DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and SPAC4F10.16c

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_594759.1	Gene:	SPAC4F10.16c / 2543523	PomBaseID:	SPAC4F10.16c	Length:	1367	Species:	Schizosaccharomyces pombe

Alignment Length:	1450	Identity:	459/1450 - (31%)
Similarity:	681/1450 - (46%)	Gaps:	331/1450 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 MPPAINRDFESLEHLTPRASDGLDEQLAASVSHSVHSGGSVTLCGP---PDHSSIHLNS-----A 113
            ||..||  |:::..| ..:..||.......:.|.....||:...||   .|:||.|..|     |
pombe     1 MPSLIN--FDAISSL-KSSLHGLSICAFNHLHHVPQHNGSLAHEGPTNQTDYSSRHHESQFSQEA 62

  Fly   114 NSNLGFIDSDTPNTPVTPVSGLQPPASVSTSVGGTLSSRRRSSNRKDSKGSILSRQSGKSRVSLL 178
            ::.....|.:..|                        |...|.|..|        ||..|||:
pombe    63 HAEQRSRDDEEAN------------------------SFEGSCNNSD--------QSWTSRVT-- 93

  Fly   179 AQRGLRMTASFLRRKRTEYEDDEDFTSSAGYDADDGE-RRIINLNGPQ-----PTK-YGNNRITT 236
                         .|:.|          ||.::.|.. |||...:.|:     |:: :.:|:|.|
pombe    94 -------------SKKNE----------AGTESGDASVRRIYVTSIPEEHRHLPSQWFPSNKIRT 135

  Fly   237 AKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDI 301
            .||:.:||:|..|:.||:..:|.|||.:.:||.||...|.....:.:||..||..:|||:.|||.
pombe   136 TKYTPVSFIPKNLWNQFKNIANAFFLFVTLLQCIPLFCPEHLGLSFIPLSVILLTTAIKDGIEDY 200

  Fly   302 KRHRADNEINH----------------------RSIERLDSG-----SWC--------------- 324
            :|...|.:.|:                      |.:::..|.     |:|
pombe   201 RRCVLDKKFNNTLTWKLVGFNNANALGEHIGLWRKLKKFISHTVADMSYCLKNSGISSGLATLTV 265

  Fly   325 -------------------------------------------------------TVRWSELTVG 334
                                                                   .|....|.||
pombe   266 DNISHRHSLESDSAFTLSSVSQDSLEIHEIGNSGPSNSFSVIQEQSTGSSNAKFERVCRKSLLVG 330

  Fly   335 DIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRI 399
            ||:||..:...||||::||:.....:|::||.|||||||||.:.||.:|...............:
pombe   331 DIVKVLADEAIPADLLILSTENSNGVCYVETKNLDGETNLKDKYALCSTKCCKSEYRCSAASFWV 395

  Fly   400 ECELPNRHLYEFNGVLRETG---------------KPPAALGNDQVLQRGAILRNTAWVFGIVVY 449
            |||.|:..||..|||::..|               :.|.::.|  ||..|..|||:.||.|:|:|
pombe   396 ECEQPHADLYSLNGVVKAPGAVQSPSESTNGRKIHEEPFSISN--VLLCGCTLRNSKWVIGLVLY 458

  Fly   450 SGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISG-LCNLFWTREHSETDWYLGLT 513
            :|.||::.||....|.|||.:.:..|..|::.|::|.::|:.|| |.:::..:.:|...:.|...
pombe   459 TGSETRIQKNRGLTPSKRSRITRDLNWTIILNFLLLFAMCLFSGVLRSIYSAQNNSARVFELSKN 523

  Fly   514 DFKTKSLG-YNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLN 577
            .....:.| .::.|..||:.||:||||.:|:::||.:|:.||..|.|||.|:.:.|...::.|::
pombe   524 SNTAPAHGIISIFTSLILFQNLVPISLYITMDIVRSIQSYFIFSDREMYDEKLDCPCSPKSWNIS 588

  Fly   578 EELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY------------------------------- 611
            ::||.::|||||||||||||:|.||||||.|..|
pombe   589 DDLGQIEYIFSDKTGTLTQNIMSFKKCSINGIRYGKSHNEDTCIKKRRNLNYNENLSCKVDLDKK 653

  Fly   612 --------TAERTPEESQLVQNILGRH--------ETSAVIEEFLELLSVCHTVIPERKENGNMI 660
                    :....||....:.:....|        :|.|.. ||.:.|::||:|:.:.::. .:|
pombe   654 KMLETLSLSDSPNPESITFISSKFVDHLQSNENYIQTEACF-EFFKALALCHSVVTDVQDE-TLI 716

