Protein Alignment ATP8A and ATP11A

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_001392590.1
• Gene: ATP11A / 23250
• HGNCID: 13552
• Length: 1192
• Species: Homo sapiens
• Alignment Length: 1109
• Identity: 413/1109 - (37%)
• Similarity: 623/1109 - (56%)
• Gaps: 92/1109 - (8%)

  Fly   226 PTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILS 290
            |.:|.:|||.::||:|.:|:|..|||||||.:|.:||:|.::|.|.: :||...|:.:||.|:::
Human    42 PQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLIIFLVQLIID-TPTSPVTSGLPLFFVIT 105

  Fly   291 VSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSS 355
            |:|||:..||..||:|||.:|...:..:..|.....:..:|.||||:.|..:..||.|||.|||:
Human   106 VTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSN 170

  Fly   356 EPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNG---VLRE 417
            .....|.:.||:||||::.|...|:..|......:|:..|...||||.|...||:|.|   |..:
Human   171 RGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSD 235

  Fly   418 TGKPPA-ALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILML 481
            ...|.. .||::.:|.|||.|:||..:||:.:|:|.|||:..|..|...|||.|:|..|..:::.
Human   236 LNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVY 300

  Fly   482 FMILISLCIISGLCNLFWTRE-HSETDWY--------------LGLTDFKTKSLGYNLLTFFILY 531
            ..||||..:|:.:....|..| ..:..||              ...|||         |.|.:|:
Human   301 LCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDF---------LAFMVLF 356

  Fly   532 NNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQ 596
            |.:||:|:.||:|:.:||.:.||.:|.:|:.||:....:..||:||||||.|:|||:|||||||:
Human   357 NYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTE 421

  Fly   597 NVMEFKKCSIAGYVY------TAERTPEESQL-----VQNILGRHETSAVIEEFLELLSVCHTVI 650
            |.||||:|.|.|:||      ..:..||.|.:     ..::.||...    |.|...|.:||||.
Human   422 NNMEFKECCIEGHVYVPHVICNGQVLPESSGIDMIDSSPSVNGRERE----ELFFRALCLCHTVQ 482

  Fly   651 ---------PERKENG--NMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEI-NALGVRKRYEV 703
                     |.:..:|  :.:|.::||||.|||||.|:.|:.:......|:|| |.....:|:|:
Human   483 VKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLKDNYMEILNRENHIERFEL 547

  Fly   704 LNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTL 768
            |.:|.|.|.|:|||:||::...:|.|||||||:.|:.|:. :|:.  :|....:|..|.:|||||
Human   548 LEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVI-EGKV--DQIRARVERNAVEGLRTL 609

  Fly   769 CLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIA 833
            |:|...:..:.|:...:....|.||||:||.||.:|...||.:|.||||||:|||||:...:||.
Human   610 CVAYKRLIQEEYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIE 674

  Fly   834 SLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIIL-----NEESL-DATREV---IHRHYG 889
            :|..|||.:|||||||.|||....|:|:|...:..::.|     .|:|| |...|:   :.||.|
Human   675 ALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQLLELTTKRIEEQSLHDVLFELSKTVLRHSG 739

  Fly   890 -----EFKSSSAKDANVALVIDGTTLKYAL-------SCDLRNDFQDLCILCRVVICCRVSPMQK 942
                 .....||...:..|:|||..|...:       |.:.|..|.::|..|..|:|||::|:||
Human   740 SLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRMAPLQK 804

  Fly   943 AEVVEMVTQS-TNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLL 1006
            |::|:::..| .:.:|||||||||||:||.:|:||||:.|.||.|||..|||:|.:|::|:::||
Human   805 AQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLL 869

  Fly  1007 VHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGL 1071
            |||.:.|.|||:|:.|.||||||....:..:..:.|:|.|.|::...:.|||:.||::|.....|
Human   870 VHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSL 934

  Fly  1072 FEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTS 1136
            .|:....:.:.|.|.||:......|...:||..|....|..::..|:.....:....:.|:|:..
Human   935 MEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVFFFGAYFVFENTTVTSNGQIF 999

  Fly  1137 DYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHV-WPMFKFASNFR 1200
            .....|.||:|.::.||.||..|.|:.|||:.|..||||::.:..|.|::..| ||...:...:.
Human  1000 GNWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYVVFSLLWGGVIWPFLNYQRMYY 1064

  Fly  1201 GMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRSS 1265
             :.||:||:...:..::|:...:||.||:.|::...::.|.||.|::....         :||..
Human  1065 -VFIQMLSSGPAWLAIVLLVTISLLPDVLKKVLCRQLWPTATERVQQNGCA---------QPRDR 1119

  Fly  1266 DSGF 1269
            ||.|
Human  1120 DSEF 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	367/952 (39%)
ATP11A	NP_001392590.1	P-type_ATPase_APLT_Dnf-like	47..983	CDD:319770	367/952 (39%)
		RDD	<965..1061	CDD:469900	29/95 (31%)