Protein Alignment ATP8A and tat-4

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_001379745.1
• Gene: tat-4 / 174031
• WormBaseID: WBGene00020784
• Length: 1212
• Species: Caenorhabditis elegans
• Alignment Length: 1265
• Identity: 376/1265 - (29%)
• Similarity: 584/1265 - (46%)
• Gaps: 276/1265 - (21%)

  Fly   153 RRSSNRKDSKGSILSRQSGKSRVSLLAQRGLRMTASFLRR-------KRTEYEDDEDFTSSAGYD 210
            ||||::.....:.|     .:.:|:...|..|.|.|.:.|       .|.|..:..|||
 Worm    11 RRSSSKWVPPSAPL-----HNPISIFRGRSNRETGSRVIRPNHLFESPRYELNNYRDFT------ 64

  Fly   211 ADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQF-RRYSNCFFLLIAILQQIPEVS 274
                                :|||:|.||:|.:|:|..::.|. .:|:|.:|:.||||..:|...
 Worm    65 --------------------DNRISTTKYTFWNFIPLNIWHQVSTKYANLYFIFIAILNWVPFFD 109

  Fly   275 PTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVR---WSELTVGDI 336
            ...||..|:|:.|:|..:.||:.|||.:|::.||:||.::....|... |..|   |..:.|||.
 Worm   110 AYTRYVGLIPICFVLGTTLIKDGIEDYRRYKFDNQINKKTCHVWDRDR-CAFRKTEWRYILVGDF 173

  Fly   337 IKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDL----QRLEG 397
            :.:..|...|||:|||.||.....|:|||.||||||:||.|. :||.......||.    ....|
 Worm   174 VHISNNQDVPADIILLRSSSESGTCYIETCNLDGETSLKQRM-VPAKVIDYSKKDSTFKPPDFTG 237

  Fly   398 RIECELPNRHLYEFNGVLR-ETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNST 461
            .:.||.|::.:|.....:. |.|:....: .:.:|.||:.::||.:|.|||||:|.:||:|:|:.
 Worm   238 VVTCEKPDKSIYTIRAKVEFEPGQSDVII-KENMLLRGSRIKNTTFVEGIVVYAGHDTKVMQNNG 301

  Fly   462 SAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREH---SETDWYLGLT--DFKTKSLG 521
            .||.|.|.::||||..|:..|::|:.:.:...:.:..|..:|   .:..:.|..|  .|....:|
 Worm   302 RAPHKTSGIEKLTNKFIIACFIMLLLMVLYGAITSAVWVGQHPVDEQIPFILSNTPRPFIEGFIG 366

  Fly   522 YNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYI 586
            ..  .|||.|..|:||||.:|:|:::.||..||:.||::|.::|:.....|:.::.||||.|.::
 Worm   367 IG--AFFINYQLLVPISLYITVEIIKALQIYFISNDIQLYDQKSDRAIDCRSLSIPEELGTVTHV 429

  Fly   587 FSDKTGTLTQNVMEFKKCSI--AGY---------------------VYTAERTPEESQLVQNI-- 626
            .||||||||:|:|.|:.|:.  ..|                     :.|:.:.|.:.....||
 Worm   430 LSDKTGTLTENMMIFRNCAFDETDYGSNGSQSNPDKPVKSDELYQRILTSMQNPVQKHFFANILL 494

  Fly   627 --------------------------------------------------------------LGR 629
                                                                          ||.
 Worm   495 NNSVVVNHIPHTDVLELGNFDGGVYNIGNSCFYDVTEEKYKQKLAAIGKGGVDDDDVSRPDELGL 559

  Fly   630 HETS--------AVIEE-----------------------------------FLELLSV------ 645
            ..||        .::||                                   |...||.
 Worm   560 PTTSIQFDDRLTVIVEEDTPSDSPAPDASPRDLPETPTPTSPIYRPLSSLSSFSRKLSTVVRRSI 624

  Fly   646 ---CHTVIPER------KENGNMIYHAASPDERALVEGAQKFGYIFDTR--------TPKYVEIN 693
               ...:||.|      |:.....|.|.||||.||:|||..:.|:...|        ||:..|
 Worm   625 LRPISDIIPVRKRLISFKQQAMNPYEAESPDELALIEGAALYDYVLLERAATSVTISTPEKAE-- 687

  Fly   694 ALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQG-QAFREQTLR-H 756
                 ||||:|..|.|.::|||||:||.:.:..: ::|||||:.|..||:... ::.|.|.|: |
 Worm   688 -----KRYEILLTLPFDATRKRMSVIVNSQKGPL-MYCKGADSAIISRLSSDSLESKRVQDLKDH 746

  Fly   757 LEEFASDGLRTLCLAVADIRPDVYQEWSQTF-----DKASVALQNRESKLEDAANLIENNLRLLG 816
            |:.:|..||||||.|:..|..:.::::..::     |    |...||..|.:.|:.:|.||:|.|
 Worm   747 LDNYAKKGLRTLCFAMKYISKEDFEDFLDSYRFLMED----ATSEREKMLSEKADELETNLKLSG 807

  Fly   817 ATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATR 881
            .|.||||||||||:|:.:|.||||.:|||||||.|||.||..|..|......:.::..|: ||
 Worm   808 VTGIEDRLQDGVPDTLRALRDAGIQVWVLTGDKLETAQNIATSSGLFHPQRSLKVIETET-DA-- 869

  Fly   882 EVIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVV 946
                       ..:::.|.:.:::....::  |:.|......:.....:.|:|.|::|.:||.:|
 Worm   870 -----------EEASESAGLNIIMSPAAIR--LAQDGNAHLMEALKKAKTVLCYRMTPSEKATIV 921

  Fly   947 EMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAW 1011
            ..|.:......||||||||||.|||.|:|||||:|.||||||.|.|::||:|::|.|||||||.|
 Worm   922 NTVKKRIKGNVLAIGDGANDVPMIQAAHVGIGIAGKEGLQAAMACDFAIARFKFLSRLLLVHGHW 986

  Fly  1012 NYARISKLILYSFYKNVCLYVIELWFAVYSGWSG-QILFERWTIGLYNVLFTAMPPFAMGLFEKF 1075
            :|.|::...||..|||.....|..::..|:|.|| .|:...|.: :|.::||::.|..:|:.::.
 Worm   987 SYYRLANTFLYFLYKNANAVFIIFYYQFYNGASGTNIVDPIWGV-IYPIIFTSVQPVVVGVLDQD 1050

  Fly  1076 CTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLL 1140
            ...:|::..|.||...:..:|:..|.|:..:.:.:..:..::::   ||    :..|..||....
 Worm  1051 YDDQTLMNKPELYVIGRENQLYTWKHFFRDVIDGIYQAAVIYYV---AY----LTLDNSTSSLWE 1108

  Fly  1141 MGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRG---- 1201
            ||..:.|..|:.......|....|.|        .:|..|.|.::::..   |.||.....
 Worm  1109 MGFYIATSSILVNSGHLALQVRYWHW--------QLVALFSFFILFNFA---FFFAECLTAAAAM 1162

  Fly  1202 -------MDIQLLSTPVFYFCLMLVPITTL 1224
                   |.|..:..|.|::...:..|..|
 Worm  1163 VPDPPVWMPIHAMGDPRFWYYQFITVIVAL 1192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	336/1063 (32%)
tat-4	NP_001379745.1	P-type_ATPase_APLT_Dnf-like	65..1095	CDD:319770	336/1066 (32%)