Protein Alignment ATP8A and Atp8b3

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_001419373.1
• Gene: Atp8b3 / 299616
• RGDID: 1307622
• Length: 1340
• Species: Rattus norvegicus
• Alignment Length: 1253
• Identity: 457/1253 - (36%)
• Similarity: 680/1253 - (54%)
• Gaps: 173/1253 - (13%)

  Fly   228 KYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVS 292
            ||.:|.|.||||:..||||..|:|||||.||.:||.|.|||.|||:|....:|...||:.:|.:.
  Rat    44 KYKSNAIHTAKYNVFSFLPLNLYEQFRRVSNLYFLFIIILQSIPEISTLPWFTLFAPLVCLLMIR 108

  Fly   293 AIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEP 357
            |.:::::||.|||:|..||:|..:.|...|:...:|..|.|||::.:..:...||||:||:|:||
  Rat   109 AARDLVDDIGRHRSDRIINNRPCQILKGKSFLWKKWKNLCVGDVVCLSKDNIVPADLLLLASTEP 173

  Fly   358 QAMCFIETANLDGETNLKIRQALPAT-AELLETKDLQRLEGRIECELPNRHLYEFNGVLR-ETGK 420
            .::|::|||::|||||||.||||..| .||...|.:...:|.:.||.||..::.|.|.|. .:.|
  Rat   174 SSLCYLETADIDGETNLKFRQALMVTHHELTSPKKMASFQGIVTCEEPNSRMHHFVGSLEWNSRK 238

  Fly   421 PPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMIL 485
            .|..:||  :|.||..:|||...:|:|:|:|.:||:|||.....|||:.:|.:.|..::::||.|
  Rat   239 YPLDIGN--LLLRGCKIRNTDTCYGLVIYAGLDTKIMKNCGKIHLKRTKLDLMMNKLVILIFMSL 301

  Fly   486 ISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLG--YNLLTFFILYNNLIPISLQVTLELVRF 548
            :...:...|...|..:|......|:.....:|.::.  :....|.||.:.::|:::.:..|.:..
  Rat   302 VIASMFLTLGFAFMVKEFKAKHHYMSSMQGRTDAMDSFFIFWGFLILLSVMVPMAMFIIAEFIYL 366

  Fly   549 LQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTA 613
            ..:||||:|:.||:|..:.||.||:::||:.||.|:|||||||||||||:|.||||.|.|..|.:
  Rat   367 GNSIFINWDLSMYYEPLDIPAKARSTSLNDHLGQVQYIFSDKTGTLTQNIMTFKKCCINGCTYDS 431

  Fly   614 E--------RTP-------------EESQLVQNILGRHETSAVIEEFLELLSVCHTVIPERKENG 657
            :        |.|             ...:|...:.|:.:.:  ::||..||::||||:.:.|:|
  Rat   432 DDEHGTLRKRNPYSWNPFADGKLQFYNKELESLVRGKQDRA--VQEFWRLLAICHTVMVQEKDN- 493

  Fly   658 NMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRT 722
            .::|.||||||.|||..|:.|||:|.:||...:.:..||..:.|:||.:::|.|.|||||::||.
  Rat   494 QLLYQAASPDEEALVAAARNFGYVFLSRTQDTITLVELGEERVYQVLAMMDFNSVRKRMSVLVRN 558

  Fly   723 PENKIKLFCKGADTVIYERLAPQG--QAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQ 785
            ||..|.|:.|||||||.|||..:|  :|..|:.   |..||...|||||||..|:..|.|:||..
  Rat   559 PEGSICLYTKGADTVILERLHHKGVMEATTEEV---LAAFAEQTLRTLCLAYKDVAEDAYKEWEP 620

  Fly   786 TFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQ 850
            ...:|::.||||...|....|.:|.||:|||.|||||:|||||||||..|....|.:|||||||.
  Rat   621 EHQEAALLLQNRAQALHQVYNKLEQNLQLLGVTAIEDKLQDGVPETIRCLKKGNIKMWVLTGDKP 685

  Fly   851 ETAINIGYSCRLISHSMDI--------------------------------IILNEESLD----- 878
            |||:|||::|:|:|.:|.|                                :::|.|.||
  Rat   686 ETAVNIGFACQLLSENMSILEDKDIKGLLENYWDENEHQRAFQTMTHHNMALVINGEFLDQLLLS 750

  Fly   879 ----------------ATRE---------------VIHRHYGEFKSSSAKDANVALVIDGTTLKY 912
                            ||:|               .:.|::|...::|..||:          |.
  Rat   751 LRKEPRALVQNAVVDEATQEPGVSALDFLQARRISQMWRNFGTTMATSQSDAS----------KT 805

  Fly   913 ALSCDLRND--FQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANV 975
            ..|.:.|.:  |.||...|:.||||||:|.|||.||.:|.:....||||||||||||.||:.|::
  Rat   806 RESPEERRERAFVDLASKCQAVICCRVTPKQKALVVALVKKYQQVVTLAIGDGANDVNMIKTADI 870

  Fly   976 GIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVY 1040
            |:|::|.||:||...|||.:|||.||||||||||.|:|.||.|.:.|.|||.|...:.::||:::
  Rat   871 GVGLAGQEGMQAVQNSDYVLAQFCYLQRLLLVHGRWSYMRICKFLRYFFYKTVASMMAQIWFSLF 935

  Fly  1041 SGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIW 1105
            :|:|.|.|:|.|.:.|:|:|::.:|...:||||:..|||..::.|.||...|..:|||..:|...
  Rat   936 NGFSAQPLYEGWFLALFNLLYSTLPVLYIGLFEQDVTAEKSLKMPELYTAGQKDELFNYSIFVQA 1000

  Fly  1106 IFNALLHSVFLFWLP-LAAY--TKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWL 1167
            |.:..:.|:..|::. |.:|  ||     .|.:.||...|.||....::::.|:..|:...||
  Rat  1001 IAHGTITSLINFFVTILVSYDMTK-----TGSSPDYQSFGVLVAISSLLSITLEVILVVKYWT-- 1058

  Fly  1168 THLAIWGSIVLWFGFLLIYSHVWP---MFKFASN---FRGMDIQLLSTPVFYFCLML-VPITTLL 1225
              |...|::|:.....:|::.:..   :|:.:..   |...|..::..|.....::| |.:.||.
  Rat  1059 --LLFVGTVVVSLSSYVIFTSLTESLLLFRISPKTFPFLFADYNVIREPSSLLVIVLNVTLNTLP 1121

  Fly  1226 IDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEP----------RSSDSGF----GYALGKL 1276
            : :..:::..||.|  ....:|.|:...:::.   ||          |.|...|    |||  .|
  Rat  1122 M-LAVRIIRRTVLK--RHPKKEEEVPSEELTV---EPAMRLRRGMPARRSSYAFSHHEGYA--NL 1178

  Fly  1277 IRSSHILISHDHHPVSESSRTSNLRVENLEMEADTEQQQQS------------RQRQKWRGGQVA 1329
            |....||..|.|  |.|....:.....|...|....|.::|            ::||.:  |:.:
  Rat  1179 ITQGTILRRHTH--VDEFYGDTACNSPNPSEEDVPWQHKESIFNPRKISILAKKRRQHY--GKGS 1239

  Fly  1330 TG-VARSARNSTTSPITA 1346
            .| |..:|.:.||...||
  Rat  1240 QGEVHPNASSQTTEKQTA 1257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	394/985 (40%)
Atp8b3	NP_001419373.1	P-type_ATPase_APLT_Dnf-like	47..1015	CDD:319770	394/985 (40%)