DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and Atp8b4

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_001074413.2	Gene:	Atp8b4 / 241633	MGIID:	1859664	Length:	1194	Species:	Mus musculus

Alignment Length:	1188	Identity:	467/1188 - (39%)
Similarity:	699/1188 - (58%)	Gaps:	125/1188 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 RIINLNG---PQPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGR 278
            |::..|.   .:..:|.:|||.|:||:.::|||..||||.:|.:|.:||.:.|||.|||:|....
Mouse    14 RVVKANDRDYNEKFQYADNRIHTSKYNVLTFLPINLFEQLQRVANAYFLFLLILQLIPEISSLTW 78

  Fly   279 YTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINT 343
            :||:|||:.::|::|:|:..:|..||::||::|:|..:.|.:......:|..:.||||||:..|.
Mouse    79 FTTIVPLVLVISMTAVKDATDDYFRHKSDNQVNNRQSKVLINSKLQNEKWMNVKVGDIIKLENNQ 143

  Fly   344 FFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAEL-LETKDLQRLEGRIECELPNRH 407
            |..|||:|||||||..:|::|||.||||||||:|||||.|:|| .:...|...:|.:.||.||..
Mouse   144 FVAADLLLLSSSEPHGLCYVETAELDGETNLKVRQALPVTSELGADISSLAEFDGIVRCEAPNNK 208

  Fly   408 LYEFNGVLR-ETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVD 471
            |..|:|||. :..|  .||.|.:::.||.:||||:|.||:|:::|.:||||:||.....||:::|
Mouse   209 LDRFSGVLSWKDSK--HALSNQKIILRGCVLRNTSWCFGMVLFAGPDTKLMQNSGKTKFKRTSID 271

  Fly   472 KLTNTQILMLFMILISLCIISGLCNL--------------FWTREHSETDWYLGLTDFKTKSLGY 522
            :|.||.:|.:|..|:.|.||..:.:.              || ||..::..:.|...|
Mouse   272 RLMNTLVLWIFGFLVCLGIILAVGSSILESEVGDQFRTPPFW-REGEKSFLFSGFLTF------- 328

  Fly   523 NLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIF 587
              .::.|:.|.|:||||.|::|::|...:.|||:|.:||:.....||.|||:.||||||.::|||
Mouse   329 --WSYVIILNTLVPISLYVSVEVIRLGHSYFINWDRKMYYASKAMPAEARTTTLNEELGQIEYIF 391

  Fly   588 SDKTGTLTQNVMEFKKCSIAGYVYTAERTPE-----------------------------ESQLV 623
            ||||||||||:|.||||||.|.||..|...:                             :..|:
Mouse   392 SDKTGTLTQNIMTFKKCSINGRVYAGEVLDDPIQKKEITKEKEATDFSSKSKSEKTLHFFDQSLM 456

  Fly   624 QNI-LGRHETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTP 687
            ::| ||    ...:.|||.||::||||:.|....|.::|...||||.|||..|:.||:||.:|||
Mouse   457 ESIELG----DPKVHEFLRLLALCHTVMSEENSAGQLVYQVQSPDEGALVTAARNFGFIFKSRTP 517

  Fly   688 KYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQ 752
            :.:.|..||....|::|..|:|.:.|||||:|||.||.:|||:.|||||:::|:|.|..:..:..
Mouse   518 ETITIEELGTPVTYQLLAFLDFNNIRKRMSVIVRNPEGRIKLYSKGADTILFEKLHPSNEDLQSL 582

  Fly   753 TLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGA 817
            |..||.|||.:|||||.:|..::....::.|.:..:.|:.|...|:.::......||.:|.||||
Mouse   583 TSDHLSEFAGEGLRTLAIAYRELDDKYFKMWQKMLEDANSATLERDERISGLYEEIERDLMLLGA 647

  Fly   818 TAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMD-IIILNEESLDATR 881
            ||:||:||:||.|||.||..|.|.||:||||||||||||||:|.:::.:|| :.::...:....|
Mouse   648 TAVEDKLQEGVIETITSLSLANIKIWILTGDKQETAINIGYACNVLTDAMDALFVITGNTAGEVR 712

  Fly   882 EVIHRHYGEFKSSSAKDAN------------------------VALVIDGTTLKYALSCDLRNDF 922
            |.:.:........|...:|                        .||||:|.:|.:||..|:.||.
Mouse   713 EELRKAKENLLGQSTSFSNGHAVYDNKQRLGLDAGAGEAVTGEYALVINGHSLAHALESDVENDL 777

  Fly   923 QDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQA 987
            .:|..:|:.|:||||:|:|||:|||:|.:..||||||||||||||:||:.|::||||||.|||||
Mouse   778 LELACVCKTVVCCRVTPLQKAQVVELVKKHRNAVTLAIGDGANDVSMIKSAHIGIGISGQEGLQA 842

  Fly   988 ACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERW 1052
            ..||||::||||||||||||||.|:|.|:.|.:.|.||||....::..|||.:.|:|.|.::::|
Mouse   843 VLASDYALAQFRYLQRLLLVHGRWSYYRMCKFLCYFFYKNFAFTLVHFWFAFFCGFSAQTVYDQW 907

  Fly  1053 TIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLF 1117
            .|.|:|:::|::|..|||:|::....:..:.||.||:..|...|||.:.|:|.:.:.:..|:.||
Mouse   908 FITLFNIVYTSLPVLAMGMFDQDINEQNSMDYPQLYEPGQLNLLFNKRRFFICVAHGIYTSLALF 972

  Fly  1118 WLPLAAYTKEVIWSDGK-TSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFG 1181
            ::|..|: ..|...||: .:|.......|.|.:::.|.::..|.|:.||.:.|:.||||:..:|.
Mouse   973 FIPYGAF-YNVAAEDGQHIADLQSFAVTVATSLVIVVSIQIALDTSYWTVVNHVFIWGSVATYFS 1036

  Fly  1182 FLL-IYSH----VWPM-FKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKT 1240
            .|| ::|.    ::|. |.|..|.|    ..||....:..::|..:|:::..|:.:.:...::.:
Mouse  1037 ILLAMHSDGVFGIFPRHFPFVGNAR----HSLSQKFVWLVVLLTAVTSVMPVVVVRFLKMYLYPS 1097

  Fly  1241 LTEAVRETEIRRSDISEVMNEP---------RSSDSGFGYAL------GKLIRSSHILISHDHHP 1290
            |::     :|||...::....|         |||....|||.      |:||.|...:.:....|
Mouse  1098 LSD-----QIRRWQKAQRKKRPLRSRRPQTRRSSSRRSGYAFAHQEGYGELITSGKNMRAKSPAP 1157

  Fly  1291 VS--ESSRTSNLR-VENL 1305
            .|  |....:|.. :|||
Mouse  1158 ASGLEKKLYNNTSWIENL 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	26/64 (41%)
		ATPase-Plipid	229..1247	CDD:273734	444/1095 (41%)
		E1-E2_ATPase	286..>371	CDD:278548	36/84 (43%)
		Cation_ATPase	645..741	CDD:289987	47/95 (49%)
		HAD_like	<942..1001	CDD:304363	42/58 (72%)
		PhoLip_ATPase_C	988..1240	CDD:292829	88/258 (34%)
Atp8b4	NP_001074413.2	P-type_ATPase_APLT_Dnf-like	31..975	CDD:319770	410/959 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.730