Protein Alignment ATP8A and Atp10d

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_001414735.1
• Gene: Atp10d / 360932
• RGDID: 1588541
• Length: 1417
• Species: Rattus norvegicus
• Alignment Length: 1357
• Identity: 430/1357 - (31%)
• Similarity: 635/1357 - (46%)
• Gaps: 313/1357 - (23%)

  Fly   146 GGTLSSRRRSSNRKD-----SKGSILSRQSGKSRVSLLAQRGLRMTASFLRRKRTEYEDDEDFTS 205
            |.|.....||.|...     .|.....|.:||.||.:...:|.          :.|||
  Rat    18 GRTQGDDERSYNYSSLLACGGKSPQTPRPAGKHRVVIPHLQGF----------KDEYE------- 65

  Fly   206 SAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQI 270
                          ..:|    .|.||||.|.||:.::|:|..|||||.|.:|.:||.:.:|..:
  Rat    66 --------------RFSG----TYVNNRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWV 112

  Fly   271 PEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINH--RSIERLDSGSWCTVRWSELTV 333
            |.|....:..|::||:.:|::.|||:.:||.::::.|.:||:  ..:.......:....|..:||
  Rat   113 PLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDCCWKNVTV 177

  Fly   334 GDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGR 398
            ||.|::..|...|||::||.|::|..:|.|||:.||||:|||.||.:...||.....|.::...|
  Rat   178 GDFIRLSCNEIIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSR 242

  Fly   399 IECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSA 463
            ||||.||..|..|.|.|..:.|....|..:.:|.||..:|||..|.|||||:|.|||.|.|::..
  Rat   243 IECESPNNDLSRFRGFLEHSNKERVGLSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGP 307

  Fly   464 PLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHS--------ETDWYL---GLTDFKT 517
            ..|||.:::..||.:|...::||.:|:...|.:..|...:.        |.|..:   .||.|
  Rat   308 RYKRSKLERRANTDVLWCVLLLIVMCLTGALGHGIWLSRYENMLFFNIPEPDGRVLSPVLTGF-- 370

  Fly   518 KSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGM 582
                |...|..||...||||||.|::|:|:..|..||..|:|.|:|:.::....|..|:.|:||.
  Rat   371 ----YVFWTMIILLQVLIPISLYVSIEIVKLGQIYFIQSDVEFYNEKMDSTIQCRALNITEDLGQ 431

  Fly   583 VKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERTPEESQLVQNILGRHE---------------- 631
            ::|:|||||||||:|.|.|::||:||:.|..|...:..:..|..:...|
  Rat   432 IQYLFSDKTGTLTENKMVFRRCSVAGFDYCHEENAKRLESYQEAVSEEEECTDTLSGSLSLGSVA 496

  Fly   632 -------------------------TSAV------------------------------------ 635
                                     ||||
  Rat   497 RPRAQSCRTAHSRLPGKPLAQLSGSTSAVGNGEGSGEVLHSRQAAFSSPIETDVVPDTRLLDKFS 561

  Fly   636 -----------------------IEEFLELLSVCHTVI------PERK----------------- 654
                                   |.:|...|::|:||:      |.:|
  Rat   562 QITPQLFTRLDGAAQSAPLETLYIMDFFIALAICNTVVVSAPNQPRQKIGLSSLGGMPIKSLEEI 626

  Fly   655 ----------------------------------------------------------------- 654
                                                                             
  Rat   627 KNIFQKLSVRRSSSPSLASGKDSTSGTPCAFVSRISFFSRTKLSPPVEDESSQMDEIPQASNSAC 691

  Fly   655 ------EN--------------------GNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEIN 693
                  ||                    .|:.|.|.||||.|||..|:.:.....:|||:.|.::
  Rat   692 CTESEAENSDVGLPIDSAEALDGPPPLASNLCYEAESPDEAALVYAARAYHCTLRSRTPEQVVVD 756

  Fly   694 --ALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENK-IKLFCKGADTVIYE----------RLAPQ 745
              ||| ...:::|::|.|.|.|||||::||.|.:| :.::.||||:||.|          .|..|
  Rat   757 FAALG-PLTFQLLHILPFDSVRKRMSVVVRHPLSKQVVVYTKGADSVIMELLSVASSDGTNLEDQ 820

  Fly   746 GQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIEN 810
            ....||:|.|||:|:|..||||||:|...:....|.||.:....|..::.|||..|.::|..:||
  Rat   821 QMVIRERTQRHLDEYAKRGLRTLCVAKKVMSDTEYAEWLRNHFLAETSIDNREELLVESAMRLEN 885

  Fly   811 NLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEE 875
            .|.|||||.||||||:||||:|.:|..|||.||:|||||||||:||.|:|:|:.....:.|||.:
  Rat   886 KLTLLGATGIEDRLQEGVPESIEALHKAGIKIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQ 950

  Fly   876 SLDATREVIHRHYGEFKSSSAKDANVA-------------------LVIDGTTLKYALSCDLRND 921
            |.||...::.....|.:..:.....:|                   |||.|.||::||...|:..
  Rat   951 SEDACGMLMSAILEELQKRTQVSPELASPRKNFPQPPDPQVPGRAGLVITGKTLEFALQESLQKQ 1015

  Fly   922 FQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQ 986
            |.:|...|:.|||||.:|:||:|||::|....:.:|||||||||||:|||.|::|||:||.||:|
  Rat  1016 FLELTAWCQAVICCRATPLQKSEVVKLVRNHLHVMTLAIGDGANDVSMIQVADIGIGVSGQEGMQ 1080

  Fly   987 AACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFER 1051
            |..|||::|:|||:|.:||||||.|.|.|:|.:|||.|||||....:..|:..:.|:||..:.:.
  Rat  1081 AVMASDFAISQFRHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDY 1145

  Fly  1052 WTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFL 1116
            |.:..:|:|||::||...|:.||..:|||:::.|.||::.|.::.:....|||.:.:|...|:..
  Rat  1146 WVLIFFNLLFTSVPPIIYGVLEKDVSAETLLQLPELYQSGQRSEEYLPLTFWITLLDAFYQSLVC 1210

  Fly  1117 FWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFG 1181
            |::|...|       .|...|....||.:.|..::.:.|...:.:.|.||:..|.|.|||:.:|.
  Rat  1211 FFVPYFTY-------QGSDIDIFTFGNPLNTAALLIILLHLVIESKSLTWIHMLVIVGSILSYFF 1268

  Fly  1182 FLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVF 1238
            |.|.:..:.......||..|:..:.:..||||...:|.....||...:.:::..:||
  Rat  1269 FALAFGALCVTCNPPSNPYGIMQKHMLDPVFYLVCVLTTCVALLPRFVYRVLQGSVF 1325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	382/1147 (33%)
Atp10d	NP_001414735.1	None