Protein Alignment ATP8A and tat-5

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_001021457.1
• Gene: tat-5 / 172748
• WormBaseID: WBGene00009498
• Length: 1074
• Species: Caenorhabditis elegans
• Alignment Length: 1141
• Identity: 331/1141 - (29%)
• Similarity: 559/1141 - (48%)
• Gaps: 144/1141 - (12%)

  Fly   133 SGLQPPASVSTSVGGTLSSRRR-----SSNRKDSKGSILSRQSGKSRVSLLAQRG----LRMTAS 188
            |..|.|...|:|...::|..|.     ::..:|...|:.|..:..|..|  |.:|    .|...|
 Worm    13 SSSQKPCVSSSSDDFSVSFVRAEEDDVATTIRDKTASLKSNATHFSAAS--AAKGGMFDFRCCRS 75

  Fly   189 FLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGP----QPTKYGNNRITTAKYSFISFLPAFL 249
            ...|:|..:..    |...||             ||    ....:..|.:...||:..||:|..|
 Worm    76 LFSRRRVLHSR----TVRVGY-------------GPVGHDANVTFTPNTVCNQKYNIFSFVPIVL 123

  Fly   250 FEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRS 314
            |:||:.:.|.:|||:|..|.||.:......|...||.|:|:::.|:|..:|..|:..|.::|...
 Worm   124 FQQFKFFLNLYFLLMACSQFIPAIQIGAPITYWGPLGFVLTITLIREAFDDFVRYLRDRDLNSEK 188

  Fly   315 IERLD-SGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQ 378
            .|:|. .|:...:|.:::.|||:|.:..:...|||::||.:::....|||.|..|||||:.|:|.
 Worm   189 YEKLTRDGTRIEIRSADIEVGDVIIMHKDRRVPADVVLLRTTDKSGACFIRTDQLDGETDWKLRI 253

  Fly   379 ALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAI-LRNTAW 442
            .:|.|..|....|:..|...:..|.|.:.::.|.|.|:.|        :|..:|.|:: :.|..|
 Worm   254 PVPHTQHLPNEADIMELNCEVYAEKPQKDIHAFVGTLKIT--------DDDNVQDGSLNVENVLW 310

  Fly   443 ---------VFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTN--TQILMLFMILISLCIIS--GL 494
                     ..|||||:|:||:.:.|:|....|...:|...|  |::|..|::::|..:::  ||
 Worm   311 ANTVVASGTAVGIVVYTGRETRSVMNTTLPESKVGLLDLEVNNLTKLLFCFVLVLSSVMVAMKGL 375

  Fly   495 CNLFWTREHSETDWYLGLTDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIE 559
            .||          ||            ..|:.|.:|::.:|||||:|.|::.:..      |..:
 Worm   376 DNL----------WY------------RYLMRFILLFSYIIPISLRVNLDMAKLF------YSWQ 412

  Fly   560 MYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERTPEESQLVQ 624
            :..::.....:.|:|.:.||||.:.::.||||||||:|.|.|||..:....::::...|..|.|:
 Worm   413 IGRDKHIPETVIRSSTIPEELGRISFLLSDKTGTLTKNEMHFKKIHLGTVAFSSDAFEEVGQHVR 477

  Fly   625 NI----LGRHETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTR 685
            :.    |.:|..||.::..:|.:::||.|.| ..|||.:.|.||||||.|||:..:..|....:|
 Worm   478 SAYAGRLAKHSFSAKLQNAVEAIALCHNVTP-IFENGEISYQAASPDEVALVKWTETVGVRLASR 541

  Fly   686 TPKYVEI-----NALGVRKRYEVLNVLEFTSSRKRMSLIVR-TPENKIKLFCKGADTVIYERLAP 744
            ....:.:     |...:.|::::|.|..|||..|||.:||: ...:::.|..||||||:
 Worm   542 DLHAMSLSVQLPNGQTLMKQFQILYVFPFTSETKRMGIIVKDETTDEVTLLMKGADTVM------ 600

  Fly   745 QGQA-FREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAAN-L 807
            .|.. :.:.........|.:|||||.:|...:.....:.:.:.:..|.:::.:|...:.:..| :
 Worm   601 SGMVQYNDWLDEECSNMAREGLRTLVVARKPLSQAELEAFDRAYHAAKMSISDRSQNMANVVNRM 665

  Fly   808 IENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIIL 872
            :|.:|:||..|.:||||||.|..::..|.:|||.||:|||||.||||.|..|..|.|.|.:|.:.
 Worm   666 LERDLQLLCLTGVEDRLQDQVTTSLELLRNAGIKIWMLTGDKLETAICIAKSSGLFSRSDNIHVF 730

  Fly   873 N--EESLDATREVIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICC 935
            .  ....||..|:         ::..:..:||||:.|:.|...|.. ...:..:|...|..|:||
 Worm   731 GNVHNRTDAHNEL---------NNLRRKTDVALVMPGSALNVCLQY-YEAEVAELVCACTAVVCC 785

  Fly   936 RVSPMQKAEVVEMVTQSTNAVTL-AIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFR 999
            |.||.|||::|:::.:....:.: |||||.|||:|||.|:.||||...||.||:.|:|:||.||.
 Worm   786 RCSPEQKAQIVQLLRKYRAPLRVAAIGDGGNDVSMIQAAHAGIGIDANEGKQASLAADFSITQFS 850

  Fly  1000 YLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAM 1064
            ::.|||||||.:.|.|...|..:..::.:.:..::..|:....::...|::...:..|:..:|.:
 Worm   851 HVCRLLLVHGRFCYKRSCALSQFVMHRGLIISTMQAIFSCVFYFASVSLYQGVLMVAYSTCYTML 915

  Fly  1065 PPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVI 1129
            |.|:: :.::..||...:.||.|||.....:..:.|.|.||:..:|.....:.:..|..:
 Worm   916 PVFSL-VVDRDVTATNALTYPELYKELGKGRSLSYKTFCIWVLISLYQGAVIMYGALLVF----- 974

  Fly  1130 WSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFK 1194
                 .:|::.:.::.::.:|||..:...:..::|.|...||...|:.|:...|:::...:
 Worm   975 -----DADFIHVVSISFSALIVTELIMVAMTVHTWHWAMLLAQALSLGLYMISLILFDQYF---- 1030

  Fly  1195 FASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVIC 1230
                    |.|.:.:.||      :..||.:..|.|
 Worm  1031 --------DRQFVLSWVF------ISKTTAITAVSC 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	288/918 (31%)
tat-5	NP_001021457.1	P-type_ATPase_APLT_Neo1-like	105..995	CDD:319841	293/953 (31%)
		Cation_ATPase	501..600	CDD:463817	37/99 (37%)