DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and Atp8a1

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	XP_038948654.1	Gene:	Atp8a1 / 289615	RGDID:	1309619	Length:	1209	Species:	Rattus norvegicus

Alignment Length:	1144	Identity:	637/1144 - (55%)
Similarity:	821/1144 - (71%)	Gaps:	41/1144 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 RMTASFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAF 248
            |:|.:...||...||..:|.:..... ||..|.|.|.:|.||.||:.||.::||||:.|:|||.|
  Rat    50 RLTHNQRARKPPGYEKTDDVSEKTSL-ADQEEVRTIFINQPQLTKFCNNHVSTAKYNVITFLPRF 113

  Fly   249 LFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHR 313
            |:.||||.:|.|||.||:|||||:|||||||||||||:|||:|:||||||||||||:|||.:|.:
  Rat   114 LYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKK 178

  Fly   314 SIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQ 378
            ..:.|.:|:|..|.|.::.||||:.:....|.|||.:|||||||||||:|||:||||||||||||
  Rat   179 QTQVLRNGAWEIVHWEKVNVGDIVIIKGKEFIPADTVLLSSSEPQAMCYIETSNLDGETNLKIRQ 243

  Fly   379 ALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWV 443
            .||||:::.:...|.|:.||||||.||||||:|.|.:|..|.....||.||:|.|||.||||.||
  Rat   244 GLPATSDIKDIDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWV 308

  Fly   444 FGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDW 508
            .|||||:|.:||||:||||.|||.|.|:::||.|||:||.|||::.::..:.:..|.|.||..||
  Rat   309 HGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDW 373

  Fly   509 YLGLTDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMART 573
            ||.|......:.|.|.|||.||:||||||||.||||:|:|.||.|||:|::|::|.::|.|||||
  Rat   374 YLHLHYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMART 438

  Fly   574 SNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY---------------------TAERTP 617
            ||||||||.|||||||||||||.|||:||||:|||..|                     ..|:|.
  Rat   439 SNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQSSQFGDEKTF 503

  Fly   618 EESQLVQNILGRHETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIF 682
            .:..|::|:...|.|:.:|.|||.:::||||.:||| :...:||.||||||.|||..|::..::|
  Rat   504 NDPSLLENLQNNHPTAPIICEFLTMMAVCHTAVPER-DGEKIIYQAASPDEGALVRAAKQLNFVF 567

  Fly   683 DTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQ 747
            ..|||..|.|::||..:|||:||||||||||||||::||||..|::|:||||||||||||| :..
  Rat   568 TGRTPDSVIIDSLGQEERYELLNVLEFTSSRKRMSVVVRTPSGKLRLYCKGADTVIYERLA-ESS 631

  Fly   748 AFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNL 812
            .::|.||:|||:||::||||||.|||:|....::||...:.:||.::|||..|||::..|||.||
  Rat   632 KYKEITLKHLEQFATEGLRTLCFAVAEISESDFEEWRAVYQRASTSVQNRLLKLEESYELIEKNL 696

  Fly   813 RLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESL 877
            :|||||||||:|||.|||||.:|:.|.|.||:|||||||||||||:||||:..:|.:|::||.||
  Rat   697 QLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCRLLRRNMGMIVINEGSL 761

  Fly   878 DATREVIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQK 942
            |.|||.:.||......:..|:.:.||:|||.||||||:..:|..|.||.:.|:.||||||||:||
  Rat   762 DGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQK 826

  Fly   943 AEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLV 1007
            :||||||.:....:|||||||||||:|||.|:||:||||.||||||.:||||||||:||:.||:|
  Rat   827 SEVVEMVKKQVKVITLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMV 891

  Fly  1008 HGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLF 1072
            ||||||.|:||.|||.||||:.||:||:|||..:|:|||||||||.||||||:||||||..:|:|
  Rat   892 HGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIF 956

  Fly  1073 EKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSD 1137
            |:.|..|.|::||.||||||||..||.||||:...|.|.|||.|||.||.|.....::.:|||||
  Rat   957 ERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTVFGNGKTSD 1021

  Fly  1138 YLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGM 1202
            |||:||.|||:|::||||||||.|:.|||.:|:||||||.||..|..|||.:||....|.:..|.
  Rat  1022 YLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAVPMAPDMSGE 1086

  Fly  1203 DIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRSSDS 1267
            ...|.|:.||:..|:.:|:.:||:||:.|::..|.||||.:.|:|.|.:..|...|:
  Rat  1087 AAMLFSSGVFWVGLLSIPVASLLLDVLYKVIKRTAFKTLVDEVQELEAKSQDPGAVV-------- 1143

  Fly  1268 GFGYALGKLIRSSHILISHDHHPVSESSRTSNLRVENLE 1306
                 |||.:.....|:.:    |.:.:..:..|.|:|:
  Rat  1144 -----LGKSLTERAQLLKN----VFKKNHVNLYRSESLQ 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	39/61 (64%)
		ATPase-Plipid	229..1247	CDD:273734	608/1038 (59%)
		E1-E2_ATPase	286..>371	CDD:278548	50/84 (60%)
		Cation_ATPase	645..741	CDD:289987	59/95 (62%)
		HAD_like	<942..1001	CDD:304363	42/58 (72%)
		PhoLip_ATPase_C	988..1240	CDD:292829	148/251 (59%)
Atp8a1	XP_038948654.1	ATPase-Plipid	94..1131	CDD:273734	608/1038 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	344	1.000	Domainoid score	I1021
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48402
Inparanoid	1	1.050	1221	1.000	Inparanoid score	I174
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm44774
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980