DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and CG9981

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster

Alignment Length:	1076	Identity:	347/1076 - (32%)
Similarity:	569/1076 - (52%)	Gaps:	96/1076 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 NRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQI--PEVSPTGRYTTLVPLMFILSVSAI 294
            ||:||.||::.:|||...:|||||....:||:|.|:...  ..:||   ..:|:||:|::.::|:
  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISP---LVSLLPLLFVMIITAL 89

  Fly   295 KEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQA 359
            ||.:||..|.::|..:|...:..:.:|....:....:..||::.|..:...|.||:||.||....
  Fly    90 KEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQSSSADR 154

  Fly   360 MCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGR--IECELPNRHLYEFNGVLR-ETGKP 421
            .||:.||||||||||| ...:|....|....:||   |:  |.||..:..||.|||.|. .:|..
  Fly   155 KCFVNTANLDGETNLK-TICVPTNYLLAGDHELQ---GKDCIVCEPSSADLYTFNGRLELRSGND 215

  Fly   422 PAA--------LGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQI 478
            .|.        |..|.:|.||..:::|..|.|..:|:|..|||..||.....|.::.:|..|..:
  Fly   216 GAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASSEKYINRFM 280

  Fly   479 LMLFMILISLCIISGLCNLFWTREHSE-----TDWYLG-LTDFKTK-SLGYNLLTFFILYNNLIP 536
            :.|.:.:|.:.::     |:....|.|     |..|.| .|:|.:. .:..:.|:|.:|:|.::|
  Fly   281 VALIVGMIVVVVV-----LYLIERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLLFNYMVP 340

  Fly   537 ISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEF 601
            ||..:.:|:.|.....|::.|:.:|.||::.|.....||||||||.|..:|||||||||:|:|:|
  Fly   341 ISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLTKNLMKF 405

  Fly   602 KKCSIAGYVYTAERTPEESQLVQNILGRHETSAVIEEFLELLSVCHTV----------------I 650
            ..|.:.|..|..:.|...|:.........:..|......|.|:|||||                :
  Fly   406 VNCYVPGTNYQLQNTHLVSEGTDEKFELEKLDADAAVLFEALAVCHTVEVLQEVGDKTLESSESV 470

  Fly   651 PERKE--NGNMI--YHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGV-------RKRYEVL 704
            .|:..  :.|::  |.|:||||:||:||....|.:::.:     |.:.|.:       :.:::.|
  Fly   471 SEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQ-----ENDVLSICRYPSAEKVQFKRL 530

  Fly   705 NVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLC 769
            :||||:|.|:|||:|||...:.|.|:.|||::.|:.|.  :.....|||...:.::|.:||||:.
  Fly   531 HVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRC--KASPLVEQTDAQITKYAQNGLRTMA 593

  Fly   770 LAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIAS 834
            :....:..|....:.:.:.||:..|.||...:......:||.|.||||||:||.||:.|.||:.:
  Fly   594 VGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGETLEA 658

  Fly   835 LLDAGIYIWVLTGDKQETAINIGYSCRLISH-SMDIIILN---EESLDATREVIHRHYGEFKSSS 895
            |..||:.||||||||.|||.|||.:||.|.. |....|:|   ...|.|..::|
  Fly   659 LQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTTEPAELLARLDMI----------- 712

  Fly   896 AKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAI 960
            ..|....|::||||:...|....| .|.||.:.||.|:|||:||:||:|:|.::.:....:|.||
  Fly   713 GDDEPEVLIVDGTTITALLEHTPR-QFADLALRCRAVLCCRLSPLQKSEIVTLIKRRKKYITAAI 776

  Fly   961 GDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFY 1025
            |||||||:|||:|::||||:|.||.|||..:|:|||:|..|:||.||||.:|..|::.|:|:..|
  Fly   777 GDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHGHYNSQRLAFLVLFYCY 841

  Fly  1026 KNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKT 1090
            ||:.:......:.||..:|...::....:.|:::::.:.....:.:.:|..:.||::.:|.|||.
  Fly   842 KNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDKDYSEETLLSHPELYKP 906

  Fly  1091 SQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYT-KEVIWSDGKTSDYLLMGNLVYTYVIVTVC 1154
            ..:.:..::.||.:||.|..:....:|:...|... ..|:::.|:|:.:...|.::.|.:::...
  Fly   907 LAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTASFQTFGTMLITIIVIVGN 971

  Fly  1155 LKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLV 1219
            ||..|:.:..|:.....|..||..:    ::.::::.::.....:...:..|.|.|::.|
  Fly   972 LKLLLVAHYMTYRNFAMILASIAAF----MLTTYLYNLYTSGELYDVYNQFLSSLPIWLF----- 1027

  Fly  1220 PITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDI 1255
               |::..|.| |:.:.|.|.:.:..|:..::...:
  Fly  1028 ---TIICSVAC-LLPDFVIKVVNDMYRKVPLKSKPV 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	20/49 (41%)
		ATPase-Plipid	229..1247	CDD:273734	346/1066 (32%)
		E1-E2_ATPase	286..>371	CDD:278548	27/84 (32%)
		Cation_ATPase	645..741	CDD:289987	39/122 (32%)
		HAD_like	<942..1001	CDD:304363	32/58 (55%)
		PhoLip_ATPase_C	988..1240	CDD:292829	59/252 (23%)
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	18/37 (49%)
		ATPase-Plipid	28..1051	CDD:273734	346/1066 (32%)
		E1-E2_ATPase	84..>189	CDD:278548	36/108 (33%)
		Cation_ATPase	<489..568	CDD:289987	30/83 (36%)
		HAD_like	<758..807	CDD:304363	27/48 (56%)
		PhoLip_ATPase_C	804..1050	CDD:292829	60/258 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11922at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	P	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.750