Protein Alignment ATP8A and atp8b2

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_021322579.1
• Gene: atp8b2 / 323754
• ZFINID: ZDB-GENE-030131-2474
• Length: 1359
• Species: Danio rerio
• Alignment Length: 1278
• Identity: 473/1278 - (37%)
• Similarity: 695/1278 - (54%)
• Gaps: 148/1278 - (11%)

  Fly   190 LRRKRTEYEDDEDFTSSAGYDADDGERRIINLNG---PQPTKYGNNRITTAKYSFISFLPAFLFE 251
            |:||:      |..|||........|.|.:..|.   .:..:|.:|.|.|:||:.|:|||..|||
Zfish    25 LKRKK------EGLTSSTKIRKGAEEERRVRANDREYNEKFQYASNCIMTSKYNIITFLPVNLFE 83

  Fly   252 QFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIE 316
            ||:..:|.:||.:.|||.||::|....:||:|||:.:||::|:|:..:|..||::||::|:|..:
Zfish    84 QFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLSITAVKDATDDYFRHKSDNQVNNRQSQ 148

  Fly   317 RLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALP 381
            .|..|.....:|..:.||||||:..|.|..|||:|||||||..:|:||||.||||||:|:||:|.
Zfish   149 VLIGGILQKEKWMNVRVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQSLS 213

  Fly   382 ATAELLETKDLQRLEGRIECELPNRHLYEFNGVL--RETGKPPAALGNDQVLQRGAILRNTAWVF 444
            .|:||.:..:|.:.:|.:.||.||..|..|.|.|  ||...|   |.|..:|.||.:||||...:
Zfish   214 VTSELGDPNNLAQFDGEVVCEPPNNKLDRFCGTLYWRECKYP---LSNQNMLLRGCVLRNTESCY 275

  Fly   445 GIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTRE-----HS 504
            |:|:::|.:||||:||.....||:::|:|.||.:|.:|..|:.:.:|..:.|..|.:|     .|
Zfish   276 GLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAVWEKEVGALFQS 340

  Fly   505 ETDWYLGLTDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPA 569
            ...|...:.:|...:. .:..::.|:.|.::||||.|::|::|...:.|||:|..|:...|||.|
Zfish   341 FLPWDPPVDNFLFSAF-LSFWSYVIILNTVVPISLYVSVEVIRLGHSYFINWDRRMFCSRSNTAA 404

  Fly   570 MARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERTPEESQLVQNILGRHET-- 632
            .|||:.||||||.|:|||||||||||||:|.|.||||.|:.|..         |.|||...:.
Zfish   405 EARTTTLNEELGQVEYIFSDKTGTLTQNIMTFNKCSINGHAYGE---------VVNILAAQQKRV 460

  Fly   633 ------------------------------SAVIEEFLELLSVCHTVIPERKENGNMIYHAASPD 667
                                          ...:.||..:||:||||:.|.|..|.::|.|.|||
Zfish   461 QPLDFSSWNPLADRGFCFYDQSLLEAVMVGDPAVHEFFRVLSLCHTVMSEEKSEGELVYKAQSPD 525

  Fly   668 ERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCK 732
            |.|||..|:.||::|.:|||..:....||....|.:|.:|:|.:.|||||:|||.||.:|:|:||
Zfish   526 EGALVTAARNFGFVFRSRTPGTITTQELGKAVTYTLLAILDFNNIRKRMSVIVRNPEGRIRLYCK 590

  Fly   733 GADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNR 797
            |||||:.|||..........|..||.|:|.||||||.:|..|:..:.:.|||:.|..|..|...|
Zfish   591 GADTVLLERLHSCNHEVMTITSDHLNEYAVDGLRTLAVAYRDLSEEQWDEWSERFRGADKATDCR 655

  Fly   798 ESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRL 862
            |.:|..|...||.::.|||||||||:||:|||||||.|..|.|.||||||||||||:||||||::
Zfish   656 EDRLAAAYEEIEQDMMLLGATAIEDKLQEGVPETIAILSLANIKIWVLTGDKQETAVNIGYSCKM 720

  Fly   863 ISHSM-DIIILNEESLDATREVIHRHYGEFKSSS-----AKDANV-------------------- 901
            ::..| ::.|:|..::.:.||.:.:.......|:     .|:|..
Zfish   721 LTDDMTEVFIVNGHTVQSVREELRKARERMLESARTRDGGKEAEAQGWSGACAFGNGCGAGAAAA 785

  Fly   902 -----------------------------ALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRV 937
                                         ||:|.|.:|.:||..|:..:|.:....||.||||||
Zfish   786 AANWAPDESKCPPAQAPPSSLLESISGEFALIISGHSLAHALEADMEREFLETACACRAVICCRV 850

  Fly   938 SPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQ 1002
            :|:|||.|||:|.:...|||||||||||||:||:.|::|:||||.||:||..|||||.:|||:||
Zfish   851 TPLQKALVVELVKRHKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFRFLQ 915

  Fly  1003 RLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPF 1067
            |||||||.|:|.|:.:.:.|.||||....::..||..:.|:|.|.:::::.|.|||:::|::|..
Zfish   916 RLLLVHGRWSYLRMCRFLCYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVL 980

  Fly  1068 AMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSD 1132
            |||:|::....:..:.||.||:..|...|||.:.|:|.|...:..||.||::|.:..:.....:.
Zfish   981 AMGIFDQDVPEQRSLEYPKLYEPGQLNLLFNKREFFICIAQGIYTSVVLFFIPYSVLSHATQSNG 1045

  Fly  1133 GKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFG--FLLIYSHVWPMFKF 1195
            ...:||........|.:::.|.::..|.|..||.:.|..:|||:..:|.  |.:..|.::.:|..
Zfish  1046 VPLADYQTFAVTTATALVIVVSVQIALDTGYWTAINHFFVWGSLGTYFTILFAMHSSILFSIFPK 1110

  Fly  1196 ASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVIC-------KLVHNTVFKTLTEAVRETEI--- 1250
            ..:|.|.....|..||.:       :|..|..|||       :.:...:...|::.||.|::
Zfish  1111 QFHFLGSAHNTLGQPVVW-------LTIALATVICIAPVLAFRFLKLDLKPQLSDTVRYTQLVLQ 1168

  Fly  1251 -RRSDISEVMNEPRSSDSGFGYALGKL----IRSSHILISHDHHPVSESSRTSNLRVENLEMEAD 1310
             :|...........|:.:..|..||:|    .|.|....:|........:...|:|:.:|.:...
Zfish  1169 KKRKPGGRAARGVGSTGAAGGSGLGRLGRGGSRRSGYAFAHQEGFGELITSGKNMRLSSLALATF 1233

  Fly  1311 TEQQQQS----RQRQKWRGGQVATGVARSARNSTTS----PIT 1345
            ..:...|    .:|:|......|.....:..:.|||    ||:
Zfish  1234 ASRHSSSWIDTLRRKKHTNNTGAQNTPPTGDDITTSSQVPPIS 1276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	410/982 (42%)
atp8b2	XP_021322579.1	P-type_ATPase_APLT_Dnf-like	63..1033	CDD:319770	410/982 (42%)