DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and ATP10B

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_001353581.1	Gene:	ATP10B / 23120	HGNCID:	13543	Length:	1461	Species:	Homo sapiens

Alignment Length:	1420	Identity:	416/1420 - (29%)
Similarity:	642/1420 - (45%)	Gaps:	321/1420 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 ILSRQSGKSRVSLLAQRGLRMTASFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKY 229
            :||.:.|:...:|..||.:....|...:                 |.::..||           |
Human    30 LLSPEKGRQSYNLTQQRVVFPNNSIFHQ-----------------DWEEVSRR-----------Y 66

  Fly   230 GNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAI 294
            ..||..|.||:..:|||..|||||.|::|.:||.:.||..:|.:....|..|::||..:|.|..|
Human    67 PGNRTCTTKYTLFTFLPRNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIVLFVIMI 131

  Fly   295 KEIIEDIKRHRADNEINHRSI---ERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSE 356
            |:.:||.||||.|..||..:|   ||.:. ::....|.::.|||.|::..|...|||::||.||:
Human   132 KDGMEDFKRHRFDKAINCSNIRIYERKEQ-TYVQKCWKDVRVGDFIQMKCNEIVPADILLLFSSD 195

  Fly   357 PQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRETGKP 421
            |..:|.:|||:||||||||.|..:...::.....:.:.....|.||.||.||.:|.|.:....:.
Human   196 PNGICHLETASLDGETNLKQRCVVKGFSQQEVQFEPELFHNTIVCEKPNNHLNKFKGYMEHPDQT 260

  Fly   422 PAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILI 486
            ....|.:.:|.||..:|||....|||:|:|.|||.|.|::....|||.:::..|..|.....|||
Human   261 RTGFGCESLLLRGCTIRNTEMAVGIVIYAGHETKAMLNNSGPRYKRSKIERRMNIDIFFCIGILI 325

  Fly   487 SLCIISGLCNLFWT---REHSETDWYLGLTDFKTKSLG--YNLLTFFILYNNLIPISLQVTLELV 546
            .:|:|..:.:..|.   .||...|.......|...:||  |..||..||...||||||.|::|||
Human   326 LMCLIGAVGHSIWNGTFEEHPPFDVPDANGSFLPSALGGFYMFLTMIILLQVLIPISLYVSIELV 390

  Fly   547 RFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY 611
            :..|..|::.|:::|.||::.....|..|:.|:||.::|||||||||||:|.|.|::|:|.|..|
Human   391 KLGQVFFLSNDLDLYDEETDLSIQCRALNIAEDLGQIQYIFSDKTGTLTENKMVFRRCTIMGSEY 455

  Fly   612 T-----------------------------------------------------AERTPEESQLV 623
            :                                                     :.|.|.:....
Human   456 SHQENAKRLETPKELDSDGEEWTQYQCLSFSARWAQDPATMRSQKGAQPLRRSQSARVPIQGHYR 520

  Fly   624 QNILGRHE-----------------------------------------------TSAVIEEFLE 641
            |..:|..|                                               |::.|.:|..
Human   521 QRSMGHRESSQPPVAFSSSIEKDVTPDKNLLTKVRDAALWLETLSDSRPAKASLSTTSSIADFFL 585

  Fly   642 LLSVCHTVI--------------PERKENGNMI-------------------------------- 660
            .|::|::|:              |..|..|..:
Human   586 ALTICNSVMVSTTTEPRQRVTIKPSSKALGTSLEKIQQLFQKLKLLSLSQSFSSTAPSDTDLGES 650

  Fly   661 ----------------------------------------------------------------- 660

Human   651 LGANVATTDSDERDDASVCSGGDSTDDGGYRSSMWDQGDILESGSGTSLEEALEAPATDLARPEF 715

  Fly   661 -YHAASPDERALVEGAQKFGYIFDTRTPKYVEIN-ALGVRKRYEVLNVLEFTSSRKRMSLIVRTP 723
             |.|.||||.|||..|..:.:...:|||:.|.:. ..|....:.:|..|.|.|.|||||::||.|
Human   716 CYEAESPDEAALVHAAHAYSFTLVSRTPEQVTVRLPQGTCLTFSLLCTLGFDSVRKRMSVVVRHP 780

