DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and Atp10a

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_033858.2	Gene:	Atp10a / 11982	MGIID:	1330809	Length:	1508	Species:	Mus musculus

Alignment Length:	1452	Identity:	447/1452 - (30%)
Similarity:	675/1452 - (46%)	Gaps:	349/1452 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 PASVSTSVGGTLSSRRRSSNRKDSKGSILSRQSGKSRV---SLLAQRGLRMTASFLRRKRTEYED 199
            ||:..::..|....|||             |..|::|.   :||...|
Mouse     6 PAAEESASSGWRRPRRR-------------RWEGRTRTVRSNLLPPLG----------------- 40

  Fly   200 DEDFTSSAGYDADDGERRII-----NLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNC 259
                |..:...|..|||.::     :|        .:||:.|.||:.:||||..|||||.|.:|.
Mouse    41 ----TEDSTIGAPKGERLLMRGCIQHL--------ADNRLKTTKYTLLSFLPKNLFEQFHRLANV 93

  Fly   260 FFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRS--IERLDSGS 322
            :|:.||:|..:|.|:.......|.|::|||:|:|||::.||..|||:|:||||..  :...:...
Mouse    94 YFVFIALLNFVPAVNAFQPGLALAPVLFILAVTAIKDLWEDYSRHRSDHEINHLGCLVFSREEKK 158

  Fly   323 WCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELL 387
            :....|.|:.|||.:::..|...|||::|||||:|..:|.|||||||||||||.||.:...:||:
Mouse   159 YVNRYWKEIRVGDFVRLCCNEIIPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSELV 223

  Fly   388 ETKDLQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQ 452
            ...:.......||||.||..|..|.|.:..:....|.|..:.:|.||..:|||..|.|||:|:|.
Mouse   224 SEFNPLTFTSVIECEKPNNDLSRFRGYIMHSNGEKAGLHKENLLLRGCTIRNTEAVAGIVIYAGH 288

  Fly   453 ETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKT 517
            |||.:.|::....|||.:::..|..:|...::|:.:.:.|.:.:..|.|.:.|......:.:...
Mouse   289 ETKALLNNSGPRYKRSQLERQMNCDVLWCVLLLVCISLFSAVGHGLWVRRYQEKKALFDVPESDG 353

  Fly   518 KSLG------YNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNL 576
            .||.      |:..|..|:...||||||.|::|:|:..|..|||.|||:|.||:::....|..|:
Mouse   354 SSLSPATAAVYSFFTMIIVLQVLIPISLYVSIEIVKVCQVYFINQDIELYDEETDSQLQCRALNI 418

  Fly   577 NEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYT-----------AERTPEESQLV------- 623
            .|:||.:||||||||||||:|.|.|::|:::|..|:           .|...||.::|
Mouse   419 TEDLGQIKYIFSDKTGTLTENKMVFRRCTVSGIEYSHDANAQRLARYQEADSEEEEVVSKVGTIS 483

  Fly   624 --------QNILGRHETSAV--------------------------------------------- 635
                    |:|...|:|.::
Mouse   484 HRGSTGSHQSIWMTHKTQSIKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPDPKLLEKVSEC 548

  Fly   636 -----------------------IEEFLELLSVCHTVI--------------------------- 650
                                   :.:|...|::|:||:
Mouse   549 DRFLAIARHQEHPLAHLSPELSDVFDFFIALTICNTVVVTSPDQPRQKVRVRFELKSPVKTIEDF 613

  Fly   651 -----PER--------------------------------------------------------- 653
                 |.|
Mouse   614 LRRFTPSRLASGCSSIGNLSTSKSSHKSGSAFLPSLSQDSMLLGLEEKLGQTAPSIASNGYASQA 678

  Fly   654 ----------------------KENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKY--VEINA 694
                                  ::.|.:.|.|.||||.|||..|:.:......|....  ||:..
Mouse   679 GQEESWASECTTDQKCPGEQREQQEGELRYEAESPDEAALVYAARAYNCALVDRLHDQVSVELPH 743

