DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and Atp11b

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	XP_038959540.1	Gene:	Atp11b / 361929	RGDID:	1561719	Length:	1175	Species:	Rattus norvegicus

Alignment Length:	1094	Identity:	416/1094 - (38%)
Similarity:	627/1094 - (57%)	Gaps:	91/1094 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 PTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILS 290
            |.|:.:|||.::||:..:|:|..|||||||.:|.:||:|.::|.:.: :||...|:.:||.|:::
  Rat    36 PQKFIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLMID-TPTSPITSGLPLFFVIT 99

  Fly   291 VSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSS 355
            |:|||:..||..||.:|||:|...:..:.||.....|...:.||||:::..:..|||||:||||.
  Rat   100 VTAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSD 164

  Fly   356 EPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNG------V 414
            .....|.:.||:||||||||...::|.||.|....:|..|...|||:.|...||.|.|      .
  Rat   165 RLDGSCHVTTASLDGETNLKTHVSVPETAVLQTVANLDSLIAVIECQQPEADLYRFMGRMIITQQ 229

  Fly   415 LRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQIL 479
            :.|..:|   ||.:.:|.|||.|:||..:||:.||:|.|||:..|..|...|||.|:|..||.::
  Rat   230 MEEIVRP---LGPESLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLI 291

  Fly   480 MLFMILISLCIISGLCNLFWTREHS-ETDWYLGLTDFK---TKSLGY--NLLTFFILYNNLIPIS 538
            :..:||||..|||.:....|..|.. :..||...|:.:   :|.|.:  :.|.|.:|||.:||||
  Rat   292 IYLIILISEAIISTILKYTWQAEEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFIIPIS 356

  Fly   539 LQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKK 603
            |.||:|:.:||.:.||.:|:::|||||:..|...||:||||||.|:|:|:|||||||:|.|:|::
  Rat   357 LYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRE 421

  Fly   604 CSIAGYVY--------------------------------------TAERTPEESQLVQNILGRH 630
            |||.|..|                                      |:.||..||:  ..::..|
  Rat   422 CSINGLKYQEINGKLVPEGPSPDSAEGNDPYLGSLSHLSSSAHLTATSLRTSPESE--TELIKEH 484

  Fly   631 ETSAVIEEFLELLSVCHTV-IPERKENG-------------NMIYHAASPDERALVEGAQKFGYI 681
            :.      |.:.:|:|||| |...:.:|             .:.|:|:||||:||||.|.:.|.|
  Rat   485 DL------FFKAVSLCHTVQISNVQTDGIGDGPWQPNLAPTQLEYYASSPDEKALVEAAARAGII 543

  Fly   682 FDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQG 746
            |...:.:.:|:..||..:||::|::|||.|.|:|||:||:.|..:..||.|||::.|..:.....
  Rat   544 FIGISEETMEVKVLGRVERYKLLHILEFDSDRRRMSVIVQAPSGEKLLFAKGAESSILPKCIGGE 608

  Fly   747 QAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENN 811
            .|   :|..|::|||..||||||:|......:.|::.::...:|..:||.||.||......||.:
  Rat   609 IA---KTRIHVDEFALKGLRTLCIAYRQFTAEEYEDVNRRLFEARTSLQRREEKLAGVFQYIEKD 670

  Fly   812 LRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDII-ILNEE 875
            |.||||||:||||||.|.|||.:|..|||.:|||||||.|||:::..||.....:|:|: ::|::
  Rat   671 LVLLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNILELINQK 735

  Fly   876 SLDATREVIHRHYGEFKSSSAKDANV--ALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVS 938
            |.....|.:.    :......:|..:  .||:|||:|..||. :....|.::|..|..|:|||::
  Rat   736 SDSGCAEQLR----QLARRITEDHVIQHGLVVDGTSLSLALR-EHEKLFMEVCRNCSAVLCCRMA 795

  Fly   939 PMQKAEVVEMVTQS-TNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQ 1002
            |:|||:|:.::..| ...:|||:|||||||:|||:|:|||||.|.||.|||..|||::|:|::|.
  Rat   796 PLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAVARFKFLS 860

  Fly  1003 RLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPF 1067
            :||.|||.:.|.||:.|:.|.||||||....:..:..|..:|.|.|::...:.|||:.||::|..
  Rat   861 KLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTSLPVL 925

  Fly  1068 AMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEV-IWS 1131
            ...|.|:......:...|.||:.....:|.::|.|..|......|:...|:.......|:. :..
  Rat   926 IYSLLEQHIDPHVLQSKPTLYRDISKNRLLSMKAFLYWTVLGFSHAFIFFFGSYFLIGKDTSLLG 990

  Fly  1132 DGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHV-WPMFKF 1195
            :|:.......|.||:|.:::||.:|..|.|:.|||:.||..||||:.:|.|.|.|..: || |..
  Rat   991 NGQMFGNWTFGTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFIFSLFYGGILWP-FLG 1054

  Fly  1196 ASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETE 1249
            :.|...:.|||||:...:|.::|:.::.|.:||:.|:....:..|.|:..:..|
  Rat  1055 SQNMYSVFIQLLSSGSAWFAILLMVVSCLFVDVVKKVFDRQLHPTSTQKAQLAE 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	23/53 (43%)
		ATPase-Plipid	229..1247	CDD:273734	413/1087 (38%)
		E1-E2_ATPase	286..>371	CDD:278548	34/84 (40%)
		Cation_ATPase	645..741	CDD:289987	43/109 (39%)
		HAD_like	<942..1001	CDD:304363	34/59 (58%)
		PhoLip_ATPase_C	988..1240	CDD:292829	83/253 (33%)
Atp11b	XP_038959540.1	P-type_ATPase_APLT_Dnf-like	41..978	CDD:319770	372/956 (39%)
Atp11b	XP_038959540.1	AA_permease_2	<959..>1085	CDD:424363	40/126 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820