Protein Alignment ATP8A and SPAC821.13c

DIOPT Version :9

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_001342913.1
• Gene: SPAC821.13c / 3361515
• PomBaseID: SPAC821.13c
• Length: 1562
• Species: Schizosaccharomyces pombe
• Alignment Length: 1561
• Identity: 453/1561 - (29%)
• Similarity: 699/1561 - (44%)
• Gaps: 391/1561 - (25%)

  Fly    22 DPDGCLRNHLGSSASQRRRQQRIAQQRQDSWFRHSMPPAINRDFESLEHLTPRASDGLDEQLAAS 86
            :.||....:.....:..||:. |..:.|||    ::|..|  |...|:.:.........:.:...
pombe    25 EEDGAFNWNAADDGTNERRED-IHVRFQDS----ALPLGI--DENELDEIDINGDSKKLDSVEVD 82

  Fly    87 VSHSVHSGGSVTLCGPPDHSSIHLNSANSNLGFIDSDTPNTPVTPVSGLQPPASVSTSVGGT--- 148
            .||.|:|.....|  .....|:...:|||.:..:...|.....:...|.:..|.||...|..
pombe    83 ESHDVNSPSDSRL--KSSFKSVLELTANSMVSVLTPSTKTEQTSKGKGKKKKAHVSFLEGPVEEI 145

  Fly   149 ------LSSRRRSSNRKDSKGSILSRQSGKSRVSLLAQRGLRMTASFLRR---KRTEYEDDEDFT 204
                  .:|.|.:|...:.:..|.................|:..::||..   :.|.|     ..
pombe   146 PLDDIEPTSPREASPVFNGRPPIPPEFLKSRHKEFTIPNPLQFISNFLSNLFSRDTRY-----LK 205

  Fly   205 SSAGYDADDGERRIINLNGPQPTK---------YGNNRITTAKYSFISFLPAFLFEQFRRYSNCF 260
            ||.|        |||.:|....:.         |..|.|.:::|:..:|:|..:..||.:.:||:
pombe   206 SSHG--------RIIIINPYDDSSQIDERTGKPYMQNSIVSSRYNKYNFVPLQIIAQFSKTANCY 262

  Fly   261 FLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRAD---NEINHRSIERLD--- 319
            ||||||:|.||..|.||.|||::||:..:|::.::|..::.:|:|.|   |.|..:.:..:|
pombe   263 FLLIAIMQMIPGWSTTGTYTTIIPLLIFISIAILREGFDNYRRYRQDRVENRIQTQVLRHVDVDP 327

  Fly   320 ----------------------SGSWCTVR----------------------------------- 327
                                  |.|..|:|
pombe   328 PIVEEHSSFFRRRRWRRSRSQESASRSTIRSTDEREPERTSEDPPQLPPSPSSPSSPALSVKPNI 392

  Fly   328 -------------------------WS-----ELTVGDIIKVGINTFFPADLILLSSSEPQAMCF 362
                                     |:     ::.|||||::..:...|||:|.|||..|....:
pombe   393 DPQPPLYNSTLTTTRSIPANKPTFFWASCDRKDVRVGDIIRLTSDQTLPADVIALSSPNPNGAIY 457

  Fly   363 IETANLDGETNLKIRQALPATAELL-ETKDLQRLEGRIECELPNRHLYEFNGVLR---ETGKPPA 423
            ||||.|||||:||.|........|. :..||.||.|....|.||..||.|||.::   ..|:.|
pombe   458 IETAALDGETSLKTRLVNSTLRSLCKDINDLIRLSGTCTVEDPNGDLYNFNGSMKLDSIQGEIP- 521

  Fly   424 ALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNST-SAPLKRSTVDKLTNTQILMLFMILIS 487
             |.|:.||.||:.||||:.:|.:|:::|:|:|:..|:. :..:|..::.|:||..::.:|.:::|
pombe   522 -LSNNDVLYRGSNLRNTSELFALVIFTGEESKIRMNAVRNVSVKAPSMQKVTNRIVIFIFALVVS 585

  Fly   488 LCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAI 552
            :.|........|.::.....||  ||:.|...:.. |::|.||||.::||||.|::|::|..|..
pombe   586 MAIYCTAAYFVWQKKVERKLWY--LTNSKLSFVPI-LVSFIILYNTMVPISLYVSMEIIRVFQTF 647

  Fly   553 FINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGY-------- 609
            .:..||::|:.|::|....|:|::.||||.|.::|||||||||.|:|.|:..|:.|:
pombe   648 LVQSDIDLYYPENDTRCEVRSSSILEELGQVTHVFSDKTGTLTDNIMLFRNLSVGGFAWQHVGAE 712

  Fly   610 ----VYTAERTPE-----ESQLVQNILGR------------HET-SAVIEEFLELLSVCHTVIPE 652
                |.|::::.:     :...::||.|.            |.| |..:..||..|::|||.:|.
pombe   713 NPKLVSTSQKSDDLDGEAKPPQLENIQGTTIQLLQYVHDNPHTTFSKRVRIFLLNLAICHTCLPS 777

