Protein Alignment ATP8A and ATP11B

DIOPT Version :9

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_055431.1
• Gene: ATP11B / 23200
• HGNCID: 13553
• Length: 1177
• Species: Homo sapiens
• Alignment Length: 1098
• Identity: 424/1098 - (38%)
• Similarity: 623/1098 - (56%)
• Gaps: 98/1098 - (8%)

  Fly   226 PTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILS 290
            |.|:.:|||.::||:..:|:|..|||||||.:|.:||:|.::|.:.: :||...|:.:||.|:::
Human    36 PQKFIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLMID-TPTSPVTSGLPLFFVIT 99

  Fly   291 VSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSS 355
            |:|||:..||..||.:|||:|...:..:.||.....|...:.||||:::..:..|||||:||||.
Human   100 VTAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSD 164

  Fly   356 EPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNG------V 414
            .....|.:.||:||||||||...|:|.||.|....:|..|...|||:.|...||.|.|      .
Human   165 RLDGSCHVTTASLDGETNLKTHVAVPETALLQTVANLDTLVAVIECQQPEADLYRFMGRMIITQQ 229

  Fly   415 LRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQIL 479
            :.|..:|   ||.:.:|.|||.|:||..:||:.||:|.|||:..|..|...|||.|:|..||.::
Human   230 MEEIVRP---LGPESLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLI 291

  Fly   480 MLFMILISLCIISGLCNLFWTREHS-ETDWYLGLTDFK---TKSLGY--NLLTFFILYNNLIPIS 538
            :..:||||..:||.:....|..|.. :..||...|:.:   :|.|.:  :.|.|.:|||.:||||
Human   292 IYLVILISEAVISTILKYTWQAEEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFIIPIS 356

  Fly   539 LQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKK 603
            |.||:|:.:||.:.||.:|:::|||||:..|...||:||||||.|:|:|:|||||||:|.|:|::
Human   357 LYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRE 421

  Fly   604 CSIAGYVYTAER--------TPEESQLVQNILG---------------------RHETSAVIEE- 638
            |||.|..|....        ||:.|:...:.|.                     .:||..:.|.
Human   422 CSINGMKYQEINGRLVPEGPTPDSSEGNLSYLSSLSHLNNLSHLTTSSSFRTSPENETELIKEHD 486

  Fly   639 -FLELLSVCHTV-------------------IPERKENGNMIYHAASPDERALVEGAQKFGYIFD 683
             |.:.:|:||||                   .|.:.|     |:|:||||:||||.|.:.|.:|.
Human   487 LFFKAVSLCHTVQISNVQTDCTGDGPWQSNLAPSQLE-----YYASSPDEKALVEAAARIGIVFI 546

  Fly   684 TRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQA 748
            ..:.:.:|:..||..:||::|::|||.|.|:|||:||:.|..:..||.|||::.|..:.. .|:.
Human   547 GNSEETMEVKTLGKLERYKLLHILEFDSDRRRMSVIVQAPSGEKLLFAKGAESSILPKCI-GGEI 610

  Fly   749 FREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLR 813
              |:|..|::|||..||||||:|........|:|..:...:|..|||.||.||......||.:|.
Human   611 --EKTRIHVDEFALKGLRTLCIAYRKFTSKEYEEIDKRIFEARTALQQREEKLAAVFQFIEKDLI 673

  Fly   814 LLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLD 878
            ||||||:||||||.|.|||.:|..|||.:|||||||.|||:::..||.....:|:|:.|..:..|
Human   674 LLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNILELINQKSD 738

  Fly   879 A---------TREVIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVIC 934
            :         .|.:...|..:.          .||:|||:|..||. :....|.::|..|..|:|
Human   739 SECAEQLRQLARRITEDHVIQH----------GLVVDGTSLSLALR-EHEKLFMEVCRNCSAVLC 792

  Fly   935 CRVSPMQKAEVVEMVTQS-TNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQF 998
            ||::|:|||:|:.::..| ...:|||:|||||||:|||:|:|||||.|.||.|||..|||:||:|
Human   793 CRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAIARF 857

  Fly   999 RYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTA 1063
            ::|.:||.|||.:.|.||:.|:.|.||||||....:..:..|..:|.|.|::...:.|||:.||:
Human   858 KFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTS 922

  Fly  1064 MPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHS-VFLFWLPLAAYTKE 1127
            :|.....|.|:......:...|.||:.....:|.::|.|..|......|: :|.|...|......
Human   923 LPILIYSLLEQHVDPHVLQNKPTLYRDISKNRLLSIKTFLYWTILGFSHAFIFFFGSYLLIGKDT 987

  Fly  1128 VIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHV-WP 1191
            .:..:|:.......|.||:|.:::||.:|..|.|:.|||:.||..||||:.:|.|.|.|..: ||
Human   988 SLLGNGQMFGNWTFGTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFVFSLFYGGILWP 1052

  Fly  1192 MFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETE 1249
             |..:.|...:.|||||:...:|.::|:.:|.|.:|:|.|:....:..|.||..:.||
Human  1053 -FLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDIIKKVFDRHLHPTSTEKAQLTE 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	23/53 (43%)
		ATPase-Plipid	229..1247	CDD:273734	420/1091 (38%)
		E1-E2_ATPase	286..>371	CDD:278548	34/84 (40%)
		Cation_ATPase	645..741	CDD:289987	42/114 (37%)
		HAD_like	<942..1001	CDD:304363	35/59 (59%)
		PhoLip_ATPase_C	988..1240	CDD:292829	86/253 (34%)
ATP11B	NP_055431.1	PhoLip_ATPase_N	35..89	CDD:292826	23/53 (43%)
		ATPase-Plipid	39..1106	CDD:273734	420/1090 (39%)
		E1-E2_ATPase	96..>180	CDD:278548	34/83 (41%)
		Cation_ATPase	494..605	CDD:289987	42/115 (37%)
		HAD_like	629..868	CDD:304363	109/249 (44%)
		PhoLip_ATPase_C	847..1100	CDD:292829	86/253 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720