Protein Alignment ATP8A and tat-2

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_001294447.1
• Gene: tat-2 / 177256
• WormBaseID: WBGene00019166
• Length: 1349
• Species: Caenorhabditis elegans
• Alignment Length: 1287
• Identity: 478/1287 - (37%)
• Similarity: 699/1287 - (54%)
• Gaps: 194/1287 - (15%)

  Fly   228 KYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVS 292
            ||.:|.|.|:||:.|:|:|..|||||:|.:|.:||::.|||.||::|....|:|.|||:.:|:.|
 Worm    70 KYADNVIKTSKYNIITFIPQNLFEQFQRIANFYFLVLMILQFIPQISSISWYSTAVPLVIVLAFS 134

  Fly   293 AIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEP 357
            |||:..:|.:||.:|..:|.|....:.:||.|...||.:.|||:|::..|.|..|||:|||:|||
 Worm   135 AIKDGYDDAQRHISDRNVNGRKSYVVRNGSLCEEDWSNVKVGDVIRMMSNQFVAADLLLLSTSEP 199

  Fly   358 QAMCFIETANLDGETNLKIRQALPATAELLETKD-LQRLEGRIECELPNRHLYEFNGVL----RE 417
            ..:|||||..||||||||.|.|:..|.|:.:..| :.|.:|.|.||.||..|.:|||.|    .|
 Worm   200 YGVCFIETMELDGETNLKNRAAIACTQEMGDDLDGITRFDGEIICEPPNNKLDKFNGKLIWNNHE 264

  Fly   418 TGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLF 482
            .|     :.||.:|.||.||:||.|.:|:||::|::||||.||.....||:::|:..|..|:.:.
 Worm   265 YG-----VNNDNILLRGCILKNTRWCYGVVVFAGKDTKLMMNSGKTKFKRTSLDRFLNILIVGIV 324

  Fly   483 MILISLCIISGLCNLFWTREHSE-----TDW-------------YLGLTDFKTKSLGYNLLTFFI 529
            :.||::|:|..:....|..:...     ..|             .:.|..|      ....::.|
 Worm   325 LFLIAMCLICTILCAVWEYQTGRYFTIYLPWDDVVPSPEQRGGRQIALIAF------LQFFSYII 383

  Fly   530 LYNNLIPISLQVTLELVRFLQAIFINYDIEMYHE--ESNTPAMARTSNLNEELGMVKYIFSDKTG 592
            |.|.::||||.|::|::||:.:::||||.:||:|  |.:.||.|.|:.||||||.|:|:||||||
 Worm   384 LLNTVVPISLYVSVEIIRFIHSLWINYDTQMYYENGEKSVPAKAHTTTLNEELGQVQYVFSDKTG 448

  Fly   593 TLTQNVMEFKKCSIAGYVY------------TAERT------------PEESQLVQNILGRHETS 633
            |||:|:|.|.||:|.|..|            |.::|            |......:|::...:..
 Worm   449 TLTRNIMTFNKCTINGISYGDIYDHKGEVIETNDKTKSLDFSWNSASEPTFKFFDKNLVDATKRQ 513

  Fly   634 A-VIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGV 697
            . .|::|..||::||||:||| :.|.::|.|.||||.||...|:.|||:|..|||:.:.|..:|.
 Worm   514 VPEIDQFWRLLALCHTVMPER-DKGQLVYQAQSPDEHALTSAARNFGYVFRARTPQSITIEVMGN 577

  Fly   698 RKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQ-GQAFREQTLRHLEEFA 761
            .:.:|:|.:|:|.:.|||||:||:.|:.||:|:|||||.:|.:|:.|. .|..|..|..||.:||
 Worm   578 EETHELLAILDFNNDRKRMSVIVKGPDGKIRLYCKGADMMIMQRIHPSTSQIMRTSTNTHLADFA 642

