Protein Alignment ATP8A and Atp9a

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_056546.2
• Gene: Atp9a / 11981
• MGIID: 1330826
• Length: 1047
• Species: Mus musculus
• Alignment Length: 1062
• Identity: 313/1062 - (29%)
• Similarity: 522/1062 - (49%)
• Gaps: 128/1062 - (12%)

  Fly   217 RIINLNGPQ--PTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRY 279
            |.:.|..|:  ..:|..|.|...||:|.:|||..||.|||.:.|.:|||:|..|.:||:.....|
Mouse    39 RTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFSQFRYFFNFYFLLLACSQFVPEMRLGALY 103

  Fly   280 TTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTF 344
            |..|||.|:|:|:.|:|.:|:|:.:..|.|:|.:...||.|.....|:.|.:.|||:|.|..|..
Mouse   104 TYWVPLGFVLAVTIIREAVEEIRCYVRDKEMNSQVYSRLTSRGTVKVKSSNIQVGDLILVEKNQR 168

  Fly   345 FPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLY 409
            .|||:|.|.:||....||:.|..|||||:.|:|..:..|..|....||.::...:..|.||..::
Mouse   169 VPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQIRSYVYAEEPNIDIH 233

  Fly   410 EFNGVL-RETGKPPAALGNDQVLQRGAILRNTAW---------VFGIVVYSGQETKLMKNSTSAP 464
            .|.|.. ||...||        :.....:.||.|         |.|:|:|:|:|.:.:.|::...
Mouse   234 NFLGTFTREDSDPP--------ISESLSIENTLWAGTVIASGTVVGVVLYTGRELRSVMNTSDPR 290

  Fly   465 LKRSTVDKLTN--TQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGYNLLTF 527
            .|....|...|  |:||...::::||.:::        .:|....|||            .::.|
Mouse   291 SKIGLFDLEVNCLTKILFGALVVVSLVMVA--------LQHFAGRWYL------------QIIRF 335

  Fly   528 FILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTP-AMARTSNLNEELGMVKYIFSDKT 591
            .:|::|:|||||:|.|::.:.:.:..|..|       |..| .:.|:|.:.|:||.:.|:.:|||
Mouse   336 LLLFSNIIPISLRVNLDMGKIVYSWVIRRD-------SKIPGTVVRSSTIPEQLGRISYLLTDKT 393

  Fly   592 GTLTQNVMEFKKCSIAGYVYTAERTPEESQLVQNILG------------------RHETSAVIEE 638
            ||||||.|.||:..:....|..:...|....:.:|..                  |...|:.:.|
Mouse   394 GTLTQNEMVFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTVTTKVRRTMSSRVHE 458

  Fly   639 FLELLSVCHTVIPERKENG--------------NMIYHAASPDERALVEGAQKFGYIFDTRTPKY 689
            .::.:::||.|.|..:.||              ..:|.|:||||.|||:..:..|.....|....
Mouse   459 AVKAIALCHNVTPVYESNGVTDQAEAEKQFEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSS 523

  Fly   690 VEINALGVR-KRYEVLNVLEFTSSRKRMSLIVRTPE-NKIKLFCKGADTVIYERLAPQGQAFREQ 752
            :::...|.: ....:|.|..||...|||.:|||... .:|..:.||||.|:         |...|
Mouse   524 MQLRTPGDQVLNLTILQVFPFTYESKRMGIIVRDESTGEITFYMKGADVVM---------AGIVQ 579

  Fly   753 TLRHLEE----FASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLR 813
            ....|||    .|.:|||.|.:|...:..:.||::...:.:|.:::.:|..|:......:|..:.
Mouse   580 YNDWLEEECGNMAREGLRVLVVAKKSLTEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEME 644

  Fly   814 LLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLD 878
            ||..|.:||:||..|..|:.:|.:|||.:|:|||||.|||.....:..|::.:.||.:..   |.
Mouse   645 LLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFR---LV 706

  Fly   879 ATREVIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKA 943
            ..|...|.....|:    :..:.||||.|.:|:..|.. ...:|.:|...|..|:|||.:|.|||
Mouse   707 TNRGEAHLELNAFR----RKHDCALVISGDSLEVCLKY-YEYEFMELACQCPAVVCCRCAPTQKA 766

  Fly   944 EVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVH 1008
            ::|.::.:.|..:|.|:|||.|||:|||:::.|:|:.|.||.||:.|:|:||.||::|.|||:||
Mouse   767 QIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVH 831

  Fly  1009 GAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFE 1073
            |..:|.|.:.|..:..::::|:..::..|:....::...|::.:.|..|:.::|..|.|:: :.:
Mouse   832 GRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSL-VLD 895

  Fly  1074 KFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDY 1138
            |...:|..:.||.|||.....:..:.|.|.||:..::.....:.:..|..:          .|::
Mouse   896 KDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGALLLF----------ESEF 950

  Fly  1139 LLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMD 1203
            :.:..:.:|.:|:|..|...|...:|.||..:|...|:..:...|:          |...|  :|
Mouse   951 VHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLV----------FLHEF--ID 1003

  Fly  1204 IQLLSTPVFYFCLMLVPITTLL 1225
            :..::|..|.:.:.::.:.:.|
Mouse  1004 VYFIATLSFLWKVSVITLVSCL 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	290/939 (31%)
Atp9a	NP_056546.2	P-type_ATPase_APLT_Neo1-like	55..967	CDD:319841	295/974 (30%)
		Cation_ATPase	464..571	CDD:463817	31/106 (29%)