  Fly   661 YHAASPDERALVEGAQKFGY-IFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPE 724
            |:|.||||.|||:.|:.||: :.:|:..:|. |...|..|.:.||:::.|||:|||||:|:|..:
pombe   717 YNAQSPDEEALVKVARDFGFTLLNTKNRRYT-IRIRGENKNFRVLDIIPFTSTRKRMSVIIRDED 780

  Fly   725 NKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDK 789
            ..|.|.||||||||:.||:.......|:|.:||..|:|:|.||||:|...|....|.||...|::
pombe   781 GIIHLICKGADTVIFPRLSSGQNNIIEKTKKHLASFSSEGFRTLCIARRTIDKQDYLEWKVNFNE 845

  Fly   790 ASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAI 854
            |:.|:..|..|:...:.:||..|.|||.|||||:||:.||||||.|..|||.:|||||||.||||
pombe   846 ANSAIHERNEKVSKVSEMIEQELELLGGTAIEDKLQENVPETIALLAIAGIKLWVLTGDKVETAI 910

  Fly   855 NIGYSCRLISHSMDIIILNEESLDATREV-------IHRHYG------EF----KSSSAKDANVA 902
            ||||||.|:..:|.|..::..|..|..||       :..::|      ||    |..|......|
pombe   911 NIGYSCNLLDPNMTIFRIDANSFGALEEVEAFIRNTLCFNFGYMGTDEEFRFLLKDHSPPSPKHA 975

  Fly   903 LVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDV 967
            :||||..|.:.||..:...|..||..|:.|:||||||.|||.||.:|.:|.|.||||||||||||
pombe   976 IVIDGDALNFVLSEQVSFLFLMLCKQCKTVLCCRVSPSQKAAVVALVKKSLNVVTLAIGDGANDV 1040

  Fly   968 AMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYV 1032
            :|||:|:||:||.||||..|:.::||:|.||.:|.|||||||.|:|.|:|::|.:.|||||....
pombe  1041 SMIQEADVGVGIKGVEGQAASMSADYAIGQFSFLGRLLLVHGRWDYKRMSQMISFFFYKNVIWTF 1105

  Fly  1033 IELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLF 1097
            |..|:..|:.:.|..:|:...:.|:|:|||::|....|.|::...|...::.|.||:.......:
pombe  1106 ILFWYQFYNEFDGNYIFDYTYVMLFNLLFTSLPVIIAGCFDQDVDASVSMKNPSLYQRGILGLEW 1170

  Fly  1098 NVKVFWIWIFNALLHSVFLFWLPLAAYT--KEVIWSDGKTSD-------------------YLLM 1141
            |.|.||.::.:.:..|:..|.:.|..:.  ..|.|: |:..:                   ::||
pombe  1171 NGKRFWSYMLDGIYQSLVCFGVALFVFKFGDFVSWT-GRNIECIEDIGLFISSPTIFVINIFILM 1234

  Fly  1142 G----NLVYTYVIVTVCLKAGLITNSWTWLTHLAI-WGSIVLWFGFLLIYSHVWPMFKFASN--- 1198
            .    ||:            .||    ||:..:.: |    :|   ..|||.|.|.:.|..:
pombe  1235 NQERLNLI------------SLI----TWMFSIGVFW----IW---TFIYSEVGPSYAFHKSASR 1276

  Fly  1199 ---------FRGMDIQLLSTPVF-YFCL--MLVPITTLLIDVI-CKLVHNTVFKTLTEAVRETEI 1250
                     ...:.|.|...|.| |.||  :..|..   ||:: .:|...:..:|.:.:...|:|
pombe  1277 TCQTFGFWCVTVLTIALCLLPRFSYICLQKLFYPRD---IDLLRRRLCAKSDDETSSSSSFATDI 1338

  Fly  1251 RRSDISEVMNEPRSSDSGFG 1270
               ::.|..|:|.||....|
pombe  1339 ---EMCEQCNDPLSSKKNSG 1355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	23/67 (34%)
		ATPase-Plipid	229..1247	CDD:273734	411/1238 (33%)
		E1-E2_ATPase	286..>371	CDD:278548	35/181 (19%)
		Cation_ATPase	645..741	CDD:289987	43/96 (45%)
		HAD_like	<942..1001	CDD:304363	37/58 (64%)
		PhoLip_ATPase_C	988..1240	CDD:292829	77/293 (26%)
SPAC4F10.16c	NP_594759.1	ATPase-Plipid	128..1318	CDD:273734	409/1221 (33%)
		PhoLip_ATPase_N	<128..174	CDD:292826	19/45 (42%)
		Cation_ATPase	702..800	CDD:289987	45/99 (45%)
		R3H	854..913	CDD:294210	36/58 (62%)
		HAD_like	<1013..1050	CDD:304363	25/36 (69%)
		PhoLip_ATPase_C	1061..1310	CDD:292829	73/272 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710