DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and SPBC887.12

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_596486.1	Gene:	SPBC887.12 / 2541239	PomBaseID:	SPBC887.12	Length:	1258	Species:	Schizosaccharomyces pombe

Alignment Length:	1291	Identity:	556/1291 - (43%)
Similarity:	781/1291 - (60%)	Gaps:	119/1291 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LGSSASQRRRQQRIAQ-QRQDSWFRHSMPPAINRDFESLEHLTPRASDGLDEQLAASVSHSVHSG 94
            :......::..:||:: :.:|.:...||   :.|..::     |...:...|.:..|.|..:.|.
pombe     1 MARDVDNKQNAKRISRDEDEDEFAGESM---VGRTLDN-----PFLGEDEFEDIFGSESQYISSS 57

  Fly    95 G---------SVTLCGPP---DHSSIHLNSANSNLGFIDSDTP----NTPVTPVSGLQPPASVST 143
            |         ...:...|   :..:..||...:|:..|  :.|    |.|..|.|.|.||.:
pombe    58 GQNSTNPFLADTRIENSPLGSESKANQLNKQGTNVNHI--EIPLRDFNDPTQPESFLPPPKN--- 117

  Fly   144 SVGGTLSSRRRSSNRKDSKGSILSRQSGKSRVSLLAQRGLRMTASFLRRKRTEYEDDEDFTSSAG 208
                |.:||                              ::...:..::::.:.:.:
pombe   118 ----TFTSR------------------------------IKKIKNLFKKEKKQVKPE-------- 140

  Fly   209 YDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEV 273
               |.|.|:|| ||......:.:|.::|.|||..:|||.||.|||.:|:|.|||..|::||||.:
pombe   141 ---DLGPRQII-LNDYSANHFLHNAVSTCKYSAFTFLPKFLKEQFSKYANLFFLFTAVVQQIPGI 201

  Fly   274 SPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIK 338
            :|..||||:.|::.:||||.||||:|||||.:.|.|:|......|....:...:|.::.||||:|
pombe   202 TPVNRYTTIGPMLIVLSVSGIKEIMEDIKRKKQDQELNESPCYVLQGTGFVEKQWKDVVVGDIVK 266

  Fly   339 VGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECEL 403
            :...|||||||:|||||||:.:|:||||||||||||||:||||.||.||:..:|.:|.|.::.|.
pombe   267 IVSETFFPADLVLLSSSEPEGLCYIETANLDGETNLKIKQALPETAGLLKPVELGQLSGEVKSEQ 331

  Fly   404 PNRHLYEFNGVL------RETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTS 462
            ||.:||.|:..|      ||....|     ||:|.|||.||||.||:||||::|.|:|||||:|.
pombe   332 PNNNLYTFDATLKLLPSDRELPLSP-----DQLLLRGAQLRNTPWVYGIVVFTGHESKLMKNTTE 391

  Fly   463 APLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGYNLLTF 527
            .|:||::|:|..|:|||.|..|.:.||..|.|..|.....:.....|:..|..:.......||||
pombe   392 TPIKRTSVEKQVNSQILFLLCIFVFLCFASSLGALIHRSVYGSALSYVKYTSNRAGMFFKGLLTF 456

  Fly   528 FILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTG 592
            :|||:||:||||.||.||||::||..|:.|::||:||::|||..|||:|.||||.|.||||||||
pombe   457 WILYSNLVPISLFVTFELVRYIQAQLISSDLDMYNEETDTPAACRTSSLVEELGQVGYIFSDKTG 521

  Fly   593 TLTQNVMEFKKCSIAGYVYTAERTPEESQ-----------------LVQNILGRH-ETSAVIEEF 639
            |||:|.|||::|:|||..| |:..||:.|                 |.:|:  :| |.:::|.:|
pombe   522 TLTRNQMEFRQCTIAGVAY-ADVIPEDRQFTSEDLDSDMYIYDFDTLKENL--KHSENASLIHQF 583

  Fly   640 LELLSVCHTVIPERKENGNMI-YHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEV 703
            |.:||:|||||||..|:.|.| |.|:||||.|||:||...||.|..|.|..|.::..|..:.||:
pombe   584 LLVLSICHTVIPEYDESTNSIKYQASSPDEGALVKGAASIGYKFLARKPHLVTVSIFGKDESYEL 648

