DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and atp9a

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	XP_005174184.3	Gene:	atp9a / 101886226	-ID:	-	Length:	1046	Species:	Danio rerio

Alignment Length:	1049	Identity:	306/1049 - (29%)
Similarity:	511/1049 - (48%)	Gaps:	141/1049 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 DGERRIINLNGPQ--PTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSP 275
            |...|.:.|..|:  ..:|..|.|...||:|.:|||..||.||:.:.|.:|||:|..|.:.|:..
Zfish    35 DFRPRTVWLGHPEKREQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVNELRL 99

  Fly   276 TGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVG 340
            ...||..|||.|:|.::.::|.:|:::....|.|:|.:...:|.:.....|:.|.:.|||:|.|.
Zfish   100 GALYTYWVPLGFVLIITIVREAVEEVRCFLRDKEVNSQIYSKLSTRGTVKVKSSGIQVGDLIIVE 164

  Fly   341 INTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPN 405
            .|...|||:|.|.:||....||:.|..|||||:.|:|..:..|..|....||.::...:..|.||
Zfish   165 KNQRVPADMIFLRTSERNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQIRSFVYAEEPN 229

  Fly   406 RHLYEFNGVL-RETGKPPAALGNDQVLQRGAILRNTAW---------VFGIVVYSGQETKLMKNS 460
            ..::.|.|.. ||.|.||        :.....:.||.|         |.|:|:|:|:|.:.:.|:
Zfish   230 IDIHNFIGTFTREDGDPP--------VNESLSIENTLWASTVIASGTVVGVVIYTGKELRSVMNT 286

  Fly   461 TSAPLKRSTVDKLTN--TQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGYN 523
            ::...|....|...|  |:||...::::||.:::        .:|....|||            .
Zfish   287 SNPRHKIGLFDLEVNCLTKILFGALVVVSLVMVA--------LQHFAGRWYL------------Q 331

  Fly   524 LLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTP-AMARTSNLNEELGMVKYIF 587
            :..|.:|::|::||||:|.|::.:.:.:..|..|       |..| .:.|.|.:.|:||.:.|:.
Zfish   332 IFRFLLLFSNIVPISLRVNLDMGKMVFSWMIKKD-------SKIPGTVVRASTIPEQLGRISYLL 389

  Fly   588 SDKTGTLTQNVMEFKKC-------------SIAGYVYTAERTPEESQLVQNILG----RHETSAV 635
            :|||||||||.|.|::.             .:..:|::|...|.:........|    |...|:.
Zfish   390 TDKTGTLTQNEMVFRRLHLGTVAYGMDSMDEVQSHVFSAYTQPPQDLQASRAPGATKVRKTISSR 454

  Fly   636 IEEFLELLSVCHTVIPERKENG--------------NMIYHAASPDERALVEGAQKFGYI----- 681
            :.|.::.:::.|.|.|..:.||              ..:|.|:||||.:||:..:..|..
Zfish   455 VHEAVKAIALVHNVTPVYEANGVTDQAEAEQHYEDTCRVYQASSPDEVSLVQWTESVGLTLVGRD 519

  Fly   682 ---FDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPE-NKIKLFCKGADTVIYERL 742
               ...|||....:|       :.:|.:..||...|||.:|||... .:|..:.||||.|:
Zfish   520 QSSMQLRTPSGQILN-------FTILQIFPFTYESKRMGIIVRDESTGEITFYMKGADVVM---- 573

  Fly   743 APQGQAFREQTLRHLEE----FASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLED 803
                 |...|....|||    .|.:|||.|.:|...:..:.||::...:.:|.:::.:|..|:..
Zfish   574 -----AGIVQYNDWLEEECGNMAREGLRVLVVAKKSLTEEQYQDFEARYVQAKLSVHDRSLKVAT 633

  Fly   804 AANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMD 868
            ....:|..:.||..|.:||:||..|..|:..|.:|||.:|:|||||.|||.....:..|::.:.|
Zfish   634 VIESLEMEMELLCLTGVEDQLQADVRPTLEILRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQD 698

  Fly   869 IIILNEESLDATREVIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVI 933
            |.:....:   ||...|.....|:    :..:.||||.|.:|:..|.. ...:|.:|...|..|:
Zfish   699 IHVFRPVT---TRSEAHLELNAFR----RKHDCALVISGDSLEVCLKY-YEYEFMELACQCPAVV 755

  Fly   934 CCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQF 998
            |||.:|.|||::|.::.:.|..:|.|:|||.|||:|||:|:.|:|:.|.||.||:.|:|:||.||
Zfish   756 CCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQEADCGVGVEGKEGKQASLAADFSITQF 820

  Fly   999 RYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTA 1063
            ::|.|||:|||..:|.|.:.|..:..::::|:..::..|:....::...|::.:.|..|:.::|.
Zfish   821 KHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTM 885

  Fly  1064 MPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEV 1128
            .|.|:: :.:|...:|..:.||.|||.....:..:.|.|.||:..::.....:.:..|..:
Zfish   886 FPVFSL-VLDKDVKSEVAMLYPELYKDLLKGRPLSFKTFLIWVLISIYQGSIIMYGALLLF---- 945

  Fly  1129 IWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTW------LTHLAIW-GSIVLWFGFLLIY 1186
                  .|:::.:..:.:|.:|:|..|...|...:|.|      |..||.: .|:|....|:.:|
Zfish   946 ------ESEFVHIVAISFTSLILTELLMVALTIQTWHWLMIVAELLSLACYIASLVFLHEFIDVY 1004

  Fly  1187 -----SHVW 1190
                 |.:|
Zfish  1005 FIATLSFIW 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	22/63 (35%)
		ATPase-Plipid	229..1247	CDD:273734	302/1031 (29%)
		E1-E2_ATPase	286..>371	CDD:278548	28/84 (33%)
		Cation_ATPase	645..741	CDD:289987	33/118 (28%)
		HAD_like	<942..1001	CDD:304363	29/58 (50%)
		PhoLip_ATPase_C	988..1240	CDD:292829	53/215 (25%)
atp9a	XP_005174184.3	P-type_ATPase_APLT_Neo1-like	55..966	CDD:319841	288/980 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930