Protein Alignment ATP8A and Atp10a

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_033858.2
• Gene: Atp10a / 11982
• MGIID: 1330809
• Length: 1508
• Species: Mus musculus
• Alignment Length: 1452
• Identity: 447/1452 - (30%)
• Similarity: 675/1452 - (46%)
• Gaps: 349/1452 - (24%)

  Fly   138 PASVSTSVGGTLSSRRRSSNRKDSKGSILSRQSGKSRV---SLLAQRGLRMTASFLRRKRTEYED 199
            ||:..::..|....|||             |..|::|.   :||...|
Mouse     6 PAAEESASSGWRRPRRR-------------RWEGRTRTVRSNLLPPLG----------------- 40

  Fly   200 DEDFTSSAGYDADDGERRII-----NLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNC 259
                |..:...|..|||.::     :|        .:||:.|.||:.:||||..|||||.|.:|.
Mouse    41 ----TEDSTIGAPKGERLLMRGCIQHL--------ADNRLKTTKYTLLSFLPKNLFEQFHRLANV 93

  Fly   260 FFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRS--IERLDSGS 322
            :|:.||:|..:|.|:.......|.|::|||:|:|||::.||..|||:|:||||..  :...:...
Mouse    94 YFVFIALLNFVPAVNAFQPGLALAPVLFILAVTAIKDLWEDYSRHRSDHEINHLGCLVFSREEKK 158

  Fly   323 WCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELL 387
            :....|.|:.|||.:::..|...|||::|||||:|..:|.|||||||||||||.||.:...:||:
Mouse   159 YVNRYWKEIRVGDFVRLCCNEIIPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSELV 223

  Fly   388 ETKDLQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQ 452
            ...:.......||||.||..|..|.|.:..:....|.|..:.:|.||..:|||..|.|||:|:|.
Mouse   224 SEFNPLTFTSVIECEKPNNDLSRFRGYIMHSNGEKAGLHKENLLLRGCTIRNTEAVAGIVIYAGH 288

  Fly   453 ETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKT 517
            |||.:.|::....|||.:::..|..:|...::|:.:.:.|.:.:..|.|.:.|......:.:...
Mouse   289 ETKALLNNSGPRYKRSQLERQMNCDVLWCVLLLVCISLFSAVGHGLWVRRYQEKKALFDVPESDG 353

  Fly   518 KSLG------YNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNL 576
            .||.      |:..|..|:...||||||.|::|:|:..|..|||.|||:|.||:::....|..|:
Mouse   354 SSLSPATAAVYSFFTMIIVLQVLIPISLYVSIEIVKVCQVYFINQDIELYDEETDSQLQCRALNI 418

  Fly   577 NEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYT-----------AERTPEESQLV------- 623
            .|:||.:||||||||||||:|.|.|::|:::|..|:           .|...||.::|
Mouse   419 TEDLGQIKYIFSDKTGTLTENKMVFRRCTVSGIEYSHDANAQRLARYQEADSEEEEVVSKVGTIS 483

  Fly   624 --------QNILGRHETSAV--------------------------------------------- 635
                    |:|...|:|.::
Mouse   484 HRGSTGSHQSIWMTHKTQSIKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPDPKLLEKVSEC 548

  Fly   636 -----------------------IEEFLELLSVCHTVI--------------------------- 650
                                   :.:|...|::|:||:
Mouse   549 DRFLAIARHQEHPLAHLSPELSDVFDFFIALTICNTVVVTSPDQPRQKVRVRFELKSPVKTIEDF 613

  Fly   651 -----PER--------------------------------------------------------- 653
                 |.|
Mouse   614 LRRFTPSRLASGCSSIGNLSTSKSSHKSGSAFLPSLSQDSMLLGLEEKLGQTAPSIASNGYASQA 678

  Fly   654 ----------------------KENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKY--VEINA 694
                                  ::.|.:.|.|.||||.|||..|:.:......|....  ||:..
Mouse   679 GQEESWASECTTDQKCPGEQREQQEGELRYEAESPDEAALVYAARAYNCALVDRLHDQVSVELPH 743

