WKEVAVGDIVKVVNGQYLPADVVLLSSSEPQAMCYVETANLDGETNLKIRQGLSHTADMQTREVL 231

  Fly   393 QRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLM 457
            .:|.|.||||.||||||:|.|.|...||...|||.||:|.||..||||.||||||||:|.:||||
Human   232 MKLSGTIECEGPNRHLYDFTGNLNLDGKSLVALGPDQILLRGTQLRNTQWVFGIVVYTGHDTKLM 296

  Fly   458 KNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGY 522
            :|||.||||||.|:|:||.|||:||.||:.:.::|....|:|.|.|.|.:||:...|..:.:.||
Human   297 QNSTKAPLKRSNVEKVTNVQILVLFGILLVMALVSSAGALYWNRSHGEKNWYIKKMDTTSDNFGY 361

  Fly   523 NLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIF 587
            |||||.|||||||||||.||||:|::.||:|||:|.:||:..::|||||||||||||||.|||:|
Human   362 NLLTFIILYNNLIPISLLVTLEVVKYTQALFINWDTDMYYIGNDTPAMARTSNLNEELGQVKYLF 426

  Fly   588 SDKTGTLTQNVMEFKKCSIAGYVY----TAERTP------------------EESQLVQNILGRH 630
            ||||||||.|:|.||||||||..|    ...|.|                  ::.:|::||..||
Human   427 SDKTGTLTCNIMNFKKCSIAGVTYGHFPELAREPSSDDFCRMPPPCSDSCDFDDPRLLKNIEDRH 491

  Fly   631 ETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINAL 695
            .|:..|:|||.||:|||||:|| |:..|:||.|:||||.|||:||:|.|::|..|||..|.|.|:
Human   492 PTAPCIQEFLTLLAVCHTVVPE-KDGDNIIYQASSPDEAALVKGAKKLGFVFTARTPFSVIIEAM 555

  Fly   696 GVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEF 760
            |..:.:.:||||||:|.|||||:|||||..:::|:|||||.||:|||:...: :.|:||.|||.|
Human   556 GQEQTFGILNVLEFSSDRKRMSVIVRTPSGRLRLYCKGADNVIFERLSKDSK-YMEETLCHLEYF 619

  Fly   761 ASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQ 825
            |::||||||:|.||:..:.|:||.:.:.:||..|::|..:||:...:||.||.||||||||||||
Human   620 ATEGLRTLCVAYADLSENEYEEWLKVYQEASTILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQ 684

  Fly   826 DGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHRHYGE 890
            .|||||||:||.|.|.|||||||||||||||||||||:|.:|.:|:|.|:||||||..|.:|..:
Human   685 AGVPETIATLLKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALILLKEDSLDATRAAITQHCTD 749

  Fly   891 FKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNA 955
            ..:...|:.:|||:|||.|||||||.::|..|.||.:.|:.||||||||:||:|:|::|.:...|
Human   750 LGNLLGKENDVALIIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKA 814

  Fly   956 VTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLI 1020
            :|||||||||||.|||.|:||:||||.||:||...|||:||||.||::||||||||:|.|::|.|
Human   815 ITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRVTKCI 879

  Fly  1021 LYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYP 1085
            ||.|||||.||:||||||..:|:|||||||||.||||||:|||:|||.:|:||:.||.|:|:|:|
Human   880 LYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLRFP 944

  Fly  1086 MLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVI 1150
            .|||.:||.:.||.||||....|||:||:.|||.|:.|...:.:.:.|..:|||.:||:|||||:
Human   945 QLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNIVYTYVV 1009

  Fly  1151 VTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYFC 1215
            |||||||||.|.:||..:|||:|||::.|..|..|||.:||....|.:.||....:||:..|:..
Human  1010 VTVCLKAGLETTAWTKFSHLAVWGSMLTWLVFFGIYSTIWPTIPIAPDMRGQATMVLSSAHFWLG 1074

  Fly  1216 LMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRSSDSGFGYALGKLIRSS 1280
            |.|||...|:.||..:...:|..|||.|.|:|.|.:    |.|:.:....||.     ||.:...
Human  1075 LFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETK----SRVLGKAVLRDSN-----GKRLNER 1130

  Fly  1281 HILI 1284
            ..||
Human  1131 DRLI 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	544/910 (60%)
ATP8A2	NP_057613.4	ATPase-Plipid	68..1106	CDD:273734	601/1039 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1162..1188