  Fly   704 LNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTL 768
            |::.||.|:|||||::.|.|:.||:|:.|||||||.|||| ....:.:.|:.|||::|:.|||||
pombe   649 LHICEFNSTRKRMSIVFRCPDGKIRLYVKGADTVIMERLA-SDNPYLQTTIHHLEDYATVGLRTL 712

  Fly   769 CLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIA 833
            |:|:.::..|.||.||..|:.|:.:|.:|..||.|||..||.:|.||||||||||||||||:||:
pombe   713 CIAMREVPEDEYQRWSTVFETAASSLVDRAQKLMDAAEEIEKDLILLGATAIEDRLQDGVPDTIS 777

  Fly   834 SLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHRHYGEFKSSSAKD 898
            :|..|||.|||||||:||||||||.||:||...|.::|:|||:.:||.|.:.........:.|..
pombe   778 TLQTAGIKIWVLTGDRQETAINIGMSCKLIDEDMGLVIVNEETKEATAESVMAKLSSIYRNEATT 842

  Fly   899 ANV---ALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAI 960
            .||   ||||||.:|.|||...|...|.:|..|||.||||||||:|||.:|:||.::|..|.|||
pombe   843 GNVESMALVIDGVSLTYALDFSLERRFFELASLCRAVICCRVSPLQKALIVKMVKRNTGEVLLAI 907

  Fly   961 GDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFY 1025
            |||||||.|||.|:||:||||:|||||..:||:||:||.||::||||||:|.|.|:|||||||||
pombe   908 GDGANDVPMIQAAHVGVGISGMEGLQAVRSSDFSISQFCYLKKLLLVHGSWCYQRLSKLILYSFY 972

  Fly  1026 KNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKT 1090
            ||:.||:.:.|:|..:.:|||::||.|:|.|||||||.:||..:|:|::|.:|..:.:||.||:.
pombe   973 KNIALYMTQFWYAFCNAFSGQVIFESWSISLYNVLFTVLPPVVIGIFDQFVSAGQLFQYPQLYQL 1037

  Fly  1091 SQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCL 1155
            .|.::.||:|.||.||.|...||:.||...:|.:..:....||..|.:.:.|..:|..::.||..
pombe  1038 GQRSEFFNLKRFWSWITNGFYHSLLLFLCSIAVFYYDGPNKDGLASGHWVWGTTLYAAILATVLG 1102

  Fly  1156 KAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVP 1220
            ||.||:|.||..|.:|..||.:||..|:.||:...|...|:..:.|:...|.....|:..|:::|
pombe  1103 KAALISNHWTQYTVIATLGSFLLWIVFMPIYAVAAPAIGFSKEYYGIIPHLYGNLKFWASLLVLP 1167

  Fly  1221 ITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRSSDSGFGYALGKL 1276
            ...|:.|.:.|......:......|:  ||::.::::.  .||.  .||..|:.|:
pombe  1168 TIALMRDFVWKYSSRMYYPEEYHYVQ--EIQKYNVTDY--RPRI--VGFHKAIRKI 1217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	29/61 (48%)
		ATPase-Plipid	229..1247	CDD:273734	513/1045 (49%)
		E1-E2_ATPase	286..>371	CDD:278548	45/84 (54%)
		Cation_ATPase	645..741	CDD:289987	51/96 (53%)
		HAD_like	<942..1001	CDD:304363	38/58 (66%)
		PhoLip_ATPase_C	988..1240	CDD:292829	103/251 (41%)
SPBC887.12	NP_596486.1	PhoLip_ATPase_N	147..208	CDD:292826	29/61 (48%)
		ATPase-Plipid	157..1194	CDD:273734	513/1047 (49%)
		E1-E2_ATPase	213..>307	CDD:278548	52/93 (56%)
		Cation_ATPase	590..686	CDD:289987	51/95 (54%)
		HAD_like	<736..935	CDD:304363	118/198 (60%)
		PhoLip_ATPase_C	935..1186	CDD:292829	103/250 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	338	1.000	Domainoid score	I194
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	976	1.000	Inparanoid score	I41
OMA	1	1.010	-	-		QHG53737
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		oto100723
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1985
SonicParanoid	1	1.000	-	-		X168
TreeFam	1	0.960	-	-
	13	12.860