DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and tat-1

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_001255165.1	Gene:	tat-1 / 176666	WormBaseID:	WBGene00013034	Length:	1192	Species:	Caenorhabditis elegans

Alignment Length:	1050	Identity:	521/1050 - (49%)
Similarity:	716/1050 - (68%)	Gaps:	23/1050 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 KYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVS 292
            ::.:|||:|.||:..||||.||:||||||:|.|||.||:|||||:|||||||||.||.:.|||||
Worm    27 RFCSNRISTCKYNGFSFLPRFLYEQFRRYNNIFFLAIALLQQIPDVSPTGRYTTAVPFLIILSVS 91

  Fly   293 AIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEP 357
            |:|||.||:||.|:||::|..|:|.|..|.|...:|.:::|||.|::..::.|||||:||:|||.
Worm    92 ALKEIFEDVKRRRSDNKVNAFSVEILVDGHWIEKQWKDVSVGDFIRIDNDSLFPADLLLLASSEQ 156

  Fly   358 QAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRETGKPP 422
            |.|.:|||:||||||||||:|||..|:.:...:.|.:.|..|.||.|:||:.||||.:...| ..
Worm   157 QGMAYIETSNLDGETNLKIKQALDITSTMTSPEKLSQFESEITCEPPSRHVNEFNGNIEING-VA 220

  Fly   423 AALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILIS 487
            ...|.||:|.|||.|:||||:||.|:|:|.::||:.||..||||..|:|..||.:|:.||.:|::
Worm   221 RHFGIDQLLLRGARLKNTAWIFGAVIYTGHDSKLLMNSKRAPLKSGTIDVQTNYRIIFLFFVLVA 285

  Fly   488 LCIISGLCNLFWTREHSETDWYLGLTDFKTK-SLGYNLLTFFILYNNLIPISLQVTLELVRFLQA 551
            |.:||...:..|...:....|||...:...| |..:.:||||||||||||||||||||:|||.||
Worm   286 LALISATGSEIWRGNNIPQAWYLSFLEHDPKGSFLWGVLTFFILYNNLIPISLQVTLEVVRFFQA 350

  Fly   552 IFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERT 616
            |:||.|||||...|::.|:|||||||||||.||:|.||||||||:|||:||:.||....|.....
Worm   351 IYINNDIEMYDVNSDSCAIARTSNLNEELGQVKFIMSDKTGTLTRNVMKFKRLSIGSRNYGNNED 415

  Fly   617 PE--ESQLVQNILGRHETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFG 679
            .|  ::.|:::.....|.|..|.|.|::::|||||:||.|: |.:||.::||||.|||.||....
Worm   416 DEFADASLIEDYRQGDEHSTSILEVLKMMAVCHTVVPENKD-GQLIYQSSSPDEAALVRGAASQS 479

  Fly   680 YIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRT-PENKIKLFCKGADTVIYERL- 742
            ..|.||.|:.|..|..|..:..|:|:|::|||.|||||:|||. ....|||:.|||||||:|||
Worm   480 VSFHTRQPQKVICNVFGEDETIEILDVIDFTSDRKRMSVIVRDGAGGDIKLYTKGADTVIFERLE 544

  Fly   743 --APQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAA 805
              ..|.:|. |....|||::||.|.||||.::..:....|.:|:..:.||.:|:.||...|.|||
Worm   545 HGKEQEEAV-EYCTEHLEDYASFGYRTLCFSMRHLTEQEYSQWAPEYKKAILAIDNRAKLLADAA 608

  Fly   806 NLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDII 870
            ..:|.|:.|:|||||||:||:.|||||.:|:.|.|.:|:|||||:||||||.:||.|...:.:::
Worm   609 EKLERNMILVGATAIEDKLQEWVPETIQALMAADIRVWMLTGDKRETAINIAHSCALCHTNTELL 673

  Fly   871 ILNEESLDATREVIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICC 935
            |:::.:.:.|.:.:.:..........::...|:||||.:|.:||:.:.|..|.||.:.|..|:||
Worm   674 IVDKTTYEETYQKLEQFVARAIELEKQEKGFAMVIDGKSLLHALTGEARKHFGDLALRCHAVVCC 738

  Fly   936 RVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRY 1000
            |:||||||||||||.:....|.||||||||||||||.||||:||||.||||||.||||:|.:|.:
Worm   739 RMSPMQKAEVVEMVRKLAKHVVLAIGDGANDVAMIQAANVGVGISGEEGLQAASASDYAIPRFHF 803

  Fly  1001 LQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMP 1065
            |:||||||||||:.|..|:||||||||:|||:||||||::|.||||.:|||||||::||:|||.|
Worm   804 LRRLLLVHGAWNHDRSVKVILYSFYKNICLYIIELWFAMFSAWSGQTIFERWTIGMFNVIFTAWP 868

  Fly  1066 PFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIW 1130
            |..:|||:....||.:::||.||.:.|| :.|::..|.:||..|::||:.||:|..|....:|:|
Worm   869 PVVLGLFDHPVPAEQIMKYPALYASFQN-RAFSIGNFSLWIGLAIVHSLSLFFLTYATMEHQVVW 932

  Fly  1131 SDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWP-MFK 1194
            .:|.|..:|::||..||:|:.|||.||.|..:||||...:|..|||.||..|:::||.|:| :..
Worm   933 DNGLTGGWLMLGNCAYTFVVATVCFKALLECDSWTWPVVVACIGSIGLWIVFVIVYSLVFPHIGG 997

  Fly  1195 FASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVM 1259
            ..::..||...::|:..|:..|:.:|:.|||.|::.|.:......|..|           ::.:.
Worm   998 IGADMAGMAAIMMSSYTFWLALLFIPLATLLWDLVIKSLFTIAMPTPRE-----------LAVMY 1051

  Fly  1260 NEPRSSDSGF 1269
            |:..:|.:||
Worm  1052 NKRTTSFNGF 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	35/51 (69%)
		ATPase-Plipid	229..1247	CDD:273734	517/1025 (50%)
		E1-E2_ATPase	286..>371	CDD:278548	45/84 (54%)
		Cation_ATPase	645..741	CDD:289987	51/96 (53%)
		HAD_like	<942..1001	CDD:304363	43/58 (74%)
		PhoLip_ATPase_C	988..1240	CDD:292829	120/252 (48%)
tat-1	NP_001255165.1	PhoLip_ATPase_N	16..79	CDD:292826	35/51 (69%)
		ATPase-Plipid	28..1036	CDD:273734	515/1011 (51%)
		E1-E2_ATPase	85..>178	CDD:278548	52/92 (57%)
		Cation_ATPase	446..545	CDD:289987	54/99 (55%)
		HAD_like	<745..789	CDD:304363	33/43 (77%)
		PhoLip_ATPase_C	791..1043	CDD:292829	120/252 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167924
Domainoid	1	1.000	351	1.000	Domainoid score	I535
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48402
Inparanoid	1	1.050	993	1.000	Inparanoid score	I146
Isobase	1	0.950	-	0	Normalized mean entropy	S688
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		oto18271
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1985
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890