Protein Alignment ATP8A and ATP11C

DIOPT Version :9

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_016884928.1
• Gene: ATP11C / 286410
• HGNCID: 13554
• Length: 1152
• Species: Homo sapiens
• Alignment Length: 1155
• Identity: 402/1155 - (34%)
• Similarity: 625/1155 - (54%)
• Gaps: 132/1155 - (11%)

  Fly   207 AGYDADDGERRIINLNGPQ-------PTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLI 264
            ||.:...|.|.:...|.|.       ..::.:|||.::||:..:|||..|||||||.:|.:||:|
Human    14 AGEEKRVGTRTVFVGNHPVSETEAYIAQRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLII 78

  Fly   265 AILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWS 329
             .|.|:...:||...|:.:||.|:::|:|||:..||..|||||||:|..::..:::.........
Human    79 -FLVQVTVDTPTSPVTSGLPLFFVITVTAIKQGYEDCLRHRADNEVNKSTVYIIENAKRVRKESE 142

  Fly   330 ELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQR 394
            ::.|||:::|..:..||.|||||||......|::.||:||||:|.|...|:..|..|...:.:..
Human   143 KIKVGDVVEVQADETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTAESIDT 207

  Fly   395 LEGRIECELPNRHLYE---------------------------FNGVLRETGKPPAALGNDQVLQ 432
            |...||||.|...||:                           ::..|....:   :||.:.:|.
Human   208 LRAAIECEQPQPDLYKKMNQISLVHYQPRINHCGPRFVGRINIYSNSLEAVAR---SLGPENLLL 269

  Fly   433 RGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNT-QILMLFMILISLCIISGLCN 496
            :||.|:||..::|:.||:|.|||:..|......|||.|:|..|. .|:.||::|....:.:.|..
Human   270 KGATLKNTEKIYGVAVYTGMETKMALNYQGKSQKRSAVEKSINAFLIVYLFILLTKAAVCTTLKY 334

  Fly   497 LFWTREHSETDWYLGLTD-----FKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINY 556
            ::.:..:::..||...|.     .|...:..:.|:|.:|:|.:||:|:.||:|:.:||.:.||::
Human   335 VWQSTPYNDEPWYNQKTQKERETLKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISW 399

  Fly   557 DIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERTPEESQ 621
            |.:.|.||.|..|:..||:||||||.|.|:|:|||||||:|.|||.:|.|.|:.|..
Human   400 DKDFYDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKG-------- 456

  Fly   622 LVQNILGRHETSAVI-----------EEFLELLSVCHTV-------IPERKENGNMIYHAASPDE 668
            :.|.:.|..:|...:           |.||..|.:||||       :....|:..:.|.::||||
Human   457 VTQEVDGLSQTDGTLTYFDKVDKNREELFLRALCLCHTVEIKTNDAVDGATESAELTYISSSPDE 521

  Fly   669 RALVEGAQKFGYIFDTRTPKYVEI-NALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCK 732
            .|||:||:::|:.|......|:.: |.....:.||:|:.|.|.:.|:|||:||:|.|..|.||||
Human   522 IALVKGAKRYGFTFLGNRNGYMRVENQRKEIEEYELLHTLNFDAVRRRMSVIVKTQEGDILLFCK 586

  Fly   733 GADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNR 797
            |||:.::.|:  |.... |.|..|:|..|.||.||||:|..:|.||.|:..::...:|.:|||:|
Human   587 GADSAVFPRV--QNHEI-ELTKVHVERNAMDGYRTLCVAFKEIAPDDYERINRQLIEAKMALQDR 648

  Fly   798 ESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRL 862
            |.|:|...:.||.|:.|:||||:||:|||...|||.:|..||:.:|||||||.|||.:..|:|||
Human   649 EEKMEKVFDDIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRL 713

  Fly   863 ISHSMDIIILN----EES-----------LDATREVIH---RHYGEFKSSSAKDANVALVIDGTT 909
            ...:.:::.|.    |||           ::..::::|   :....||.:..:.....|:|||:|
Human   714 FQTNTELLELTTKTIEESERKEDRLHELLIEYRKKLLHEFPKSTRSFKKAWTEHQEYGLIIDGST 778

  Fly   910 LKYAL-------SCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQ-STNAVTLAIGDGAND 966
            |...|       |.:.::.|..:|:.|..|:|||::|:|||::|.||.. ..:.:||:|||||||
Human   779 LSLILNSSQDSSSNNYKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPITLSIGDGAND 843

  Fly   967 VAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLY 1031
            |:||.:::|||||.|.||.|||..||||:.:|::|::|||.||...|.||:.|:.|.||||:|..
Human   844 VSMILESHVGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFI 908

  Fly  1032 VIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLY-KTSQNAK 1095
            :.:..:..:.|:|.|.|::...:.:||:.||::|..|..|.|:....:|:...|.|| |.|.||.
Human   909 LPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDTLTSDPRLYMKISGNAM 973

  Fly  1096 LFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLI 1160
            | .:..|..|.|.|.......|:.....:....:..:||.......|.:|:|.::.||.||..|.
Human   974 L-QLGPFLYWTFLAAFEGTVFFFGTYFLFQTASLEENGKVYGNWTFGTIVFTVLVFTVTLKLALD 1037

  Fly  1161 TNSWTWLTHLAIWGSIVLWFGFLLIYSH-VWPMFK-------FASNFRGMDIQLLSTPVFYFCLM 1217
            |..|||:.|..||||:..:..|...:.. :||..|       ||        |:||:...:..::
Human  1038 TRFWTWINHFVIWGSLAFYVFFSFFWGGIIWPFLKQQRMYFVFA--------QMLSSVSTWLAII 1094

  Fly  1218 LVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRSSDS 1267
            |:...:|..:::..::.|         ||....||:     ::..|:|||
Human  1095 LLIFISLFPEILLIVLKN---------VRRRSARRN-----LSCRRASDS 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	25/68 (37%)
		ATPase-Plipid	229..1247	CDD:273734	389/1104 (35%)
		E1-E2_ATPase	286..>371	CDD:278548	33/84 (39%)
		Cation_ATPase	645..741	CDD:289987	40/103 (39%)
		HAD_like	<942..1001	CDD:304363	33/59 (56%)
		PhoLip_ATPase_C	988..1240	CDD:292829	79/260 (30%)
ATP11C	XP_016884928.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720