  Fly   724 -ENKIKLFCKGADTVIYERLAPQG-----------QAFREQTLRHLEEFASDGLRTLCLAVADIR 776
             ..:|.::.||||:||.:.|....           :..|.:|.:||:.:|.|||||||:|...:.
Human   781 LTGEIVVYTKGADSVIMDLLEDPACVPDINMEKKLRKIRARTQKHLDLYARDGLRTLCIAKKVVS 845

  Fly   777 PDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIY 841
            .:.::.|:....:|..:|.||:..|.:.|..:||.|.|||||.||||||:|||:|||:|.:|||.
Human   846 EEDFRRWASFRREAEASLDNRDELLMETAQHLENQLTLLGATGIEDRLQEGVPDTIATLREAGIQ 910

  Fly   842 IWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHRHYGEFK-------------- 892
            :|||||||||||:||.:||||::.:..:..:|.|:.:....:::....|.|
Human   911 LWVLTGDKQETAVNIAHSCRLLNQTDTVYTINTENQETCESILNCALEELKQFRELQKPDRKLFG 975

  Fly   893 ----------SSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVE 947
                      :|.|......|||||.||.......|...|.:|...||.|:|||.:|:||:.:|:
Human   976 FRLPSKTPSITSEAVVPEAGLVIDGKTLNAIFQGKLEKKFLELTQYCRSVLCCRSTPLQKSMIVK 1040

  Fly   948 MVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWN 1012
            :|......:||:||||||||:|||.|::||||||.||:||..:||::|.:|::|::||||||.|.
Human  1041 LVRDKLRVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAITRFKHLKKLLLVHGHWC 1105

  Fly  1013 YARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCT 1077
            |:|::::::|..|||||...:..|:..:.|:|...:.:.|.:..:|:.||::||...|:.:|..:
Human  1106 YSRLARMVVYYLYKNVCYVNLLFWYQFFCGFSSSTMIDYWQMIFFNLFFTSLPPLVFGVLDKDIS 1170

  Fly  1078 AETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMG 1142
            |||::..|.|||:.||::.:|:..|||.:.:|...|:..|::|..||       .|...|....|
Human  1171 AETLLALPELYKSGQNSECYNLSTFWISMVDAFYQSLICFFIPYLAY-------KGSDIDVFTFG 1228

  Fly  1143 NLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASN-FRGMDIQL 1206
            ..:.|..:.|:.|...:...:||....:.:.||.:::|...|:|:....:....:| :..|:.|
Human  1229 TPINTISLTTILLHQAMEMKTWTIFHGVVLLGSFLMYFLVSLLYNATCVICNSPTNPYWVMEGQ- 1292

  Fly  1207 LSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRE-----TEIRRSDISEVMNEPRSSD 1266
            ||.|.||....|.|:..||.......:..|..|:|....::     .:.|..:|....:..|.:
Human  1293 LSNPTFYLVCFLTPVVALLPRYFFLSLQGTCGKSLISKAQKIDKLPPDKRNLEIQSWRSRQRPA- 1356

  Fly  1267 SGFGYALGKLIRSSHILISHDHHPVSESSRTSNLRVENLEMEADTEQQQQSRQRQ 1321
                 .:.::.|.:       |||||.        :...:..|.|.:.....:|:
Human  1357 -----PVPEVARPT-------HHPVSS--------ITGQDFSASTPKSSNPPKRK 1391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	22/61 (36%)
		ATPase-Plipid	229..1247	CDD:273734	394/1275 (31%)
		E1-E2_ATPase	286..>371	CDD:278548	36/87 (41%)
		Cation_ATPase	645..741	CDD:289987	39/209 (19%)
		HAD_like	<942..1001	CDD:304363	31/58 (53%)
		PhoLip_ATPase_C	988..1240	CDD:292829	76/252 (30%)
ATP10B	NP_001353581.1	P-type_ATPase_APLT_Dnf-like	68..1213	CDD:319770	362/1145 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..541		5/44 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..687		0/47 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1346..1397		11/67 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830