Protein Alignment ATP8A and ATP8B

DIOPT Version :9

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Alignment Length: 1760
• Identity: 522/1760 - (29%)
• Similarity: 781/1760 - (44%)
• Gaps: 512/1760 - (29%)

  Fly    13 RSPDH--GSVDDPDGCLRNHLGSSASQRRRQQRIAQQRQDSWFRHSMPPAINRDFESLEHLTPRA 75
            |:|..  |:||:| |........||..:|.:          ||:.:         .|.::...|.
  Fly    41 RTPTKGAGNVDEP-GIEAPEASCSAPSKRTR----------WFQFA---------RSSKNRRKRL 85

  Fly    76 SDGLDEQLAASVSHSVHSGGSVTLC-GPPDHSSIHLNSANSNLGFIDSDTPNTP---------VT 130
            ....||.:......:....||...| ..|:         ..|:| ..:.|..||         :.
  Fly    86 HCNEDEDVKQPERRNSDLEGSPRACLAQPE---------GMNIG-SSTQTIATPLMIGDSFYSLA 140

  Fly   131 PVSGLQPPASVSTSVGGTLSSRRRSSNRKDSKGSILSRQSGKSRVSLLAQRGLRMTASFLRRKRT 195
            |..|..||   :.|....|..:|..|...:||             |:.:.|.|    |.:||:|:
  Fly   141 PGGGNPPP---NKSDDQELYKQRDPSVTSESK-------------SVPSLRRL----SQIRRRRS 185

  Fly   196 EYEDDEDFTSSAGYDADDGERRIINLNGPQ---PTKYGNNRITTAKYSFISFLPAFLFEQFRRYS 257
            .|...|:            ||| |..|..:   ..||.||.|.|:|||..:|||..|.|||:|.:
  Fly   186 SYYFSEN------------ERR-IRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLA 237

  Fly   258 NCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGS 322
            |.:||.:.:||.||.:|.....||.:||:.:|:::|:|:..:||:||.:|:::|:|..:.|.:|.
  Fly   238 NFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGK 302

  Fly   323 WCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELL 387
            ....:|||:.|||:|::..|.|..||.:|||:|||..:||||||.||||||||.:|.|..|.||.
  Fly   303 LVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELG 367

  Fly   388 ETKD-LQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSG 451
            :..| |....|.|.||.||..|.:|:|.|...|: ..||.|:::|.||.:||||.|.:|:||::|
  Fly   368 DRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQ-RFALDNEKILLRGCVLRNTQWCYGVVVFAG 431

  Fly   452 QETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTR------------EHS 504
            .:||||:||.....|.:.||:|.|..|:.:.:.|:|:|.:..:....|..            ||.
  Fly   432 VDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHI 496

  Fly   505 ETDWYLGLTDFKTKSLGYNLLTFF---ILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESN 566
            ....|:     .|.:....||.||   |:.|.::||||.|::|::||:|:..||:|.|||:..:|
  Fly   497 IPKDYI-----PTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTN 556

  Fly   567 TPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY--------------TAERT- 616
            |.|.|||:.||||||.::|||||||||||||:|.|.||||.|..|              |.::|
  Fly   557 TYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTI 621

  Fly   617 ----------------------------------------------------------------- 616
                                                                             
  Fly   622 FQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSA 686

  Fly   617 -------------------PEESQ--------------------------------------LVQ 624
                               |..||                                      .:|
  Fly   687 PPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQ 751

  Fly   625 NILGR---------------------HETS---------------------AVIEE--------- 638
            ..|.|                     |.:|                     .||.:
  Fly   752 RQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEP 816

  Fly   639 ----------------------------------------------------------------- 638
                                                                             
  Fly   817 QSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEH 881

  Fly   639 ---FLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKR 700
               |..||::||||:.|..: |.:.|.|.||||.|||..|:.||::|.||||..:.|..:|..:.
  Fly   882 SHVFFRLLALCHTVMAETVD-GKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEE 945