  Fly   695 LGVRKRYEVLNVLEFTSSRKRMSLIVRTP-ENKIKLFCKGADTVIYERLAP---------QGQAF 749
            || |..:|:|:.|.|.|.|||||:::|.| .::|.::.||||:|:.:.|.|         ..:..
Mouse   744 LG-RLTFELLHTLGFDSIRKRMSVVIRHPLTDEINVYTKGADSVVMDLLLPCSSDDARGRHQKKI 807

  Fly   750 REQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRL 814
            |.:|..:|..:|.:||||||:|...:..:.|..|.|:..:|..::::||..|..:|..:|.||.|
Mouse   808 RSKTQNYLNLYAVEGLRTLCIAKRVLSKEEYACWLQSHIEAEASVESREELLFQSAVRLETNLHL 872

  Fly   815 LGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDA 879
            ||||.||||||:|||||||.|..||:.|||||||||||||||.|:|:|:.|..::|.||.:|.:|
Mouse   873 LGATGIEDRLQEGVPETIAKLRQAGLQIWVLTGDKQETAINIAYACKLLDHGEEVITLNADSQEA 937

  Fly   880 TREVIHRHYGEFKS-----------------------SSAKDA--NVALVIDGTTLKYALSCDLR 919
            ...::.:.....:|                       |::.||  :.:|||||.:|.|||...|.
Mouse   938 CAALLDQCLSYVQSRNPRSTLQNSESNLSVGFSFNPVSTSTDASPSPSLVIDGRSLAYALEKSLE 1002

  Fly   920 NDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEG 984
            :.|..|...||.|:|||.:|:||:.||::|.....|:|||||||||||:|||.|:||:||||.||
Mouse  1003 DKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEG 1067

  Fly   985 LQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILF 1049
            :||..|||:::.:||||:|||:|||.|.|:|::.::||.||||.....:..||..|.|:|...:.
Mouse  1068 MQAVMASDFAVPRFRYLERLLIVHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFYCGFSASAMI 1132

  Fly  1050 ERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSV 1114
            ::|.:..:|:||:::|....|:.:|...|:.::|.|.|||:.||.:.:..:.||:.:.:|...|:
Mouse  1133 DQWYLIFFNLLFSSLPQLVTGVLDKDVPADMLLREPQLYKSGQNMEEYRPRAFWLNMVDAAFQSL 1197

  Fly  1115 FLFWLP-LAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVL 1178
            ..|::| ||.|..:|        |....|..|....:.|..|..|:.|.:||||..||...|..|
Mouse  1198 VCFFIPYLAYYDSDV--------DVFTWGTPVTAIALFTFLLHLGIETKTWTWLNWLACGFSTFL 1254

  Fly  1179 WFGFLLIY-----------SHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKL 1232
            :|...|||           :..|.|           ..||..|:||...::.||..||..:..|.
Mouse  1255 FFSVALIYNTSCATCYPPSNPYWTM-----------QTLLGDPLFYLTCLIAPIAALLPRLFFKA 1308

  Fly  1233 VHNTVFKTLTEAVRETEIRRSDISEVMNEPRSSDSGFGYALGKLIRSSHILISHDHHPVSESSRT 1297
            :..::|.|      :.::.|....:.:|  :.||....:|.|:         ...|.....|.|.
Mouse  1309 LQGSLFPT------QLQLGRQLAKKPLN--KFSDPKETFAQGQ---------PPGHSETELSERK 1356

  Fly  1298 SNLRVENLEMEADTEQQQQSRQ 1319
            :....|.|..:..::..|.::|
Mouse  1357 TMGPFETLPRDCASQASQFTQQ 1378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	378/1138 (33%)
Atp10a	NP_033858.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		6/29 (21%)
		P-type_ATPase_APLT_Dnf-like	65..1203	CDD:319770	378/1138 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	680..705		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1334..1354		4/28 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1407..1436
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1481..1508