Protein Alignment ATP8A and CG4301

DIOPT Version :9

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_573125.1
• Gene: CG4301 / 32610
• FlyBaseID: FBgn0030747
• Length: 1342
• Species: Drosophila melanogaster
• Alignment Length: 1340
• Identity: 409/1340 - (30%)
• Similarity: 614/1340 - (45%)
• Gaps: 338/1340 - (25%)

  Fly   182 GLRMTASFLRRKRTEYEDDEDFTSSAGY--DADDGER-------RIINLNGPQPTK----YGNNR 233
            |.|........::|.:.|.|.|.....:  :...|.|       ..|.:.|||..|    .|.||
  Fly    11 GFRRIDRLGAHRQTPWADQESFHLKDAFLWNWHKGSRVSTINDWLQIQIGGPQDIKKKRPKGQNR 75

  Fly   234 ITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEII 298
            |.:.||:.|:|||..|.|||||.:|.:||::.|:..:.: ||....|:|:||:|:::|:|.|:..
  Fly    76 IKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPMTSLLPLVFVIAVTAAKQGY 139

  Fly   299 EDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFI 363
            |||.|:|.||.:|...:..:..|....::..::..|::|.|..:...|.||:||.|::|...|||
  Fly   140 EDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFI 204

  Fly   364 ETANLDGETNLK---IRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRETGKPPAA- 424
            .|||||||:|||   :.:.|| |.:|.|...|    |.||||.|...||.|||.:...|.....
  Fly   205 TTANLDGESNLKTLMVPRDLP-TVDLPEMHKL----GIIECESPTTDLYSFNGKIELKGGEGRVL 264

  Fly   425 -LGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISL 488
             |..:.||.||:.::||..|.|..||:|..:||..||.....|.::.:...|.     |:|:|.:
  Fly   265 PLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINR-----FLIVILV 324

  Fly   489 CIISGLCNLFWTREHSETD-----WYLG-LTD-FKTKSLGYNLLTFFILYNNLIPISLQVTLELV 546
            .:|:.:..|::.:.::|..     .||| .|| :..|....:.|:|.||:|.||||||.||:||.
  Fly   325 ALIAIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQ 389

  Fly   547 RFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY 611
            |.:.:.|:.:|:|:|..|::.|.:..|||||||||.:..:|||||||||:|.|.|::|||.|..:
  Fly   390 RVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGNKF 454

  Fly   612 TAERTPEESQLVQNILGRHETSAVIEEFLELLSVCHTV--------------------------I 650
            ..::|..|.:..:.:|..::.||....|.:.||:||||                          .
  Fly   455 LFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIKSGP 519

  Fly   651 PE--------------------------------------------------------------- 652
            ||
  Fly   520 PEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKR 584

  Fly   653 --------------RKENG---------------------------------------------- 657
                          |..||
  Fly   585 PVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWE 649

  Fly   658 ----------------------------------------------------------------- 657
                                                                             
  Fly   650 APSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAES 714

  Fly   658 ------------NMIYHAASPDERALVEGAQKFGYIF---DTRT------PKYVEINALGVRKRY 701
                        .:.|.|:||||:||||.....|.::   |..|      |.:::......:.|.
  Fly   715 QRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPRE 779

  Fly   702 EV---LNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASD 763
            |.   |:||||||.|||||:|||..:.|..::.|||::.::...|........:|..|:.:||..
  Fly   780 ETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAELVTKTDAHISDFARL 844

  Fly   764 GLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGV 828
            |||||.:|...|..:.||::.....:|:.:|:||:...|:....||:||.||||||:||.|||.|
  Fly   845 GLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDV 909

  Fly   829 PETIASLLDAGIYIWVLTGDKQETAINIGYSCRLI-----------SHSMDIIILNEESLDATRE 882
            .:|:.||..|||.||||||||.|||:||..||..|           ..:.:.::|:..:||  ||
  Fly   910 ADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKNREEMLLHLNALD--RE 972

  Fly   883 VIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVE 947
            :|   :|       .....||:|||.:|..||: :..::|:|:.:.|..|:|||:||:||:|||.
  Fly   973 II---FG-------IGQECALLIDGKSLGVALA-EASSEFRDVAVKCTAVLCCRLSPLQKSEVVS 1026

  Fly   948 MVTQST-NAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAW 1011
            ::..|. |..|.:||||||||:|||:|:|||||.|.||.|||..:|::.|:|..|:|||||||.:
  Fly  1027 LIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHY 1091

  Fly  1012 NYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFC 1076
            :..|:|.|:||.||||:....|...|..::.:|...:::...:.||||::|::|...:.:.||..
  Fly  1092 HSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPY 1156

  Fly  1077 TAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLA-AYTKEVIWSDGKTSDYLL 1140
            |.|.::|.|.|||.:.:.|..:...|.:|:..|:.|||.:|:.... .|...|:.:.|:|..:..
  Fly  1157 TEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSC 1221

  Fly  1141 MGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIW---GSIVLWFGFL---LIYSHVWPMFKFASNF 1199
            .|.|:...|:|.|.||.      |....:|:.|   ..|:...||:   :||           |.
  Fly  1222 FGTLLMWTVVVVVNLKL------WLESMYLSFWYIFTIIISILGFVVTTVIY-----------NV 1269

  Fly  1200 RGMDIQ----------LLSTPVFYFCLM-----LVPITTL 1224
            ..:|..          |.|.||:.:.::     |||..|:
  Fly  1270 INLDYDTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTI 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	27/65 (42%)
		ATPase-Plipid	229..1247	CDD:273734	396/1280 (31%)
		E1-E2_ATPase	286..>371	CDD:278548	31/84 (37%)
		Cation_ATPase	645..741	CDD:289987	44/333 (13%)
		HAD_like	<942..1001	CDD:304363	33/59 (56%)
		PhoLip_ATPase_C	988..1240	CDD:292829	76/259 (29%)
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	27/64 (42%)
		ATPase-Plipid	74..1317	CDD:273734	395/1277 (31%)
		E1-E2_ATPase	127..>345	CDD:278548	78/227 (34%)
		Cation_ATPase	<734..823	CDD:289987	33/88 (38%)
		HAD_like	<1036..1066	CDD:304363	21/29 (72%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	76/259 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11922at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850