DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ATP8A and ATP8A2

DIOPT Version :9

Sequence 1:NP_001137651.1 Gene:ATP8A / 36488 FlyBaseID:FBgn0259221 Length:1350 Species:Drosophila melanogaster
Sequence 2:NP_057613.4 Gene:ATP8A2 / 51761 HGNCID:13533 Length:1188 Species:Homo sapiens


Alignment Length:1109 Identity:622/1109 - (56%)
Similarity:802/1109 - (72%) Gaps:34/1109 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly   198 EDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFL 262
            ||:....:|.| |..:...|.|.||.|...|:.:|:|:|||||.::|||.||:||.||.:|.|||
Human    38 EDEMSRATSVG-DQLEAPARTIYLNQPHLNKFRDNQISTAKYSVLTFLPRFLYEQIRRAANAFFL 101

  Fly   263 LIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVR 327
            .||:|||||:|||||||||||||:.||:::.||||:||.|||:|||.:|.:....|.:|.|.|:.
Human   102 FIALLQQIPDVSPTGRYTTLVPLIIILTIAGIKEIVEDFKRHKADNAVNKKKTIVLRNGMWHTIM 166

  Fly   328 WSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDL 392
            |.|:.||||:||....:.|||::|||||||||||::|||||||||||||||.|..||::...:.|
Human   167 WKEVAVGDIVKVVNGQYLPADVVLLSSSEPQAMCYVETANLDGETNLKIRQGLSHTADMQTREVL 231

  Fly   393 QRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLM 457
            .:|.|.||||.||||||:|.|.|...||...|||.||:|.||..||||.||||||||:|.:||||
Human   232 MKLSGTIECEGPNRHLYDFTGNLNLDGKSLVALGPDQILLRGTQLRNTQWVFGIVVYTGHDTKLM 296

  Fly   458 KNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGY 522
            :|||.||||||.|:|:||.|||:||.||:.:.::|....|:|.|.|.|.:||:...|..:.:.||
Human   297 QNSTKAPLKRSNVEKVTNVQILVLFGILLVMALVSSAGALYWNRSHGEKNWYIKKMDTTSDNFGY 361

  Fly   523 NLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIF 587
            |||||.|||||||||||.||||:|::.||:|||:|.:||:..::|||||||||||||||.|||:|
Human   362 NLLTFIILYNNLIPISLLVTLEVVKYTQALFINWDTDMYYIGNDTPAMARTSNLNEELGQVKYLF 426

  Fly   588 SDKTGTLTQNVMEFKKCSIAGYVY----TAERTP------------------EESQLVQNILGRH 630
            ||||||||.|:|.||||||||..|    ...|.|                  ::.:|::||..||
Human   427 SDKTGTLTCNIMNFKKCSIAGVTYGHFPELAREPSSDDFCRMPPPCSDSCDFDDPRLLKNIEDRH 491

  Fly   631 ETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINAL 695
            .|:..|:|||.||:|||||:|| |:..|:||.|:||||.|||:||:|.|::|..|||..|.|.|:
Human   492 PTAPCIQEFLTLLAVCHTVVPE-KDGDNIIYQASSPDEAALVKGAKKLGFVFTARTPFSVIIEAM 555

  Fly   696 GVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEF 760
            |..:.:.:||||||:|.|||||:|||||..:::|:|||||.||:|||:...: :.|:||.|||.|
Human   556 GQEQTFGILNVLEFSSDRKRMSVIVRTPSGRLRLYCKGADNVIFERLSKDSK-YMEETLCHLEYF 619

  Fly   761 ASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQ 825
            |::||||||:|.||:..:.|:||.:.:.:||..|::|..:||:...:||.||.||||||||||||
Human   620 ATEGLRTLCVAYADLSENEYEEWLKVYQEASTILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQ 684

  Fly   826 DGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHRHYGE 890
            .|||||||:||.|.|.|||||||||||||||||||||:|.:|.:|:|.|:||||||..|.:|..:
Human   685 AGVPETIATLLKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALILLKEDSLDATRAAITQHCTD 749

  Fly   891 FKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNA 955
            ..:...|:.:|||:|||.|||||||.::|..|.||.:.|:.||||||||:||:|:|::|.:...|
Human   750 LGNLLGKENDVALIIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKA 814

  Fly   956 VTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLI 1020
            :|||||||||||.|||.|:||:||||.||:||...|||:||||.||::||||||||:|.|::|.|
Human   815 ITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRVTKCI 879

  Fly  1021 LYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYP 1085
            ||.|||||.||:||||||..:|:|||||||||.||||||:|||:|||.:|:||:.||.|:|:|:|
Human   880 LYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLRFP 944

  Fly  1086 MLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVI 1150
            .|||.:||.:.||.||||....|||:||:.|||.|:.|...:.:.:.|..:|||.:||:|||||:
Human   945 QLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKALEHDTVLTSGHATDYLFVGNIVYTYVV 1009

  Fly  1151 VTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYFC 1215
            |||||||||.|.:||..:|||:|||::.|..|..|||.:||....|.:.||....:||:..|:..
Human  1010 VTVCLKAGLETTAWTKFSHLAVWGSMLTWLVFFGIYSTIWPTIPIAPDMRGQATMVLSSAHFWLG 1074

  Fly  1216 LMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRSSDSGFGYALGKLIRSS 1280
            |.|||...|:.||..:...:|..|||.|.|:|.|.:    |.|:.:....||.     ||.:...
Human  1075 LFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETK----SRVLGKAVLRDSN-----GKRLNER 1130

  Fly  1281 HILI 1284
            ..||
Human  1131 DRLI 1134

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8ANP_001137651.1 PhoLip_ATPase_N 218..280 CDD:292826 38/61 (62%)
ATPase-Plipid 229..1247 CDD:273734 601/1039 (58%)
E1-E2_ATPase 286..>371 CDD:278548 47/84 (56%)
Cation_ATPase 645..741 CDD:289987 56/95 (59%)
HAD_like <942..1001 CDD:304363 37/58 (64%)
PhoLip_ATPase_C 988..1240 CDD:292829 138/251 (55%)
ATP8A2NP_057613.4 ATPase-Plipid 68..1106 CDD:273734 601/1039 (58%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1162..1188
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 328 1.000 Domainoid score I1166
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1264 1.000 Inparanoid score I172
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 1 1.000 - - otm40635
orthoMCL 1 0.900 - - OOG6_100089
Panther 1 1.100 - - LDO PTHR24092
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1985
SonicParanoid 1 1.000 - - X168
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

Return to query results.
Submit another query.