Protein Alignment ATP8A and ATP9B

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_011524265.1
• Gene: ATP9B / 374868
• HGNCID: 13541
• Length: 1174
• Species: Homo sapiens
• Alignment Length: 1102
• Identity: 314/1102 - (28%)
• Similarity: 517/1102 - (46%)
• Gaps: 159/1102 - (14%)

  Fly   217 RIINLNGPQ--PTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRY 279
            |.:.|..|:  ..|:..|.|...||:..:|:|..|:|||:.:.|.:||:|:..|.:|.:.....|
Human   117 RTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLY 181

  Fly   280 TTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTF 344
            |...||.|:|:|:..:|.|::.:|.:.|.|:|.:...:|.......|:.|::.|||:|.|..|..
Human   182 TYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQR 246

  Fly   345 FPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLY 409
            .|:|::.|.:||....|||.|..|||||:.|::.|:..|.:|....||..:...:..:.|...::
Human   247 IPSDMVFLRTSEKAGSCFIRTDQLDGETDWKLKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIH 311

  Fly   410 EFNGVL-RETGKPPAALGNDQVLQRGAILRNTAW---------VFGIVVYSGQETKLMKNSTSAP 464
            .|.|.. ||...||        :.....:.||.|         |.|:|:|:|:||:.:.|:::..
Human   312 SFEGTFTREDSDPP--------IHESLSIENTLWASTIVASGTVIGVVIYTGKETRSVMNTSNPK 368

  Fly   465 LKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGYNLLTFFI 529
            .|...:|...|.....||:.|::|.|:      ..|.:.....||            .||..|.:
Human   369 NKVGLLDLELNRLTKALFLALVALSIV------MVTLQGFVGPWY------------RNLFRFLL 415

  Fly   530 LYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTL 594
            |::.:|||||:|.|::.:.:      |...|..:|:....:.|||.:.||||.:.|:.:||||||
Human   416 LFSYIIPISLRVNLDMGKAV------YGWMMMKDENIPGTVVRTSTIPEELGRLVYLLTDKTGTL 474

  Fly   595 TQNVMEFKKCSIAGYVYTAERTPE------------ESQLVQNILG--------------RHETS 633
            |||.|.||:..:....|.|:...|            :||...|..|              |...|
Human   475 TQNEMIFKRLHLGTVSYGADTMDEIQSHVRDSYSQMQSQAGGNNTGSTPLRKAQSSAPKVRKSVS 539

  Fly   634 AVIEEFLELLSVCHTVIP---------ERKE---------NGNMIYHAASPDERALVEGAQKFGY 680
            :.|.|.::.:.:||.|.|         |..|         :.|..|.|:||||.|||:..:..|.
Human   540 SRIHEAVKAIVLCHNVTPVYESRAGVTEETEFAEADQDFSDENRTYQASSPDEVALVQWTESVGL 604

  Fly   681 IFDTRTPKYVEINA-LGVRKRYEVLNVLEFTSSRKRMSLIVRTPEN-KIKLFCKGADTVIYERLA 743
            ...:|....:::.. .|....:.:|.:..|||..|||.:|||.... :|..:.||||..    ::
Human   605 TLVSRDLTSMQLKTPSGQVLSFCILQLFPFTSESKRMGVIVRDESTAEITFYMKGADVA----MS 665

  Fly   744 PQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEW------------------------- 783
            |..| :.:.........|.:|||||.:|...:..:.||::
Human   666 PIVQ-YNDWLEEECGNMAREGLRTLVVAKKALTEEQYQDFEPMQSSSVESTHSTYTCAHRRLPLC 729

  Fly   784 -SQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTG 847
             ...:.:|.:::.:|..|:......:|..:.||..|.:||:||..|..|:..|.:|||.||:|||
Human   730 PQSRYTQAKLSMHDRSLKVAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKIWMLTG 794

  Fly   848 DKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHRHYGEFKSSSAKDANVALVIDGTTLKY 912
            ||.|||..|..|..|:|.:.||.|..:.:   :|...|.....|:    :..:.||||.|.:|:.
Human   795 DKLETATCIAKSSHLVSRTQDIHIFRQVT---SRGEAHLELNAFR----RKHDCALVISGDSLEV 852

  Fly   913 ALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGI 977
            .|.. ..::|.:|...|..|:|||.||.|||.:|.::.|.|...|.|||||.|||:|||.|:.||
Human   853 CLKY-YEHEFVELACQCPAVVCCRCSPTQKARIVTLLQQHTGRRTCAIGDGGNDVSMIQAADCGI 916

  Fly   978 GISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSG 1042
            ||.|.||.||:.|:|:||.|||::.|||:|||..:|.|.:.|..:..::.:.:..::..|:....
Human   917 GIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAVFSSVFY 981

  Fly  1043 WSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIF 1107
            ::...|::.:.:..|..::|..|.|:: :.::....|..:.||.|||.....:..:.|.|.||:.
Human   982 FASVPLYQGFLMVGYATIYTMFPVFSL-VLDQDVKPEMAMLYPELYKDLTKGRSLSFKTFLIWVL 1045

  Fly  1108 NALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAI 1172
            .::.....|.:..|..:          .|:::.:..:.:|.:|:|..|...|...:|.||..:|.
Human  1046 ISIYQGGILMYGALVLF----------ESEFVHVVAISFTALILTELLMVALTVRTWHWLMVVAE 1100

  Fly  1173 WGSIVLWFGFLLIYSHVWPMFKFASNFRG---------MDIQLLSTPVFYFCLMLVPITTLL 1225
            :.|:..:...|          .|.:.:.|         :|:..::|..|.:.:..:.:.:.|
Human  1101 FLSLGCYVSSL----------AFLNEYFGIGRVSFGAFLDVAFITTVTFLWKVSAITVVSCL 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	291/970 (30%)
ATP9B	XP_011524265.1	P-type_ATPase_APLT_Neo1-like	133..1083	CDD:319841	296/1005 (29%)
		Cation_ATPase	577..661	CDD:463817	26/83 (31%)