  Fly   762 SDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQD 826
            :.|||||||...|:.|..:.:|.....|||.|:|:|||.::.....||.:|.|:|||||||:|||
 Worm   643 NIGLRTLCLGYKDLDPAYFSDWDSRVKKASAAMQDRESAVDALYEEIEKDLILIGATAIEDKLQD 707

  Fly   827 GVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLIS-HSMDIIILN-------EESLDATR-- 881
            ||||.||.|.:|.|.||||||||.||||||.|||||:: .:.:|::::       |..|..||
 Worm   708 GVPEAIARLSEANIKIWVLTGDKTETAINIAYSCRLLTDETKEIVVVDGQTDTEVEVQLKDTRNT 772

  Fly   882 -------------------EVIHRHYGEFKSSSAKDAN------------------VALVIDGTT 909
                               |.||.......|:.:.|.|                  |||||:|.:
 Worm   773 FEQILALPSPLGGKPRIEIETIHEESEAISSARSMDRNIVTPDLKSAEMAEHESGGVALVINGDS 837

  Fly   910 LKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKAN 974
            |.:||...|...|.::..:|..||||||:|:|||:||::|.::..||||:||||||||:||:.|:
 Worm   838 LAFALGPRLERTFLEVACMCNAVICCRVTPLQKAQVVDLVKRNKKAVTLSIGDGANDVSMIKTAH 902

  Fly   975 VGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAV 1039
            :|:||||.||:||..||||||.||:||:|||||||.|:|.|::|.:.|.||||....:...|::.
 Worm   903 IGVGISGQEGMQAVLASDYSIGQFKYLERLLLVHGRWSYIRMAKFLRYFFYKNFAFTLTNFWYSF 967

  Fly  1040 YSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWI 1104
            :.|:|.|.:|:...|..||:.|||:|..|||..::.......:|||.||...|....||:::|..
 Worm   968 FCGYSAQTVFDAVLIACYNLFFTALPVLAMGSLDQDVDDHYSLRYPKLYLPGQFNLFFNMRIFIY 1032

  Fly  1105 WIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTH 1169
            .:.:.:..|:.:|::|..|:......|.....||..:....:|.::|.|..:....|:.||.::|
 Worm  1033 SVLHGMFSSLVIFFIPYGAFYNAAAASGKDLDDYSALAFTTFTALVVVVTGQIAFDTSYWTAISH 1097

  Fly  1170 LAIWGSIVLWF-GFLLIYSHV---WPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVIC 1230
            ..||||:||:| ...|:|..:   |.:...:|...|:..:.:.||.|:|.:::|.:..||..::.
 Worm  1098 FVIWGSLVLYFLVCFLLYEWLPVSWIVKTSSSISYGVAFRTMVTPHFWFSILMVSVVLLLPVMLN 1162

  Fly  1231 KL----VH-----------------------NTVFKTLTEAVRETEIRRSDISEVMNEPRSS--- 1265
            :.    .|                       .|.||      |....|||    |....||.
 Worm  1163 RFFWLDTHPSFADRLRIRKKMGKKPSAKDDKKTAFK------RTAATRRS----VRGSLRSGYAF 1217

  Fly  1266 --DSGFGYAL--GKLIRSSHILISHDH-----HPVS-------------ESSRTSNLRVENLEM- 1307
              ..|||..:  |||.::...|...::     ||.|             :|...|::...:|.|
 Worm  1218 SHSQGFGELILKGKLFKNVENLRGKNNSNAKIHPTSDDLQPMLISSVPDDSQGASSINAMHLPMG 1282

  Fly  1308 ----------EADTEQQQQSRQ-RQKWR------GGQVATGVARSARNSTTS 1342
                      ..:|:...||.. |..:.      .|.|..|..||.||...|
 Worm  1283 TRPQNVPHTLNVNTDDWSQSSDFRPAYAKEPSPLQGTVIRGDGRSHRNHVYS 1334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	408/986 (41%)
tat-2	NP_001294447.1	P-type_ATPase_APLT_Dnf-like	73..1048	CDD:319770	408/986 (41%)