Protein Alignment ATP8A and Atp9b

DIOPT Version :9

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_006526569.1
• Gene: Atp9b / 50771
• MGIID: 1354757
• Length: 1167
• Species: Mus musculus
• Alignment Length: 1108
• Identity: 311/1108 - (28%)
• Similarity: 514/1108 - (46%)
• Gaps: 176/1108 - (15%)

  Fly   217 RIINLNGPQ--PTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRY 279
            |.:.|..|:  ..|:..|.|...||:..:|:|..|:|||:.:.|.:||:::..|.:|.:.....|
Mouse   115 RTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVVSCSQFVPALKIGYLY 179

  Fly   280 TTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVG---- 340
            |...||.|:|:|:..:|.|::.:|.:.|.|:|.:...:|.......|:.|::.|||:|.|.
Mouse   180 TYWAPLGFVLAVTIAREAIDEFRRFQRDKEMNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKAFL 244

  Fly   341 -----------------INTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLE 388
                             .|...|:|::.|.:||....|||.|..|||||:.|::.|:..|..|..
Mouse   245 SCGQHPLMYMLQASASFQNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWKLKVAVSCTQRLPA 309

  Fly   389 TKDLQRLEGRIECELPNRHLYEFNGVL-RETGKPPAALGNDQVLQRGAILRNTAW---------V 443
            ..||..:...:..:.|...::.|.|.. ||...||        :.....:.||.|         |
Mouse   310 LGDLFSISAYVYAQKPQLDIHSFEGTFTREDSDPP--------IHESLSIENTLWASTIVASGTV 366

  Fly   444 FGIVVYSGQETKLMKNSTSAPLKRSTVDKLTN--TQILMLFMILISLCIISGLCNLFWTREHSET 506
            .|:|:|:|:||:.:.|:::...|...:|...|  |:.|.|.::::|:.::        |.:....
Mouse   367 IGVVIYTGKETRSVMNTSNPKNKVGLLDLELNQLTKALFLALVVLSVVMV--------TLQGFAG 423

  Fly   507 DWYLGLTDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTP-AM 570
            .||            .||..|.:|::.:|||||:|.|::.:......|..|       .|.| .:
Mouse   424 PWY------------RNLFRFLLLFSYIIPISLRVNLDMGKAAYGWMIMKD-------ENIPGTV 469

  Fly   571 ARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERTPE-ESQLVQNILGRH---- 630
            .|||.:.||||.:.|:.:|||||||||.|.||:..:....|..:...| :|.::.:.|..|
Mouse   470 VRTSTIPEELGRLVYLLTDKTGTLTQNEMVFKRLHLGTVSYGTDTMDEIQSHVLNSYLQVHSQPS 534

  Fly   631 ---------------------ETSAVIEEFLELLSVCHTVIP------------------ERKEN 656
                                 ..|:.|.|.::.:::||.|.|                  :...:
Mouse   535 GHNPSSAPLRRSQSSTPKVKKSVSSRIHEAVKAIALCHNVTPVYEARAGITGETEFAEADQDFSD 599

  Fly   657 GNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINA-LGVRKRYEVLNVLEFTSSRKRMSLIV 720
            .|..|.|:||||.|||...:..|....:|....:::.. .|....|.:|.:..|||..|||.:||
Mouse   600 ENRTYQASSPDEVALVRWTESVGLTLISRDLASMQLKTPSGQVLTYCILQMFPFTSESKRMGIIV 664

  Fly   721 RTPEN-KIKLFCKGAD----TVIYERLAPQGQAFREQTLRHLEE----FASDGLRTLCLAVADIR 776
            |.... :|..:.||||    |::             |....|||    .|.:|||||.:|...:.
Mouse   665 RDESTAEITFYMKGADVAMSTIV-------------QYNDWLEEECGNMAREGLRTLVVAKRTLT 716

  Fly   777 PDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIY 841
            .:.||::...:.:|.:::.:|..|:......:|..:.||..|.:||:||..|..|:..|.:|||.
Mouse   717 EEQYQDFESRYSQAKLSIHDRALKVAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIK 781

  Fly   842 IWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHRHYGEFKSSSAKDANVALVID 906
            ||:|||||.|||..|..|..|:|.:.||.:....:   :|...|.....|:    :..:.||||.
Mouse   782 IWMLTGDKLETATCIAKSSHLVSRTQDIHVFRPVT---SRGEAHLELNAFR----RKHDCALVIS 839

  Fly   907 GTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQ 971
            |.:|:..|.. ..::..:|...|..|:|||.||.|||.:|.::.|.|...|.|||||.|||:|||
Mouse   840 GDSLEVCLRY-YEHELVELACQCPAVVCCRCSPTQKAHIVTLLRQHTRKRTCAIGDGGNDVSMIQ 903

  Fly   972 KANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELW 1036
            .|:.||||.|.||.||:.|:|:||.|||::.|||:|||..:|.|.:.|..:..::.:.:..::..
Mouse   904 AADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAV 968

  Fly  1037 FAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKV 1101
            |:....::...|::.:.:..|..::|..|.|:: :.::....|..|.||.|||.....:..:.|.
Mouse   969 FSSVFYFASVPLYQGFLMVGYATIYTMFPVFSL-VLDQDVKPEMAILYPELYKDLTKGRSLSFKT 1032

  Fly  1102 FWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTW 1166
            |.||:..::.....|.:..|..:..|          ::.:..:.:|.:|:|..|...|...:|.|
Mouse  1033 FLIWVLISIYQGGILMYGALLLFEDE----------FVHVVAISFTALILTELLMVALTIRTWHW 1087

  Fly  1167 LTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRG---------MDIQLLSTPVFYFCLMLVPIT 1222
            |..:|.:.|:..:...|          .|.:.:.|         :|:..::|..|.:.:..:.:.
Mouse  1088 LMVVAEFLSLGCYVASL----------AFLNEYFGIGRVSFGAFLDVAFITTVTFLWKVSAITVV 1142

  Fly  1223 TLL 1225
            :.|
Mouse  1143 SCL 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	18/63 (29%)
		ATPase-Plipid	229..1247	CDD:273734	307/1094 (28%)
		E1-E2_ATPase	286..>371	CDD:278548	29/105 (28%)
		Cation_ATPase	645..741	CDD:289987	34/119 (29%)
		HAD_like	<942..1001	CDD:304363	34/58 (59%)
		PhoLip_ATPase_C	988..1240	CDD:292829	53/247 (21%)
Atp9b	XP_006526569.1	P-type_ATPase_APLT_Neo1-like	131..1076	CDD:319841	293/1011 (29%)
		Cation_ATPase	596..680	CDD:372530	27/83 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930