Protein Alignment ATP8A and dnf2

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_592849.1
• Gene: dnf2 / 2541560
• PomBaseID: SPAC24B11.12C
• Length: 1402
• Species: Schizosaccharomyces pombe
• Alignment Length: 1367
• Identity: 437/1367 - (31%)
• Similarity: 679/1367 - (49%)
• Gaps: 307/1367 - (22%)

  Fly   166 LSRQSGKSRVSLLAQRGLRMTASFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKYG 230
            |....|....||   |||:      :..||.|         .|....|.|   ::..|.....:.
pombe    43 LEEYDGSDPQSL---RGLQ------KLPRTLY---------FGLPLPDSE---LDDTGEAKRWFP 86

  Fly   231 NNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQI----PEVSPTGRYTTLVPLMFILSV 291
            .|:|.||||:.|.|:|..:|.||:..:|.|||.:.|||.|    .:|:|.   ...|||:.::.:
pombe    87 RNKIRTAKYTPIDFIPKNIFLQFQNVANLFFLFLVILQSISIFGEQVNPG---LAAVPLIVVVGI 148

  Fly   292 SAIKEIIEDIKRHRADNEINH-------------------------------------------- 312
            :|:|:.|||.:|...|..:|:
pombe   149 TAVKDAIEDFRRTMLDIHLNNTPTLRLSHYQNPNIRTEYISYFRRFKKRISALFRVFLAKQEEKK 213

  Fly   313 ----------------------------------RSIE--------------------------- 316
                                              ||.|
pombe   214 RAKRLNDAVPLEDMAGSESRPSYDSIFRESFEAKRSFEDSKGKVPLSALDGTATILQSRPMDIID 278

  Fly   317 -RLDSGSWCTVR---WSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIR 377
             ..::...|..:   |.::.|||.:||..|...|||:::::||:|:.:|:|||.|||||||||:|
pombe   279 YEAEATGECHFKKTYWKDVRVGDFVKVMDNDEIPADIVIINSSDPEGICYIETKNLDGETNLKMR 343

  Fly   378 QALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLR-------------ETGKPPAALGNDQ 429
            .||.....:::....:|....||.|.|:.:|||:||..:             :|...|.:|  |.
pombe   344 HALTCGKNVVDEASCERCRFWIESEPPHANLYEYNGACKSFVHSEAGGSDTSQTVSEPISL--DS 406

  Fly   430 VLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGL 494
            :|.||.:||||.||.|:||::|.:||:|.||.:.|||||.:.:..|..:.:.|:||.|:|.:..:
pombe   407 MLLRGCVLRNTKWVIGVVVFTGDDTKIMLNSGAPPLKRSRITRNLNWNVYLNFIILFSMCFVCAV 471

  Fly   495 CNLFWTREHSETDWYLGLTDFKTKSLGYN-----LLTFF---ILYNNLIPISLQVTLELVRFLQA 551
            ......|.||.:.:|     |:..|:|.:     ::|||   ||:.||:||||.:::|:|:.:||
pombe   472 VEGIAWRGHSRSSYY-----FEFGSIGGSPAKDGVVTFFTGVILFQNLVPISLYISIEIVKTIQA 531

  Fly   552 IFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY----- 611
            |||.:|.:||:::.......::.|::::||.|:||||||||||||||||||||:|.|..|
pombe   532 IFIYFDKDMYYKKLKYACTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVAYGEAFT 596

  Fly   612 -------------TAERTPEE---------------------------------SQLVQNILGR- 629
                         |.|.|.::                                 ||.|.::.|:
pombe   597 EAMAGMAKREGKDTEELTLQKQSFIERDRMQMISQMRNMHDNKYLVDDNLTFISSQFVHDLAGKA 661

  Fly   630 -HETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEIN 693
             .|.|....||...|::||:|:.:| ....::|.|.||||.|||..|:..|::|..:....:...
pombe   662 GEEQSLACYEFFLALALCHSVVADR-VGDRIVYKAQSPDEAALVGTARDVGFVFLDQRRDIMVTR 725

