DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATP8A and atp2b3a

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	XP_005166875.1	Gene:	atp2b3a / 436745	ZFINID:	ZDB-GENE-040718-174	Length:	1299	Species:	Danio rerio

Alignment Length:	1001	Identity:	215/1001 - (21%)
Similarity:	368/1001 - (36%)	Gaps:	284/1001 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 SELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELL------ 387
            :|:.||||.:|......|||.:|:..::.:    |:.::|.||:: .:|:::.....||
Zfish   209 AEMVVGDIAQVKYGDLLPADGVLIQGNDLK----IDESSLTGESD-HVRKSIDKDPMLLSGTHVM 268

  Fly   388 -------------------------------ETKDLQR-LEGRIECELPNRHLYEFNGVLRETGK 420
                                           |.||.:: :......:.|:....|.|.:   .||
Zfish   269 EGSGKMLVTAVGVNSQTGIIFTLLGAGEMEEEKKDCKKEVNSNSSTQFPSVEAKEHNII---NGK 330

  Fly   421 PPAALGNDQ---------VLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTV--DKLT 474
            ....|.|:|         |......|::..        .|:..:..|...|.|.|..:|  .|||
Zfish   331 QDGTLENNQNKAKKQDEAVAMEMQPLKSAE--------GGEVEEKEKKKASVPKKEKSVLQGKLT 387

  Fly   475 NTQ----------------ILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGYN 523
            ...                ||||:.::.:..:            |.: .|   ||:.....:.|
Zfish   388 KLAVQIGKAGLVMSAITVIILMLYFVIKTFIV------------HKQ-PW---LTECTPIYVQY- 435

  Fly   524 LLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFS 588
            .:.|||:...::.:::...|.|.   ..|.:.|.::...:::|   :.|..:..|.:|....|.|
Zfish   436 FVKFFIIGVTVLVVAVPEGLPLA---VTISLAYSVKKMMKDNN---LVRHLDACETMGNATAICS 494

  Fly   589 DKTGTLTQNVMEFKKCSIAGYVYTAERTPEESQLVQNILGRHETSAVIEEFLELLS------VCH 647
            |||||||.|.|...:..|...::....||::               :....|||:|      ..:
Zfish   495 DKTGTLTTNRMTVVQIYIGDQLFRDIPTPDQ---------------INPRTLELISSAIAVNCAY 544

  Fly   648 T--VIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVL-NVLEF 709
            |  ::|..|| |.:.....:..|.||:      |.:.|.:.    :..|:..:...|:| .|..|
Zfish   545 TSKIMPADKE-GGLPKQVGNKTECALL------GLVLDLKQ----DYQAVREQIPEELLYKVYTF 598

  Fly   710 TSSRKRMSLIVRTPENKIKLFCKGADTVIYER----LAPQGQ--AFR-----EQTLRHLEEFASD 763
            .|.||.||.:::.|:...:|:.|||..::.::    |:..|:  |||     |...:.:|..|.|
Zfish   599 NSVRKSMSTVIQMPDGSFRLYSKGASEILLKKCSFILSRDGEARAFRARDKDEMVKKVIEPMACD 663

  Fly   764 GLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGV 828
            ||||:|:|..::..|...:|....|                   |.:||..:....|||.::..|
Zfish   664 GLRTICIAYRELPADPLPDWDNETD-------------------IVSNLTCITVVGIEDPVRPEV 709

  Fly   829 PETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHRHYGEFKS 893
            |:.|.....|||.:.::|||...||..|...|.:|....|.:.:  |..|..|. |....||.:.
Zfish   710 PDAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIHPGDDFLCM--EGKDFNRR-IRNEKGEIEQ 771

  Fly   894 SSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQST----N 954
            ..         ||.                   |..::.:..|.||..|..:|:.:..||    .
Zfish   772 ER---------IDK-------------------IWPKLRVLARSSPTDKHTLVKGIIDSTVVEQR 808

  Fly   955 AVTLAIGDGANDVAMIQKANVG--IGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWN-YARI 1016
            .|....|||.||...::||:||  :||:|.:  .|..|||..:....:...:..|....| |..|
Zfish   809 QVVAVTGDGTNDGPALKKADVGFAMGIAGTD--VAKEASDIILTDDNFSSIVKAVMWGRNVYDSI 871

  Fly  1017 SKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFT--AMPPFA-MGLFEKFCTA 1078
            ||.:.:....||        .||...::|..:.:...:....:|:.  .|..|| :.|..:..|.
Zfish   872 SKFLQFQLTVNV--------VAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTE 928

  Fly  1079 ETMIRYP----------MLYKTSQNAKLFNVKVFWIWIF------------NALLHSVFLFWLPL 1121
            ..::|.|          .:.|......::.:.:.:..:|            :|.|||.     |.
Zfish   929 ALLLRKPYGRNNPLISRTMMKNILGHAVYQLVIIFTLLFAGERIFDIDSGRDAPLHSP-----PS 988

  Fly  1122 AAYTKEVIWS-----------------------DGKTSDYLLMGNLVYTYVIVTVCLKAG----- 1158
            ..||  :|::                       ||..|:.:....::.|:.|..|.::.|
Zfish   989 EHYT--IIFNTFVLMQLFNEINARKIHGERNVFDGIFSNPIFCSIVLGTFAIQIVIVQFGGKPFS 1051

  Fly  1159 ---LITNSWTWLTHLA----IWGSIV 1177
               |....|.|...:.    :||.::
Zfish  1052 CSPLNVEQWLWCLFVGMGELLWGQLI 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826
		ATPase-Plipid	229..1247	CDD:273734	215/1001 (21%)
		E1-E2_ATPase	286..>371	CDD:278548	12/41 (29%)
		Cation_ATPase	645..741	CDD:289987	25/98 (26%)
		HAD_like	<942..1001	CDD:304363	21/64 (33%)
		PhoLip_ATPase_C	988..1240	CDD:292829	44/251 (18%)
atp2b3a	XP_005166875.1	ATPase-IIB_Ca	23..1082	CDD:273668	215/1001 (21%)
		Cation_ATPase_N	57..116	CDD:279080
		E1-E2_ATPase	164..484	CDD:278548	57/313 (18%)
		Cation_ATPase	545..634	CDD:289987	25/99 (25%)
		HAD	627..825	CDD:289480	61/247 (25%)
		Cation_ATPase_C	899..1077	CDD:279079	30/184 (16%)
		ATP_Ca_trans_C	1122..1198	CDD:289209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000