  Fly   653 -RKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVR-------------KRYEV 703
             .:||....|.:.||||.|||..||:.|||...|     :|::|.:|             |.|.:
pombe   778 FDEENQIYKYQSISPDELALVHAAQQLGYIVIDR-----DIDSLTIRLHYPLDPHSHPIAKTYRI 837

  Fly   704 LNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFR------------------ 750
            ||::||||.||.||:|||.|..:|.|||||||:.|.:||.....|.|
pombe   838 LNIIEFTSKRKCMSVIVRMPNGRICLFCKGADSAIIKRLRLSNLAKRKDKSVTKAEQARKSIEID 902

  Fly   751 ----------------------------------------------------------------- 750
                                                                             
pombe   903 KAIIRNSQSTSRPSLTASRPSLSRRRNDYINNVTSWLDERREKMGVVRPRASTSILETRRRPAVG 967

  Fly   751 ---------------------------------------EQTLRHLEEFASDGLRTLCLAVADIR 776
                                                   |.|..|:..||:||||||..|...|.
pombe   968 RHSLAGGERLMEDKKYLSKQEEAEGSIYESLNHNDAKLFENTFEHVHAFATDGLRTLMYAHRFID 1032

  Fly   777 PDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIY 841
            ...||.|....|.|..:|.||:..|::||:|||.:|...|||||||:||.||||:|.||..|||.
pombe  1033 ESEYQSWKLVNDAALNSLSNRQQLLDEAADLIEKDLEFAGATAIEDKLQVGVPESINSLFRAGIK 1097

  Fly   842 IWVLTGDKQETAINIGYSCRLISHSMDIIIL--------NEESL--------------DATREVI 884
            .|:|||||:|||||||:||.:|.....::::        ::|::              |....:|
pombe  1098 FWMLTGDKKETAINIGHSCGVIKEYSTVVVMGSLDGVEGSDETVSGGQRLSLDRPPTNDPASLMI 1162

  Fly   885 HRHYGEFKSSSAKD-ANVALVIDGTTLKYALSCDLRND------FQDLCILCRVVICCRVSPMQK 942
            |:......:..:.. |::.:||||:||     .|:.||      |.:..:....|||||.|||||
pombe  1163 HQLISCMNAIHSNSLAHLVIVIDGSTL-----ADIENDPELFLLFINTAVEADSVICCRSSPMQK 1222

  Fly   943 AEVVEMVTQS-TNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLL 1006
            |.:|:.|..: ..||||||||||||:||||:|:|||||:|.||||||.:||:||.:|::|.:||.
pombe  1223 ALMVQKVRNTLEKAVTLAIGDGANDIAMIQEAHVGIGIAGREGLQAARSSDFSIGRFKFLIKLLF 1287

  Fly  1007 VHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGL 1071
            .||.|:|.|:||.||.:|||....::::.....:.|::||.|:|.|.:..:|.||:::....:|:
pombe  1288 CHGRWSYVRLSKYILGTFYKEQFFFLMQAIMQPFVGYTGQSLYESWGLTCFNTLFSSLCVIGLGI 1352

  Fly  1072 FEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAY-TKEVIWSDGKT 1135
            |||..:|.|:|..|.||:...|.:.||.:|::.|...|.:.:..:|::..:.: .||:  :|...
pombe  1353 FEKDLSASTVIAVPELYQKGINNEAFNWRVYFGWCSIAFIQAFLVFYVTYSLFGMKEL--NDNNI 1415

  Fly  1136 SDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVL------WFGFLLIYSHVWP--- 1191
            ..|   |.|::|..|..:..|...|.     :.::.|...|||      ||.|.:..|..:|
pombe  1416 FAY---GQLIFTAAIFIMNFKLVFIE-----MQYINIISIIVLVLTSLAWFLFNIFISEHYPDKN 1472

  Fly  1192 --------MFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRET 1248
                    :..|..|           |.::..::.|.:..|.||::.:::..|:..|.|:...|.
pombe  1473 LYLARSQFLHHFGKN-----------PSWWLTMLFVMVCALTIDIVAQMLRRTLRPTDTDIFVEM 1526

  Fly  1249 E 1249
            |
pombe  1527 E 1527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	25/70 (36%)
		ATPase-Plipid	229..1247	CDD:273734	408/1329 (31%)
		E1-E2_ATPase	286..>371	CDD:278548	32/177 (18%)
		Cation_ATPase	645..741	CDD:289987	48/109 (44%)
		HAD_like	<942..1001	CDD:304363	38/59 (64%)
		PhoLip_ATPase_C	988..1240	CDD:292829	74/269 (28%)
SPAC821.13c	NP_001342913.1	P-type_ATPase_APLT_Dnf-like	233..1401	CDD:319770	378/1182 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910