Protein Alignment ATP8A and Atp8a1

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_038948654.1
• Gene: Atp8a1 / 289615
• RGDID: 1309619
• Length: 1209
• Species: Rattus norvegicus
• Alignment Length: 1144
• Identity: 637/1144 - (55%)
• Similarity: 821/1144 - (71%)
• Gaps: 41/1144 - (3%)

  Fly   184 RMTASFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAF 248
            |:|.:...||...||..:|.:..... ||..|.|.|.:|.||.||:.||.::||||:.|:|||.|
  Rat    50 RLTHNQRARKPPGYEKTDDVSEKTSL-ADQEEVRTIFINQPQLTKFCNNHVSTAKYNVITFLPRF 113

  Fly   249 LFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHR 313
            |:.||||.:|.|||.||:|||||:|||||||||||||:|||:|:||||||||||||:|||.:|.:
  Rat   114 LYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKK 178

  Fly   314 SIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQ 378
            ..:.|.:|:|..|.|.::.||||:.:....|.|||.:|||||||||||:|||:||||||||||||
  Rat   179 QTQVLRNGAWEIVHWEKVNVGDIVIIKGKEFIPADTVLLSSSEPQAMCYIETSNLDGETNLKIRQ 243

  Fly   379 ALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWV 443
            .||||:::.:...|.|:.||||||.||||||:|.|.:|..|.....||.||:|.|||.||||.||
  Rat   244 GLPATSDIKDIDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWV 308

  Fly   444 FGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDW 508
            .|||||:|.:||||:||||.|||.|.|:::||.|||:||.|||::.::..:.:..|.|.||..||
  Rat   309 HGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDW 373

  Fly   509 YLGLTDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMART 573
            ||.|......:.|.|.|||.||:||||||||.||||:|:|.||.|||:|::|::|.::|.|||||
  Rat   374 YLHLHYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMART 438

  Fly   574 SNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY---------------------TAERTP 617
            ||||||||.|||||||||||||.|||:||||:|||..|                     ..|:|.
  Rat   439 SNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQSSQFGDEKTF 503

  Fly   618 EESQLVQNILGRHETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIF 682
            .:..|::|:...|.|:.:|.|||.:::||||.:||| :...:||.||||||.|||..|::..::|
  Rat   504 NDPSLLENLQNNHPTAPIICEFLTMMAVCHTAVPER-DGEKIIYQAASPDEGALVRAAKQLNFVF 567

  Fly   683 DTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQ 747
            ..|||..|.|::||..:|||:||||||||||||||::||||..|::|:||||||||||||| :..
  Rat   568 TGRTPDSVIIDSLGQEERYELLNVLEFTSSRKRMSVVVRTPSGKLRLYCKGADTVIYERLA-ESS 631

  Fly   748 AFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNL 812
            .::|.||:|||:||::||||||.|||:|....::||...:.:||.::|||..|||::..|||.||
  Rat   632 KYKEITLKHLEQFATEGLRTLCFAVAEISESDFEEWRAVYQRASTSVQNRLLKLEESYELIEKNL 696

  Fly   813 RLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESL 877
            :|||||||||:|||.|||||.:|:.|.|.||:|||||||||||||:||||:..:|.:|::||.||
  Rat   697 QLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCRLLRRNMGMIVINEGSL 761

  Fly   878 DATREVIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQK 942
            |.|||.:.||......:..|:.:.||:|||.||||||:..:|..|.||.:.|:.||||||||:||
  Rat   762 DGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQK 826

  Fly   943 AEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLV 1007
            :||||||.:....:|||||||||||:|||.|:||:||||.||||||.:||||||||:||:.||:|
  Rat   827 SEVVEMVKKQVKVITLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMV 891

  Fly  1008 HGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLF 1072
            ||||||.|:||.|||.||||:.||:||:|||..:|:|||||||||.||||||:||||||..:|:|
  Rat   892 HGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIF 956

  Fly  1073 EKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSD 1137
            |:.|..|.|::||.||||||||..||.||||:...|.|.|||.|||.||.|.....::.:|||||
  Rat   957 ERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTVFGNGKTSD 1021

  Fly  1138 YLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGM 1202
            |||:||.|||:|::||||||||.|:.|||.:|:||||||.||..|..|||.:||....|.:..|.
  Rat  1022 YLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAVPMAPDMSGE 1086

  Fly  1203 DIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRSSDS 1267
            ...|.|:.||:..|:.:|:.:||:||:.|::..|.||||.:.|:|.|.:..|...|:
  Rat  1087 AAMLFSSGVFWVGLLSIPVASLLLDVLYKVIKRTAFKTLVDEVQELEAKSQDPGAVV-------- 1143

  Fly  1268 GFGYALGKLIRSSHILISHDHHPVSESSRTSNLRVENLE 1306
                 |||.:.....|:.:    |.:.:..:..|.|:|:
  Rat  1144 -----LGKSLTERAQLLKN----VFKKNHVNLYRSESLQ 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	545/909 (60%)
Atp8a1	XP_038948654.1	ATPase-Plipid	94..1131	CDD:273734	608/1038 (59%)