DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8A and Atp8b1

DIOPT Version :9

Sequence 1:NP_001137651.1 Gene:ATP8A / 36488 FlyBaseID:FBgn0259221 Length:1350 Species:Drosophila melanogaster
Sequence 2:NP_001099610.1 Gene:Atp8b1 / 291555 RGDID:1308488 Length:1259 Species:Rattus norvegicus


Alignment Length:1162 Identity:466/1162 - (40%)
Similarity:677/1162 - (58%) Gaps:125/1162 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 TKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSV 291
            :||.:|.|.|.||:.::|||..|||||:|.:|.:||::.|||.||::|....|||||||:.:|.:
  Rat    90 SKYASNAIKTYKYNALTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLLVLGI 154

  Fly   292 SAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSE 356
            :|||::::|:.||:.|.|||:|:.|.:..|.:..::|.::.|||:|::..|.|.|||::||||||
  Rat   155 TAIKDLVDDVARHKMDKEINNRTCEVIKDGRFKIIKWKDIQVGDVIRLKKNDFIPADILLLSSSE 219

  Fly   357 PQAMCFIETANLDGETNLKIRQALPATAELLETKD-LQRLEGRIECELPNRHLYEFNGVL--RET 418
            |.::|::|||.||||||||.:.||..|.:.|:.:| |...:|.||||.||..|.:|.|.|  |..
  Rat   220 PNSLCYVETAELDGETNLKFKMALEITDQYLQIEDNLATFDGFIECEEPNNRLDKFTGTLFWRNQ 284

  Fly   419 GKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFM 483
            ..|   |..|::|.||.::|||....|:|:::|.:||:||||.....||:.:|.|.|   .|::.
  Rat   285 SFP---LDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMN---YMVYT 343

  Fly   484 ILISLCIIS-GLC--NLFWTREHSETDWYLGLTDFKTKSL-GY-NLLTFFILYNNLIPISLQVTL 543
            |:|.|.::| ||.  :.:|..:.....|||...:..|.|. |: |...:.|:.|.::||||.|::
  Rat   344 IIIVLILVSAGLAIGHAYWEAQIGNYSWYLYDGENATPSYRGFLNFWGYIIVLNTMVPISLYVSV 408

  Fly   544 ELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAG 608
            |::|..|:.|||:|::||:.|.:|||.:||:.|||:||.:.|||||||||||||:|.||||.|.|
  Rat   409 EVIRLGQSHFINWDLQMYYAEKDTPAKSRTTTLNEQLGQIHYIFSDKTGTLTQNIMTFKKCCING 473

  Fly   609 YVYTAERTPEESQ-------------------------LVQNILGRHETSAVIEEFLELLSVCHT 648
            .:|...|...:..                         |::.|....|..  :.:|..|||:|||
  Rat   474 TIYGDHRDASQHSHSKIELVDFSWNEFADGKLAFYDHYLIEQIQSGKEPE--VRQFFFLLSICHT 536

  Fly   649 VIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSR 713
            |:.:|.: |.:.|.||||||.|||..|:.||:.|..||...:.::.||..:.|.||.:|:|.|.|
  Rat   537 VMVDRID-GQINYQAASPDEGALVNAARNFGFAFLARTQNTITVSELGTERTYSVLAILDFNSDR 600

  Fly   714 KRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPD 778
            ||||:||||||..|:|:|||||||||||| .:....:::|...|:.|||:.||||||...:|...
  Rat   601 KRMSIIVRTPEGSIRLYCKGADTVIYERL-HRMNPMKQETQDALDIFASETLRTLCLCYKEIEEK 664

  Fly   779 VYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIW 843
            .:.||::.|..||||..||:..|:.....||.:|.|||||||||:|||||||||:.|..|.|.||
  Rat   665 EFAEWNKKFMAASVASSNRDEALDKVYEEIERDLILLGATAIEDKLQDGVPETISKLAKADIKIW 729

  Fly   844 VLTGDKQETAINIGYSCRLISHSMDIIILNEESLDA---TREVIHRHYGEFKSSSAKDA------ 899
            ||||||:|||.|||::|.|::.  |..|...|.:::   ||....|:.|...:..|..|      
  Rat   730 VLTGDKKETAENIGFACELLTE--DTTICYGEDINSLLHTRMENQRNRGGVSAKFAPPAYEPFFP 792

  Fly   900 ---NVALVIDGT-----------------TLKYALSCDLR------------------NDFQDLC 926
               |.||:|.|:                 .||:..:.:.|                  .:|.||.
  Rat   793 PGENRALIITGSWLNEILLEKKTKRSKILKLKFPRTEEERRMRSQSRRRLEEKKEQRQKNFVDLA 857

  Fly   927 ILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACAS 991
            ..|..||||||:|.|||.||::|.:...|:|||||||||||.||:.|::|:||||.||:||..:|
  Rat   858 CECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSS 922

  Fly   992 DYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGL 1056
            |||.||||||||||||||.|:|.|:.|.:.|.||||....::..|::.::|:|.|..:|.|.|.|
  Rat   923 DYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDWFITL 987

  Fly  1057 YNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPL 1121
            ||||::::|...|||.::..:.:..:|:|.||...|...|||.|.|::.:.:.:|.|:.||::|.
  Rat   988 YNVLYSSLPVLLMGLLDQDVSDKLSLRFPGLYVVGQRDLLFNYKKFFVSLLHGVLTSMVLFFIPF 1052

  Fly  1122 AAYTKEVIWSDGKT-SDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLI 1185
            .||. :.:..||:. |||......:.:.:::||..:.||.|:.||::...:|:|||.|:||.:..
  Rat  1053 GAYL-QTVGQDGEAPSDYQSFAVTMASALVITVNFQIGLDTSYWTFVNAFSIFGSIALYFGIMFD 1116

  Fly  1186 YS----HVWPMFKFASNFRGMDI--------QLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVF 1238
            :.    ||  :|..|..|.|...        ..|..|..:..::|.....||..|..:.:..|::
  Rat  1117 FHSAGIHV--LFPSAFQFTGWCFSDSESTASNALRQPYIWLTIILTVAVCLLPVVAIRFLSMTIW 1179

  Fly  1239 KTLTEAVR---------ETEIRRSDISEVMNEPRSSDSGF----GYA----LGKLIR 1278
            .:.::.::         |...||..:.......|.|...|    |||    .|:.||
  Rat  1180 PSESDKIQKHRKRLKAEEQWKRRQSVFRRGASSRRSAYAFSHQRGYADLISSGRSIR 1236

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8ANP_001137651.1 PhoLip_ATPase_N 218..280 CDD:292826 25/52 (48%)
ATPase-Plipid 229..1247 CDD:273734 453/1119 (40%)
E1-E2_ATPase 286..>371 CDD:278548 37/84 (44%)
Cation_ATPase 645..741 CDD:289987 52/95 (55%)
HAD_like <942..1001 CDD:304363 37/58 (64%)
PhoLip_ATPase_C 988..1240 CDD:292829 92/264 (35%)
Atp8b1NP_001099610.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52
PhoLip_ATPase_N 86..142 CDD:292826 25/51 (49%)
ATPase-Plipid 92..1187 CDD:273734 453/1109 (41%)
E1-E2_ATPase 171..>234 CDD:278548 29/62 (47%)
Cation_ATPase 534..628 CDD:289987 52/94 (55%)
HAD_like <875..919 CDD:304363 26/43 (60%)
PhoLip_ATPase_C 919..1181 CDD:292829 92/264 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X168
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.730

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