  Fly   701 YEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGL 765
            ||:||:|:|.:.|||||:|:|..::.: |:|||||.|||:||....:..:.:|..||.:||.:||
  Fly   946 YELLNILDFNNVRKRMSVILRRGDSMV-LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGL 1009

  Fly   766 RTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPE 830
            |||.||...:....|.:|.....:|::::.:||.||......||:.::|:|.|||||:||||||:
  Fly  1010 RTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPK 1074

  Fly   831 TIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSM-DIIILNEESLDATREVIHRH------Y 888
            :||:|.:|||.|||||||||||||||||||:|::..: |:.|::..|::...:.:.:.      |
  Fly  1075 SIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIY 1139

  Fly   889 GEFK------------------------------------------------------------- 892
            ..|:
  Fly  1140 NRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKG 1204

  Fly   893 ----------------------SSSAKDANV--ALVIDGTTLKYALSCDLRNDFQDLCILCRVVI 933
                                  :|...|.|.  |||::|.:|.:.||.:|.|.|.|:...|:.||
  Fly  1205 GPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVI 1269

  Fly   934 CCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQF 998
            ||||:|:|||.|||::.::.||||||||||||||:||:.|::|:||||.|||||..:||||||||
  Fly  1270 CCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQF 1334

  Fly   999 RYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTA 1063
            |||:|||||||.|:|.|:.|.:.|.||||....:...|::::.|:|.|.:|:...|.:||:.:|:
  Fly  1335 RYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTS 1399

  Fly  1064 MPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEV 1128
            :|..|:|:||:..:.:..:.:|.||.....::|||::.|...:.:....|:.||.:|...|...|
  Fly  1400 LPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGV 1464

  Fly  1129 IWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMF 1193
            ..:....||::.:|.:|.|.:||....:..|.|:.||.:.|:.||||:|.:|.....|::|
  Fly  1465 SANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYV---- 1525

  Fly  1194 KFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVIC-KLVHNTVFKTLTEAVRETEIRR----- 1252
             ....:.|...|.:....|: ..||:.:..|:..|:. |.....|..:|::.:|:..:::
  Fly  1526 -IGGPYVGSLTQAMKDLTFW-VTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRA 1588

  Fly  1253 -SDISEVMNE---PRSSDSGFGYA----LGKLIRSSHIL-------------------ISHD--- 1287
             ||:....:.   .||..||:.:|    .|:||.|..|:                   :.|:
  Fly  1589 SSDVRRTASSRRGRRSVRSGYAFAHQEGFGRLITSGKIMHKLPQDFAFPLGLGTKKTQVLHNNLN 1653

  Fly  1288 --------------HHPVSESSRTSNLRVENLEMEADTEQQQQSRQRQKWRGGQVATGVARSARN 1338
                          ||.|:.::...:.:.:|....||.....:.      .||....|...|...
  Fly  1654 SADGPNSKGNNVTGHHMVNNNTNMRHNQNQNHSSMADITADGRG------NGGDDGRGSGGSDDM 1712

  Fly  1339 STTSP 1343
            |..:|
  Fly  1713 SPRAP 1717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	27/64 (42%)
		ATPase-Plipid	229..1247	CDD:273734	446/1382 (32%)
		E1-E2_ATPase	286..>371	CDD:278548	37/84 (44%)
		Cation_ATPase	645..741	CDD:289987	47/95 (49%)
		HAD_like	<942..1001	CDD:304363	41/58 (71%)
		PhoLip_ATPase_C	988..1240	CDD:292829	83/252 (33%)
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	28/65 (43%)
		Cation_ATPase	891..985	CDD:289987	47/95 (49%)
		HAD_like	<1261..1324	CDD:304363	40/62 (65%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	83/252 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445304
Domainoid	1	1.000	92	1.000	Domainoid score	I1716
eggNOG	1	0.900	-	-		E2759_KOG0206
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11922at33392
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	P	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
	9	8.750