DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ATP8A and ATP8A1

DIOPT Version :9

Sequence 1:NP_001137651.1 Gene:ATP8A / 36488 FlyBaseID:FBgn0259221 Length:1350 Species:Drosophila melanogaster
Sequence 2:XP_011511917.1 Gene:ATP8A1 / 10396 HGNCID:13531 Length:1171 Species:Homo sapiens


Alignment Length:1152 Identity:637/1152 - (55%)
Similarity:822/1152 - (71%) Gaps:48/1152 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   183 LRMTASFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPA 247
            :|.|.|.:|.:...||..:|.:..... ||..|.|.|.:|.||.||:.||.::||||:.|:|||.
Human     4 MRRTVSEIRSRAEGYEKTDDVSEKTSL-ADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPR 67

  Fly   248 FLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINH 312
            ||:.||||.:|.|||.||:|||||:|||||||||||||:|||:|:||||||||||||:|||.:|.
Human    68 FLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNK 132

  Fly   313 RSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIR 377
            :..:.|.:|:|..|.|.::.||||:.:....:.|||.:|||||||||||:|||:|||||||||||
Human   133 KQTQVLRNGAWEIVHWEKVNVGDIVIIKGKEYIPADTVLLSSSEPQAMCYIETSNLDGETNLKIR 197

  Fly   378 QALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAW 442
            |.||||:::.:...|.|:.||||||.||||||:|.|.:|..|.....||.||:|.|||.||||.|
Human   198 QGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQW 262

  Fly   443 VFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETD 507
            |.|||||:|.:||||:||||.|||.|.|:::||.|||:||.|||::.::..:.:..|.|.||..|
Human   263 VHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKD 327

  Fly   508 WYLGLTDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMAR 572
            |||.|......:.|.|.|||.||:||||||||.||||:|:|.||.|||:|::|::|.::|.||||
Human   328 WYLNLNYGGASNFGLNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMAR 392

  Fly   573 TSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY---------------------TAERT 616
            |||||||||.|||||||||||||.|||:||||:|||..|                     ..|:|
Human   393 TSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQNSQFGDEKT 457

  Fly   617 PEESQLVQNILGRHETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYI 681
            ..:|.|::|:...|.|:.:|.|||.:::||||.:||| |...:||.||||||.|||..|::..::
Human   458 FSDSSLLENLQNNHPTAPIICEFLTMMAVCHTAVPER-EGDKIIYQAASPDEGALVRAAKQLNFV 521

  Fly   682 FDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQG 746
            |..|||..|.|::||..:|||:||||||||:|||||:|||||..|::|:|||||||||:||| :.
Human   522 FTGRTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLA-ET 585

  Fly   747 QAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENN 811
            ..::|.||:|||:||::||||||.|||:|....:|||...:.:||.::|||..|||::..|||.|
Human   586 SKYKEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKN 650

  Fly   812 LRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEES 876
            |:|||||||||:|||.|||||.:|:.|.|.||:|||||||||||||:||:|:..:|.:|::||.|
Human   651 LQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGS 715

  Fly   877 LD-------ATREVIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVIC 934
            ||       .|||.:.||......:..|:.:.||:|||.||||||:..:|..|.||.:.|:.|||
Human   716 LDVEDRAVEGTRETLSRHCTTLGDALRKENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVIC 780

  Fly   935 CRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFR 999
            |||||:||:||||||.:....||||||||||||:|||.|:||:||||.||||||.:||||||||:
Human   781 CRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFK 845

  Fly  1000 YLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAM 1064
            ||:.||::||||||.|:||.|||.||||:.||:||:|||..:|:|||||||||.||||||:||||
Human   846 YLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAM 910

  Fly  1065 PPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVI 1129
            ||..:|:||:.|..|.|::||.||||||||..||.||||:...|.|.|||.|||.||.|......
Human   911 PPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTA 975

  Fly  1130 WSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFK 1194
            :.:||||||||:||.|||:|::||||||||.|:.|||.:|:||||||.||..|..|||.:||...
Human   976 FGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVFFGIYSSLWPAIP 1040

  Fly  1195 FASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVM 1259
            .|.:..|....|.|:.||:..|:.:|:.:||:||:.|::..|.||||.:.|:|.|.:..|...|:
Human  1041 MAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIKRTAFKTLVDEVQELEAKSQDPGAVV 1105

  Fly  1260 NEPRSSDSGFGYALGKLIRSSHILISHDHHPVSESSRTSNLRVENLE 1306
                         |||.:.....|:.:    |.:.:..:..|.|:|:
Human  1106 -------------LGKSLTERAQLLKN----VFKKNHVNLYRSESLQ 1135

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8ANP_001137651.1 PhoLip_ATPase_N 218..280 CDD:292826 39/61 (64%)
ATPase-Plipid 229..1247 CDD:273734 608/1045 (58%)
E1-E2_ATPase 286..>371 CDD:278548 49/84 (58%)
Cation_ATPase 645..741 CDD:289987 60/95 (63%)
HAD_like <942..1001 CDD:304363 43/58 (74%)
PhoLip_ATPase_C 988..1240 CDD:292829 147/251 (59%)
ATP8A1XP_011511917.1 PhoLip_ATPase_N 38..100 CDD:292826 39/61 (64%)
ATPase-Plipid 49..1093 CDD:273734 608/1045 (58%)
E1-E2_ATPase 106..>191 CDD:278548 49/84 (58%)
Cation_ATPase 486..581 CDD:289987 60/95 (63%)
HAD_like <803..853 CDD:304363 39/49 (80%)
PhoLip_ATPase_C 834..1086 CDD:292829 147/251 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 328 1.000 Domainoid score I1166
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H48402
Inparanoid 1 1.050 1264 1.000 Inparanoid score I172
Isobase 1 0.950 - 0 Normalized mean entropy S688
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 1 1.000 - - otm40635
orthoMCL 1 0.900 - - OOG6_100089
Panther 1 1.100 - - O PTHR24092
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1985
SonicParanoid 1 1.000 - - X168
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

Return to query results.
Submit another query.