Protein Alignment ATP8A and Atp8b5

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_006538058.1
• Gene: Atp8b5 / 320571
• MGIID: 2444287
• Length: 1195
• Species: Mus musculus
• Alignment Length: 1193
• Identity: 452/1193 - (37%)
• Similarity: 681/1193 - (57%)
• Gaps: 126/1193 - (10%)

  Fly   188 SFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPT---KYGNNRITTAKYSFISFLPAFL 249
            |.::.:|.|....|:            |.||:..|..:..   :|.:|.|.|:||.|.:|||..|
Mouse    20 SAMQERRNEDRQKEE------------EERILQANNRRFNSLFEYPDNSIKTSKYGFFNFLPMNL 72

  Fly   250 FEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDI------------K 302
            ||||:|.:|.:||::..||.:|::|....|||::||:.:||::.:|:.|:|:            |
Mouse    73 FEQFQRLANAYFLILLFLQLVPQISSLAWYTTVIPLIVVLSITGVKDAIDDVVKWLPGLPSLDLK 137

  Fly   303 RHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETAN 367
            |||:|.:||:||:..|.:|....::|..:.||||||:..|....||::|||||||..:.:||||:
Mouse   138 RHRSDQQINNRSVSILVNGRVEEIKWRNVQVGDIIKLENNHPVTADMLLLSSSEPYGLTYIETAD 202

  Fly   368 LDGETNLKIRQALPATAELLETKD-LQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVL 431
            ||||||||::||:..|:.:.:..: |....|.:.|:.||..|.:|:|.|...|. ...|.::::|
Mouse   203 LDGETNLKVKQAISVTSAMEDNLELLSSFNGEVRCDPPNNKLDKFSGTLSYLGN-TYLLNHERLL 266

  Fly   432 QRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCN 496
            .||.::|||.|.:|:|||:||:||||:||..:..||:.:|.|.|..::.:||.|..:|.:..:.:
Mouse   267 LRGCVIRNTDWCYGLVVYTGQDTKLMQNSGRSTFKRTHIDHLMNVLVVWIFMFLGGMCFLLSIGH 331

  Fly   497 LFWTREHSETDWYLGLTDFK---TKSLGYNLLTF---FILYNNLIPISLQVTLELVRFLQAIFIN 555
            ..|  |:|...::.....:|   |.|...:.|.|   ||:.|.::||||.|::|::|...:.:||
Mouse   332 GIW--ENSRGYYFQAFLPWKHYITSSATSSALIFWSYFIVLNTMVPISLYVSVEIIRLGNSYYIN 394

  Fly   556 YDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY------TAE 614
            :|.:|::...|.||.|||:.||||||.|:|:|||||||||:|||.|.||||.|..|      ..|
Mouse   395 WDRKMFYAPKNMPAQARTTTLNEELGQVQYVFSDKTGTLTENVMIFNKCSINGKTYGYSYDDNGE 459

  Fly   615 RTPE---------------------ESQLVQNILGRHETSAVIEEFLELLSVCHTVIPERKENGN 658
            ..|:                     :..||:.:  :.|...|...|| .||:||||:.|.|..|.
Mouse   460 YVPKSPKDKVDFSYNHLADPKFSFYDKTLVEAV--KSEDPLVYLFFL-CLSLCHTVMSEEKVEGE 521

  Fly   659 MIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTP 723
            ::|.|.||||.|||...:.||::|.:|||:.:.:..:|..:.|.:|.:|:|::.|||||:|||||
Mouse   522 LVYQAQSPDEGALVTATRNFGFVFCSRTPETITVIEMGKIRVYRLLAILDFSNERKRMSVIVRTP 586

  Fly   724 ENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFD 788
            |:::.||||||||:|||.|.|...:..|.|:.||::|||:|||||.:|..::....:|.|.:...
Mouse   587 EDRVMLFCKGADTIIYELLHPSCASLSEVTMDHLDDFASEGLRTLMVAYRELDKAYFQTWIKKHG 651

  Fly   789 KASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETA 853
            :|.:.|:|||.||......||.:|.|||||||||:||.||||||.:|..|.|.||||||||||||
Mouse   652 EAWLTLENRERKLALVYEEIERDLMLLGATAIEDKLQRGVPETIVTLSKAKIKIWVLTGDKQETA 716

  Fly   854 INIGYSCRLISHSMDIIILNE--------ESLDATR-----------EVIHRHYGE-----FKS- 893
            :||.||||:....||.:.:.|        |.|...|           :.|:.:...     |||
Mouse   717 VNIAYSCRIFKDEMDGVFMVEGTDRETVLEELRTARKKMKPESLLESDPINMYLARKPKMPFKSL 781

  Fly   894 SSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTL 958
            ....:.|..|||.|.:|.|||...|..:......:|:.|:|||::|:|||:||::|.:....|||
Mouse   782 DEVANGNYGLVISGYSLAYALEGSLEFELLRTACMCKGVVCCRMTPLQKAQVVDLVKRYKKVVTL 846

  Fly   959 AIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYS 1023
            ||||||||::||:.|::|:|||..||:||..:||:|..||.:|||||||||..:|.|:.|.:.|.
Mouse   847 AIGDGANDISMIKAAHIGVGISNQEGMQATLSSDFSFCQFHFLQRLLLVHGRLSYNRMCKFLSYF 911

  Fly  1024 FYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLY 1088
            ||||....::..|:|.::|:|.|.:::.|.|..||:::|::|...:.||||.......:.||.||
Mouse   912 FYKNFAFTLVHFWYAFFNGFSAQTVYDIWFITFYNLIYTSLPVLGLSLFEKDVNETWSLCYPELY 976

  Fly  1089 KTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPL-AAYTKEVIWSDGK-TSDYLLMGNLVYTYVIV 1151
            :..|:...||.|.|...:.:.:.:|..||::|: ..:..|  .:||| .||:.....||.|.:|.
Mouse   977 EPGQHNLYFNKKEFVKCLLHGIYNSFVLFFVPMGTVFNSE--RNDGKDISDFQSFSLLVQTTLIG 1039

  Fly  1152 TVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFAS--NFRGMDIQLLSTPVFYF 1214
            .:.::..|.|.|||.:.|...|||:.|:|..|::........::.|  ||.|:....||.|..:.
Mouse  1040 VMTMQIALRTTSWTMINHTFTWGSLGLYFCILILLCSDGLCLRYPSIFNFLGVARNSLSQPQIWL 1104

  Fly  1215 CLMLVPITTLL----------------IDVICKLVH----NTVFKTLTEAVRETEIRRSDISEVM 1259
            ||:|..|..::                .|.:...:|    :.:...:...::...:|||..:
Mouse  1105 CLILSTILCMIPLIGYNFLRPLLWPINADKVLNRIHFCLKHPIPTQVQTKIKHPSLRRSAYA--- 1166

  Fly  1260 NEPRSSDSGFGYAL--GKLIRSS 1280
               .|...|||..:  ||.::||
Mouse  1167 ---FSHKQGFGALITSGKTLKSS 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	396/959 (41%)
Atp8b5	XP_006538058.1	P-type_ATPase_APLT_Dnf-like	54..1008	CDD:319770	396/959 (41%)