  Fly   694 ALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQA-FREQTLRHL 757
            |||..:|:::::.:||:|:|||||:||:.|:|:..|.|||||::|:|||.|..|. .|:.|..||
pombe   726 ALGETQRFKLMDTIEFSSARKRMSVIVKGPDNRYVLICKGADSIIFERLEPNEQVELRKTTSEHL 790

  Fly   758 EEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIED 822
            ..||.:||||||:|..::..:.|.||.:.:|.|:.|::|||.::|:.|:|||::|.|||.|||||
pombe   791 RIFALEGLRTLCIAKRELTEEEYYEWKEKYDIAASAIENREEQIEEVADLIESHLTLLGGTAIED 855

  Fly   823 RLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATREV---- 883
            |||:|||::||.|..|||.:|||||||.|||||||:||.|:...||:|..:.:...:|.|:
pombe   856 RLQEGVPDSIALLAQAGIKLWVLTGDKMETAINIGFSCNLLDAGMDMIKFDVDQEVSTPELEVIL 920

  Fly   884 ---IHRHYG-----EFKSSSAKDANV-----ALVIDGTTLKYALSCDLRNDFQDLCILCRVVICC 935
               ::|::|     |...::.||.:.     ||||||:.||..|...:|..|..||..|:.|:||
pombe   921 ADYLYRYFGLSGSVEELEAAKKDHDTPSGSHALVIDGSVLKRVLDGPMRTKFLLLCKRCKAVLCC 985

  Fly   936 RVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRY 1000
            ||||.|||:||::|.:|...:|||||||||||||||||::|:||.|.||..||.::||:|.|||:
pombe   986 RVSPAQKADVVQLVRESLEVMTLAIGDGANDVAMIQKADIGVGIVGEEGRAAAMSADYAIGQFRF 1050

  Fly  1001 LQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMP 1065
            |.:|:||||.|:|.|:::::...|||:|.......|:.:|:.:....||:...:.|:|::|:::|
pombe  1051 LSKLVLVHGRWDYNRVAEMVNNFFYKSVVWTFTLFWYQIYNNFDANYLFDYTYVMLFNLIFSSLP 1115

  Fly  1066 PFAMGLFEKFCTAETMIRYPMLYKTS----QNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTK 1126
            ...||::::...|:..:|.|.|||..    .:|:    |:|..::.:....||..|:..... ..
pombe  1116 VIVMGVYDQDVNADLSLRIPQLYKRGILQLNSAR----KIFIGYMLDGFYQSVICFFFSFLV-IN 1175

  Fly  1127 EVIWSDGKTSDYLLMGNL-VYTYVIVTVCLKAGLITNSWTW-LTHLAIWGSIVLWFGFLL-IYS- 1187
            .|..:.....|.:.:.:| ||......:.:...:|.|...| :..:.:|....|.|.|.. :||
pombe  1176 NVTTAAQNGRDTMAVQDLGVYVAAPTIMVVDTYVILNQSNWDVFSIGLWALSCLTFWFWTGVYSQ 1240

  Fly  1188 --HVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEI 1250
              :.:..:|.||       ::..||.|:             .|:|..:.:.:|....
pombe  1241 SLYTYEFYKSAS-------RIFRTPNFW-------------AVLCGTIVSCLFPKFL-------- 1277

  Fly  1251 RRSDISEVMNEPRSSDSGFGYALGKLIRSSHILISHDHHPVSESSRTSNLRVENLEMEADTEQQQ 1315
                                     .:.:..:...:|...:.||.||.  |:..|:.|.:.|..:
pombe  1278 -------------------------FMTTQKLFWPYDVDIIRESYRTK--RLHELDEEEEIENAE 1315

  Fly  1316 QS 1317
            ||
pombe  1316 QS 1317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	389/1097 (35%)
dnf2	NP_592849.1	Haloacid Dehalogenase-like Hydrolases	85..1295	CDD:473868	413/1278 (32%)