  Fly   695 LGVRKRYEVLNVLEFTSSRKRMSLIVRTP-ENKIKLFCKGADTVIYERLAP---------QGQAF 749
            || |..:|:|:.|.|.|.|||||:::|.| .::|.::.||||:|:.:.|.|         ..:..
Mouse   744 LG-RLTFELLHTLGFDSIRKRMSVVIRHPLTDEINVYTKGADSVVMDLLLPCSSDDARGRHQKKI 807

  Fly   750 REQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRL 814
            |.:|..:|..:|.:||||||:|...:..:.|..|.|:..:|..::::||..|..:|..:|.||.|
Mouse   808 RSKTQNYLNLYAVEGLRTLCIAKRVLSKEEYACWLQSHIEAEASVESREELLFQSAVRLETNLHL 872

  Fly   815 LGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDA 879
            ||||.||||||:|||||||.|..||:.|||||||||||||||.|:|:|:.|..::|.||.:|.:|
Mouse   873 LGATGIEDRLQEGVPETIAKLRQAGLQIWVLTGDKQETAINIAYACKLLDHGEEVITLNADSQEA 937

  Fly   880 TREVIHRHYGEFKS-----------------------SSAKDA--NVALVIDGTTLKYALSCDLR 919
            ...::.:.....:|                       |::.||  :.:|||||.:|.|||...|.
Mouse   938 CAALLDQCLSYVQSRNPRSTLQNSESNLSVGFSFNPVSTSTDASPSPSLVIDGRSLAYALEKSLE 1002

  Fly   920 NDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEG 984
            :.|..|...||.|:|||.:|:||:.||::|.....|:|||||||||||:|||.|:||:||||.||
Mouse  1003 DKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEG 1067

  Fly   985 LQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILF 1049
            :||..|||:::.:||||:|||:|||.|.|:|::.::||.||||.....:..||..|.|:|...:.
Mouse  1068 MQAVMASDFAVPRFRYLERLLIVHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFYCGFSASAMI 1132

  Fly  1050 ERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSV 1114
            ::|.:..:|:||:::|....|:.:|...|:.::|.|.|||:.||.:.:..:.||:.:.:|...|:
Mouse  1133 DQWYLIFFNLLFSSLPQLVTGVLDKDVPADMLLREPQLYKSGQNMEEYRPRAFWLNMVDAAFQSL 1197

  Fly  1115 FLFWLP-LAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVL 1178
            ..|::| ||.|..:|        |....|..|....:.|..|..|:.|.:||||..||...|..|
Mouse  1198 VCFFIPYLAYYDSDV--------DVFTWGTPVTAIALFTFLLHLGIETKTWTWLNWLACGFSTFL 1254

  Fly  1179 WFGFLLIY-----------SHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKL 1232
            :|...|||           :..|.|           ..||..|:||...::.||..||..:..|.
Mouse  1255 FFSVALIYNTSCATCYPPSNPYWTM-----------QTLLGDPLFYLTCLIAPIAALLPRLFFKA 1308

  Fly  1233 VHNTVFKTLTEAVRETEIRRSDISEVMNEPRSSDSGFGYALGKLIRSSHILISHDHHPVSESSRT 1297
            :..::|.|      :.::.|....:.:|  :.||....:|.|:         ...|.....|.|.
Mouse  1309 LQGSLFPT------QLQLGRQLAKKPLN--KFSDPKETFAQGQ---------PPGHSETELSERK 1356

  Fly  1298 SNLRVENLEMEADTEQQQQSRQ 1319
            :....|.|..:..::..|.::|
Mouse  1357 TMGPFETLPRDCASQASQFTQQ 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	23/66 (35%)
		ATPase-Plipid	229..1247	CDD:273734	416/1279 (33%)
		E1-E2_ATPase	286..>371	CDD:278548	40/86 (47%)
		Cation_ATPase	645..741	CDD:289987	40/209 (19%)
		HAD_like	<942..1001	CDD:304363	35/58 (60%)
		PhoLip_ATPase_C	988..1240	CDD:292829	84/263 (32%)
Atp10a	NP_033858.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		6/29 (21%)
		P-type_ATPase_APLT_Dnf-like	65..1203	CDD:319770	378/1138 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..705		0/24 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1334..1354		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1407..1436
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1481..1508
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830