Protein Alignment ATP8A and Atp8a1

DIOPT Version :9

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_017176112.1
• Gene: Atp8a1 / 11980
• MGIID: 1330848
• Length: 1177
• Species: Mus musculus
• Alignment Length: 1147
• Identity: 639/1147 - (55%)
• Similarity: 822/1147 - (71%)
• Gaps: 42/1147 - (3%)

  Fly   181 RGLRMTASFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFL 245
            || |:|.:...||...||..:|.:..... ||..|.|.|.:|.||.||:.||.::||||:.|:||
Mouse    16 RG-RLTHNQGARKPPGYEKTDDVSEKTSL-ADQEEVRTIFINQPQLTKFCNNHVSTAKYNVITFL 78

  Fly   246 PAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEI 310
            |.||:.||||.:|.|||.||:|||||:|||||||||||||:|||:|:||||||||||||:|||.:
Mouse    79 PRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAV 143

  Fly   311 NHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLK 375
            |.:..:.|.:|:|..|.|.::.||:|:||......||||:.||||||||||:|||:|||||||||
Mouse   144 NKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLLSLSSSEPQAMCYIETSNLDGETNLK 208

  Fly   376 IRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNT 440
            |||.||||:::.:...|.|:.||||||.||||||:|.|.:|..|.....||.||:|.|||.||||
Mouse   209 IRQGLPATSDIKDIDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNT 273

  Fly   441 AWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSE 505
            .||.|||||:|.:||||:||||.|||.|.|:::||.|||:||.|||::.::..:.:..|.|.||.
Mouse   274 QWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSG 338

  Fly   506 TDWYLGLTDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAM 570
            .||||.|......:.|.|.|||.||:||||||||.||||:|:|.||.|||:|::|::|.::|.||
Mouse   339 KDWYLHLHYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAM 403

  Fly   571 ARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY---------------------TAE 614
            |||||||||||.|||||||||||||.|||:||||:|||..|                     ..|
Mouse   404 ARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQSSQFGDE 468

  Fly   615 RTPEESQLVQNILGRHETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFG 679
            :|..:..|:.|:...|.|:.:|.|||.:::||||.:||| |...:||.||||||.|||..|::..
Mouse   469 KTFNDPSLLDNLQNNHPTAPIICEFLTMMAVCHTAVPER-EGDKIIYQAASPDEGALVRAAKQLN 532

  Fly   680 YIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAP 744
            ::|..|||..|.|::||..:|||:||||||||:|||||::||||..|::|:|||||||||||||
Mouse   533 FVFTGRTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVVVRTPSGKLRLYCKGADTVIYERLA- 596

  Fly   745 QGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIE 809
            :...::|.||:|||:||::||||||.|||:|....::||...:.:||.::|||..|||::..|||
Mouse   597 ETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFEEWRAVYHRASTSVQNRLLKLEESYELIE 661

  Fly   810 NNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNE 874
            .||:|||||||||:|||.|||||.:|:.|.|.||:|||||||||||||:||||:..:|.:|::||
Mouse   662 KNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCRLLKRNMGMIVINE 726

  Fly   875 ESLDATREVIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSP 939
            .|||.|||.:.||......:..|:.:.||:|||.||||||:..:|..|.||.:.|:.||||||||
Mouse   727 GSLDGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSP 791

  Fly   940 MQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRL 1004
            :||:||||||.:....:|||||||||||:|||.|:||:||||.||||||.:||||||||:||:.|
Mouse   792 LQKSEVVEMVKKQVKVITLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNL 856

  Fly  1005 LLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAM 1069
            |:|||||||.|:||.|||.||||:.||:||:|||..:|:|||||||||.||||||:||||||..:
Mouse   857 LMVHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTL 921

  Fly  1070 GLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGK 1134
            |:||:.|..|.|::||.||||||||..||.||||:...|.|.|||.|||.||.|.....::.:||
Mouse   922 GIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTVFGNGK 986

  Fly  1135 TSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNF 1199
            ||||||:||.|||:|::||||||||.|:.|||.:|:||||||.||..|..|||.:||....|.:.
Mouse   987 TSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAVPMAPDM 1051

  Fly  1200 RGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEPRS 1264
            .|....|.|:.||:..|:.:|:.:||:||:.|::..|.||||.:.|:|.|.:..|...|:
Mouse  1052 SGEAAMLFSSGVFWVGLLSIPVASLLLDVLYKVIKRTAFKTLVDEVQELEAKSQDPGAVV----- 1111

  Fly  1265 SDSGFGYALGKLIRSSHILISHDHHPVSESSRTSNLRVENLE 1306
                    |||.:.....|:.:    |.:.:..:..|.|:|:
Mouse  1112 --------LGKSLTERAQLLKN----VFKKNHVNLYRSESLQ 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	39/61 (64%)
		ATPase-Plipid	229..1247	CDD:273734	608/1038 (59%)
		E1-E2_ATPase	286..>371	CDD:278548	50/84 (60%)
		Cation_ATPase	645..741	CDD:289987	59/95 (62%)
		HAD_like	<942..1001	CDD:304363	42/58 (72%)
		PhoLip_ATPase_C	988..1240	CDD:292829	148/251 (59%)
Atp8a1	XP_017176112.1	ATPase-Plipid	62..1099	CDD:273734	608/1038 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	328	1.000	Domainoid score	I1167
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48402
Inparanoid	1	1.050	1259	1.000	Inparanoid score	I174
Isobase	1	0.950	-	0	Normalized mean entropy	S688
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm42710
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790