DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and CG33298

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1531	Identity:	446/1531 - (29%)
Similarity:	684/1531 - (44%)	Gaps:	382/1531 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RRQQRIAQQRQDSWFRHSMPPAINRDFESLEHLTPRASDGLDEQLAASVSHSVHS------GGSV 97
            ||:..:.||::      |.||.:..|         ..|.|:....|:|.:.|:..      ||..
  Fly    10 RRKFLVVQQQR------SAPPNLTGD---------TLSSGIPNASASSATTSLMMTTSTGLGGVA 59

  Fly    98 TLCGPPDHSSI------------------------------HLNSANSNLGFIDSDTPNTPVTPV 132
            ...|.|:.:.:                              |..|.:...|.|.........:.:
  Fly    60 MGAGEPERTYVFPGGNPVVGSAPGGGGQGIPGVAMAAPSRGHARSISHGGGAIVGANGRPIKSAM 124

  Fly   133 SGLQPPAS---VSTSVGGTLSSRRRSSNRKDSKGSIL-------------------------SRQ 169
            .|.|...|   ::.|..|:.:...|..:|..||...:                         |||
  Fly   125 KGHQRAFSQGQITDSPPGSAAPAGRGHSRVGSKTDFILPPGHKEEPAREPSAPTSATGGRGHSRQ 189

  Fly   170 SGKSRVSLLAQRGLRMTASFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTK------ 228
            :.:|. |:...|.......:.|.....|...:.|        ::...|.:..|...|.|
  Fly   190 ASRSE-SIYTLRRTEAPPWWKRLTLCNYNTGDKF--------EERSYRTVVPNHTVPPKTPKRDH 245

  Fly   229 ----YGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFIL 289
                :..|:|.|.||:.:||:|..|.|||.|.:|.:|:.|.:|..:||:|..|:...::|::|:|
  Fly   246 PNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVL 310

  Fly   290 SVSAIKEIIEDIKRHRADNEINHRSIERLDSGS--WCTVRWSELTVGDIIKVGINTFFPADLILL 352
            .|:|:|::.||.:|..:|..||:.:....|..:  :..|:|.||.||||:.:..|...|||::||
  Fly   311 GVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLL 375

  Fly   353 SSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRE 417
            .:|:||.:|:|:|.:||||||||.|:.:....|:.......:...|:|.:.|...||.|:|.|..
  Fly   376 RTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIH 440

  Fly   418 TGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLF 482
            .......:..:.:|.|.:.|:||.::.|||||:|.|||.|.|::....|||.|::..|..::...
  Fly   441 PTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCV 505

  Fly   483 MILISLCIISGL-CNLFWTREHSETDWYLGLTDFKTKSLGYNLL-----------TFFILYNNLI 535
            :||:.||::..: |.:          |....|.|....|..|.|           |:.::...:|
  Fly   506 IILLILCVVGAIGCRM----------WLSSFTHFPVPYLPPNKLTANMESMWIFWTYIVILQVMI 560

  Fly   536 PISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVME 600
            |:||.||:||.:.||...|:.:::::..|:|.....|..|:.||||.:::||:|||||||:|.|.
  Fly   561 PLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMI 625

  Fly   601 FKKCSIAG-----------YVYTAERTPE---------ESQLVQNILGRHET--SAVIEEFLELL 643
            |::|.:.|           .:|:....|.         .|.:.|...|.:.|  :..|:|||.:|
  Fly   626 FRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVL 690

  Fly   644 SVCHTVI---------------------------------------------------------P 651
            ::|:|||                                                         |
  Fly   691 AICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQP 755

  Fly   652 E---------------------------------------------------------------- 652
            :
  Fly   756 QVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNK 820

  Fly   653 -----------------------------------------------RKENGNMIYHAASPDERA 670
                                                           |..:|..:|.|.||||.|
  Fly   821 SLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELA 885

  Fly   671 LVEGAQKFGYIFDTRTPKYVEIN--ALGVRKRYEVLNVLEFTSSRKRMSLIVR-TPENKIKLFCK 732
            ||..|..:......|:|..:.::  ..|..:.||:|.||.|.||||.||::|| ....:|.|:.|
  Fly   886 LVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTK 950

  Fly   733 GADTVIYERL------APQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKAS 791
            |||:.|...|      :|:| ..||||.:.|:.:|.:|||.|.:|...:....|.:|.....:..
  Fly   951 GADSSIMPVLVPCSHNSPEG-ILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIE 1014

  Fly   792 VALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINI 856
            ::|:|||.:|.|:...:|:||.|||||.|||||||||||||||||.|||.:|||||||.||||||
  Fly  1015 MSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINI 1079

  Fly   857 GYSCRLISHSMDIIILNEESLDATREVIHRH--------------YGEFKSSSAKDANVALVIDG 907
            .||.:|.:..|::|.|...|.||....|:.:              ||:    |.:....|||:||
  Fly  1080 AYSAKLFTQQMELIRLTARSRDAAETAINFYLTDMENDKTTSTLGYGQ----SLRKKQRALVVDG 1140

  Fly   908 TTLKYAL--SCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMI 970
            .||.:.|  ...|...|..|...|..|:|||.:|:|||.:|::|.:..|..|||||||||||:||
  Fly  1141 KTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMI 1205

  Fly   971 QKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIEL 1035
            |.|:||:||||.||:||..|:|:::.:||||:||||.||.|.|.|:|::|||.||||.....:..
  Fly  1206 QMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIF 1270

  Fly  1036 WFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVK 1100
            |:.:|.|:|||::.::..:.|||::||::||.|:|:::|....:.:::.|.|||..:....:...
  Fly  1271 WYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPH 1335

  Fly  1101 VFWIWIFNALLHSVFLFWLPLAAYTKE--VIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLI--- 1160
            .||:.:.:||..|:.:|::.|.||.:.  .||..|.|              |...||.|.|:
  Fly  1336 DFWLILLDALYQSLVIFFVALCAYAESDVGIWEFGTT--------------ITASCLFANLVHCA 1386

  Fly  1161 --TNSWTWLTHLAIWGSIVLWFGFLLIYSHV-----------WPMFK-FASNFRGMDIQLLSTPV 1211
              ..|||.|..|:|..|:..::.|.::|..|           |.:|. |||....:.| :|||.|
  Fly  1387 IEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVI-MLSTVV 1450

  Fly  1212 FYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRE 1247
            .....:|  :||:.|    .|..:...|.:.::.||
  Fly  1451 AVLPRLL--LTTVRI----SLCPDDSTKVILQSKRE 1480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	24/71 (34%)
		ATPase-Plipid	229..1247	CDD:273734	401/1265 (32%)
		E1-E2_ATPase	286..>371	CDD:278548	34/86 (40%)
		Cation_ATPase	645..741	CDD:289987	41/266 (15%)
		HAD_like	<942..1001	CDD:304363	34/58 (59%)
		PhoLip_ATPase_C	988..1240	CDD:292829	86/270 (32%)
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	20/49 (41%)
		ATPase-Plipid	250..1473	CDD:273734	400/1258 (32%)
		E1-E2_ATPase	302..>394	CDD:278548	35/91 (38%)
		Cation_ATPase	<880..965	CDD:289987	33/84 (39%)
		HAD_like	<1177..1240	CDD:304363	37/62 (60%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	86/265 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11922at33392
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850