DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and ATP11A

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	XP_005268356.1	Gene:	ATP11A / 23250	HGNCID:	13552	Length:	1192	Species:	Homo sapiens

Alignment Length:	1109	Identity:	413/1109 - (37%)
Similarity:	623/1109 - (56%)	Gaps:	92/1109 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 PTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILS 290
            |.:|.:|||.::||:|.:|:|..|||||||.:|.:||:|.::|.|.: :||...|:.:||.|:::
Human    42 PQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLIIFLVQLIID-TPTSPVTSGLPLFFVIT 105

  Fly   291 VSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSS 355
            |:|||:..||..||:|||.:|...:..:..|.....:..:|.||||:.|..:..||.|||.|||:
Human   106 VTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSN 170

  Fly   356 EPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNG---VLRE 417
            .....|.:.||:||||::.|...|:..|......:|:..|...||||.|...||:|.|   |..:
Human   171 RGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSD 235

  Fly   418 TGKPPA-ALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILML 481
            ...|.. .||::.:|.|||.|:||..:||:.:|:|.|||:..|..|...|||.|:|..|..:::.
Human   236 LNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVY 300

  Fly   482 FMILISLCIISGLCNLFWTRE-HSETDWY--------------LGLTDFKTKSLGYNLLTFFILY 531
            ..||||..:|:.:....|..| ..:..||              ...|||         |.|.:|:
Human   301 LCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF---------LAFMVLF 356

  Fly   532 NNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQ 596
            |.:||:|:.||:|:.:||.:.||.:|.:|:.||:....:..||:||||||.|:|||:|||||||:
Human   357 NYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTE 421

  Fly   597 NVMEFKKCSIAGYVY------TAERTPEESQL-----VQNILGRHETSAVIEEFLELLSVCHTVI 650
            |.||||:|.|.|:||      ..:..||.|.:     ..::.||...    |.|...|.:||||.
Human   422 NNMEFKECCIEGHVYVPHVICNGQVLPESSGIDMIDSSPSVNGRERE----ELFFRALCLCHTVQ 482

  Fly   651 ---------PERKENG--NMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEI-NALGVRKRYEV 703
                     |.:..:|  :.:|.::||||.|||||.|:.|:.:......|:|| |.....:|:|:
Human   483 VKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLKDNYMEILNRENHIERFEL 547

  Fly   704 LNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTL 768
            |.:|.|.|.|:|||:||::...:|.|||||||:.|:.|:. :|:.  :|....:|..|.:|||||
Human   548 LEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVI-EGKV--DQIRARVERNAVEGLRTL 609

  Fly   769 CLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIA 833
            |:|...:..:.|:...:....|.||||:||.||.:|...||.:|.||||||:|||||:...:||.
Human   610 CVAYKRLIQEEYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIE 674

  Fly   834 SLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIIL-----NEESL-DATREV---IHRHYG 889
            :|..|||.:|||||||.|||....|:|:|...:..::.|     .|:|| |...|:   :.||.|
Human   675 ALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQLLELTTKRIEEQSLHDVLFELSKTVLRHSG 739

  Fly   890 -----EFKSSSAKDANVALVIDGTTLKYAL-------SCDLRNDFQDLCILCRVVICCRVSPMQK 942
                 .....||...:..|:|||..|...:       |.:.|..|.::|..|..|:|||::|:||
Human   740 SLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRMAPLQK 804

  Fly   943 AEVVEMVTQS-TNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLL 1006
            |::|:::..| .:.:|||||||||||:||.:|:||||:.|.||.|||..|||:|.:|::|:::||
Human   805 AQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLL 869

  Fly  1007 VHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGL 1071
            |||.:.|.|||:|:.|.||||||....:..:..:.|:|.|.|::...:.|||:.||::|.....|
Human   870 VHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSL 934

  Fly  1072 FEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTS 1136
            .|:....:.:.|.|.||:......|...:||..|....|..::..|:.....:....:.|:|:..
Human   935 MEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVFFFGAYFVFENTTVTSNGQIF 999

  Fly  1137 DYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHV-WPMFKFASNFR 1200
            .....|.||:|.::.||.||..|.|:.|||:.|..||||::.:..|.|::..| ||...:...:.
Human  1000 GNWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYVVFSLLWGGVIWPFLNYQRMYY 1064

  Fly  1201 GMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRSS 1265
             :.||:||:...:..::|:...:||.||:.|::...::.|.||.|::....         :||..
Human  1065 -VFIQMLSSGPAWLAIVLLVTISLLPDVLKKVLCRQLWPTATERVQQNGCA---------QPRDR 1119

  Fly  1266 DSGF 1269
            ||.|
Human  1120 DSEF 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	25/53 (47%)
		ATPase-Plipid	229..1247	CDD:273734	407/1082 (38%)
		E1-E2_ATPase	286..>371	CDD:278548	33/84 (39%)
		Cation_ATPase	645..741	CDD:289987	43/107 (40%)
		HAD_like	<942..1001	CDD:304363	33/59 (56%)
		PhoLip_ATPase_C	988..1240	CDD:292829	81/252 (32%)
ATP11A	XP_005268356.1	PhoLip_ATPase_N	42..95	CDD:292826	25/53 (47%)
		ATPase-Plipid	45..1110	CDD:273734	407/1082 (38%)
		E1-E2_ATPase	102..>187	CDD:278548	34/84 (40%)
		Cation_ATPase	477..585	CDD:289987	43/107 (40%)
		R3H	639..695	CDD:294210	33/55 (60%)
		HAD_like	<806..849	CDD:304363	23/42 (55%)
		PhoLip_ATPase_C	851..1103	CDD:292829	81/252 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720